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[An association analysis of apolipoprotein E genotypes with Alzheimer's disease in Chinese population].

Abstract

OBJECTIVE

To analyse the association of apolipoprotein E genotypes with Alzheimer's disease in Chinese population.

METHODS

Using PCR and restriction enzyme digestion, we have analyzed ApoE allele frequency of Alzheimer's disease (AD) patients and healthy controls.

RESULTS

Among the 56 cases of AD, the frequency of ApoE epsilon 2, ApoE epsilon 3, ApoE epsilon 4 are 3 (2.7%), 84 (75.0%), 25 (22.3%) respectively, while in the 67 controls they are 9 (6.7%), 115 (85.8%), 10 (7.5%) respectively. The frequencies of the two groups have significant difference (P < 0.01) and the frequency of ApoE epsilon 4 allele is higher in AD than that in the health controls and the statistical treatment suggest that there is significant difference (chi 2 = 10.99, P < 0.01, OR = 3.59, 95% CI = 1.54-8.41). The frequency of the ApoE epsilon 3 is lower in AD than that in the health controls and the difference is also statistically significant(P < 0.05).

CONCLUSIONS

Our results are consistent with previous work in that proving the ApoE epsilon 4 allele is one of the risk factors of AD. The results also provide a support for the protection effect of ApoE epsilon 3 allele in developing AD.

Authors+Show Affiliations

National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, CAMS, PUMC, Beijing 100005, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

12905860

Citation

Wu, Y N., et al. "[An Association Analysis of Apolipoprotein E Genotypes With Alzheimer's Disease in Chinese Population]." Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae, vol. 23, no. 5, 2001, pp. 450-4.
Wu YN, Zhang JW, Zhang ZX, et al. [An association analysis of apolipoprotein E genotypes with Alzheimer's disease in Chinese population]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2001;23(5):450-4.
Wu, Y. N., Zhang, J. W., Zhang, Z. X., Qu, Q. M., & Chen, D. (2001). [An association analysis of apolipoprotein E genotypes with Alzheimer's disease in Chinese population]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae, 23(5), pp. 450-4.
Wu YN, et al. [An Association Analysis of Apolipoprotein E Genotypes With Alzheimer's Disease in Chinese Population]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2001;23(5):450-4. PubMed PMID: 12905860.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [An association analysis of apolipoprotein E genotypes with Alzheimer's disease in Chinese population]. AU - Wu,Y N, AU - Zhang,J W, AU - Zhang,Z X, AU - Qu,Q M, AU - Chen,D, PY - 2003/8/9/pubmed PY - 2004/3/17/medline PY - 2003/8/9/entrez SP - 450 EP - 4 JF - Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae JO - Zhongguo Yi Xue Ke Xue Yuan Xue Bao VL - 23 IS - 5 N2 - OBJECTIVE: To analyse the association of apolipoprotein E genotypes with Alzheimer's disease in Chinese population. METHODS: Using PCR and restriction enzyme digestion, we have analyzed ApoE allele frequency of Alzheimer's disease (AD) patients and healthy controls. RESULTS: Among the 56 cases of AD, the frequency of ApoE epsilon 2, ApoE epsilon 3, ApoE epsilon 4 are 3 (2.7%), 84 (75.0%), 25 (22.3%) respectively, while in the 67 controls they are 9 (6.7%), 115 (85.8%), 10 (7.5%) respectively. The frequencies of the two groups have significant difference (P < 0.01) and the frequency of ApoE epsilon 4 allele is higher in AD than that in the health controls and the statistical treatment suggest that there is significant difference (chi 2 = 10.99, P < 0.01, OR = 3.59, 95% CI = 1.54-8.41). The frequency of the ApoE epsilon 3 is lower in AD than that in the health controls and the difference is also statistically significant(P < 0.05). CONCLUSIONS: Our results are consistent with previous work in that proving the ApoE epsilon 4 allele is one of the risk factors of AD. The results also provide a support for the protection effect of ApoE epsilon 3 allele in developing AD. SN - 1000-503X UR - https://www.unboundmedicine.com/medline/citation/12905860/[An_association_analysis_of_apolipoprotein_E_genotypes_with_Alzheimer's_disease_in_Chinese_population]_ L2 - https://medlineplus.gov/alzheimersdisease.html DB - PRIME DP - Unbound Medicine ER -