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[Comparative effects of carvedilol and metoprolol in preventing from left ventricular remodeling after acute myocardial infarction in rats].
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2001 Oct; 23(5):476-80.ZY

Abstract

OBJECTIVE

To compare the effects of carvedilol and metoprolol in preventing from left ventricular remodeling (LVRM) after acute myocardial infarction (AMI) in rats.

METHODS

Twenty-four hours after ligating left coronary artery, 105 surviving female SD rats were randomly assigned to AMI control, carvedilol 1 mg/(kg.d) and metoprolol 2 mg/(kg.d) groups. Sham-operated rats (n = 16) were selected randomly as non-infarction control. After four weeks of drugs therapy, hemodynamic studies and pathologic analysis were performed. Exclusive of MI size < 35% or > 55%, complete experimental variables were obtained in 46 rats, which were comprised of AMI (n = 11), carvedilol (n = 12), metoprolol (n = 11), and Sham-operated (n = 12) groups.

RESULTS

Compared with sham-operated group, left ventricular (LV) end diastolic pressure (LVEDP), volume (LVV) and weight (LVW), were all significantly increased (P < 0.05-0.001), while maximal rate of rise and fall (+/- dp/dt) of LV pressure as well as their corrected values (+/- dp/dt/LVSP) were all significantly decreased (P < 0.01-0.001) in AMI group. In comparison with AMI group, the LVEDP and LVV were all significantly decreased (all P < 0.001), while +/- dp/dt and +/- dp/dt/LVSP were significantly increased (P < 0.05-0.001) in both carvedilol and metoprolol group, with LVW and RVW only decreased in carvedilol group (P < 0.05-0.01).

CONCLUSIONS

1. Carvedilol can effectively attenuate LVRM, and improve hemodynamics and LV function after AMI in rats, 2. Metoprolol has equivalent beneficial effects as carvedilol on hemodynamics, LV dilatation and function, but not LV hypertrophy.

Authors+Show Affiliations

Department of Coronary Heart Disease, Cardiovascular Institute, FuWai Hospital, CAMS, PUMC, Beijing 100037, China. tyd211@sina.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

chi

PubMed ID

12905866

Citation

Tang, Y D., et al. "[Comparative Effects of Carvedilol and Metoprolol in Preventing From Left Ventricular Remodeling After Acute Myocardial Infarction in Rats]." Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae, vol. 23, no. 5, 2001, pp. 476-80.
Tang YD, Yang YJ, Zhang P, et al. [Comparative effects of carvedilol and metoprolol in preventing from left ventricular remodeling after acute myocardial infarction in rats]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2001;23(5):476-80.
Tang, Y. D., Yang, Y. J., Zhang, P., Ruan, Y. M., Lu, S. Q., Sun, R. C., Wang, P. H., Gao, R. L., Chen, J. L., & Chen, Z. J. (2001). [Comparative effects of carvedilol and metoprolol in preventing from left ventricular remodeling after acute myocardial infarction in rats]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae, 23(5), 476-80.
Tang YD, et al. [Comparative Effects of Carvedilol and Metoprolol in Preventing From Left Ventricular Remodeling After Acute Myocardial Infarction in Rats]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2001;23(5):476-80. PubMed PMID: 12905866.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Comparative effects of carvedilol and metoprolol in preventing from left ventricular remodeling after acute myocardial infarction in rats]. AU - Tang,Y D, AU - Yang,Y J, AU - Zhang,P, AU - Ruan,Y M, AU - Lu,S Q, AU - Sun,R C, AU - Wang,P H, AU - Gao,R L, AU - Chen,J L, AU - Chen,Z J, PY - 2003/8/9/pubmed PY - 2004/3/17/medline PY - 2003/8/9/entrez SP - 476 EP - 80 JF - Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae JO - Zhongguo Yi Xue Ke Xue Yuan Xue Bao VL - 23 IS - 5 N2 - OBJECTIVE: To compare the effects of carvedilol and metoprolol in preventing from left ventricular remodeling (LVRM) after acute myocardial infarction (AMI) in rats. METHODS: Twenty-four hours after ligating left coronary artery, 105 surviving female SD rats were randomly assigned to AMI control, carvedilol 1 mg/(kg.d) and metoprolol 2 mg/(kg.d) groups. Sham-operated rats (n = 16) were selected randomly as non-infarction control. After four weeks of drugs therapy, hemodynamic studies and pathologic analysis were performed. Exclusive of MI size < 35% or > 55%, complete experimental variables were obtained in 46 rats, which were comprised of AMI (n = 11), carvedilol (n = 12), metoprolol (n = 11), and Sham-operated (n = 12) groups. RESULTS: Compared with sham-operated group, left ventricular (LV) end diastolic pressure (LVEDP), volume (LVV) and weight (LVW), were all significantly increased (P < 0.05-0.001), while maximal rate of rise and fall (+/- dp/dt) of LV pressure as well as their corrected values (+/- dp/dt/LVSP) were all significantly decreased (P < 0.01-0.001) in AMI group. In comparison with AMI group, the LVEDP and LVV were all significantly decreased (all P < 0.001), while +/- dp/dt and +/- dp/dt/LVSP were significantly increased (P < 0.05-0.001) in both carvedilol and metoprolol group, with LVW and RVW only decreased in carvedilol group (P < 0.05-0.01). CONCLUSIONS: 1. Carvedilol can effectively attenuate LVRM, and improve hemodynamics and LV function after AMI in rats, 2. Metoprolol has equivalent beneficial effects as carvedilol on hemodynamics, LV dilatation and function, but not LV hypertrophy. SN - 1000-503X UR - https://www.unboundmedicine.com/medline/citation/12905866/[Comparative_effects_of_carvedilol_and_metoprolol_in_preventing_from_left_ventricular_remodeling_after_acute_myocardial_infarction_in_rats]_ L2 - https://medlineplus.gov/heartattack.html DB - PRIME DP - Unbound Medicine ER -