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Effects of milk products fermented by Bifidobacterium longum on blood lipids in rats and healthy adult male volunteers.

Abstract

The effects of milk products fermented by Bifidobacterium longum strain BL1, a probiotic strain, on blood lipids in rats and humans were studied. Rats were fed a cholesterol-enriched experimental diet, supplemented with lyophilized powders of 1) acid milk (control), 2) milk fermented with a mixed culture of ordinary yogurt starters composed of Streptococcus thermophilus and Lactobacillus delbrueckii subsp. bulgaricus (SL), and 3) bifidobacterium milk fermented with the probiotic B. longum strain BL1, respectively. The bifidobacterium milk feeding brought about significant lowering of the serum concentrations of total cholesterol, low-density lipoprotein cholesterol, and triglycerides, in comparison with the control, while no change in high-density lipoprotein cholesterol concentration was observed. On the other hand, supplementation with SL milk resulted in only slight, nonsignificant decreases in serum lipid concentrations in comparison with the control. In the human study, 32 subjects with serum total cholesterol ranging from 220 to 280 mg/dl were randomly assigned to two treatments: 1) intake of a low-fat drinking yogurt prepared with ordinary yogurt starters composed of S. thermophilus and L. delbrueckii subsp. bulgaricus (P-group) and 2) intake of a low-fat drinking yogurt prepared with the two ordinary yogurt starters plus B. longum strain BL1 (B-group). After intake for 4 wk at 3 x 100 ml/day, reduction of serum total cholesterol was observed in approximately half of the B-group subjects; a particularly significant decrease in serum total cholesterol was found among subjects with moderate hypercholesterolemia (serum total cholesterol > 240 mg/dl). However, the serum lipid concentrations in the P-group subjects were almost stable during the experimental periods. The present results indicate the potential of the probiotic B. longum strain BL1 in serum lipid improvement.

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  • Authors+Show Affiliations

    ,

    Food Research and Development Laboratory, Morinaga Milk Industry Co., Ltd., Zama 228-8583, Japan. j_xiao@morinagamilk.co.jp

    , , , , , , ,

    Source

    Journal of dairy science 86:7 2003 Jul pg 2452-61

    MeSH

    Adult
    Animals
    Bifidobacterium
    Bile
    Cholesterol
    Cholesterol, LDL
    Dairy Products
    Fermentation
    Gastric Juice
    Humans
    Hypercholesterolemia
    Lipids
    Male
    Middle Aged
    Milk
    Placebos
    Probiotics
    Rats
    Rats, Sprague-Dawley
    Triglycerides
    Yogurt

    Pub Type(s)

    Clinical Trial
    Journal Article
    Randomized Controlled Trial

    Language

    eng

    PubMed ID

    12906063

    Citation

    Xiao, J Z., et al. "Effects of Milk Products Fermented By Bifidobacterium Longum On Blood Lipids in Rats and Healthy Adult Male Volunteers." Journal of Dairy Science, vol. 86, no. 7, 2003, pp. 2452-61.
    Xiao JZ, Kondo S, Takahashi N, et al. Effects of milk products fermented by Bifidobacterium longum on blood lipids in rats and healthy adult male volunteers. J Dairy Sci. 2003;86(7):2452-61.
    Xiao, J. Z., Kondo, S., Takahashi, N., Miyaji, K., Oshida, K., Hiramatsu, A., ... Hosono, A. (2003). Effects of milk products fermented by Bifidobacterium longum on blood lipids in rats and healthy adult male volunteers. Journal of Dairy Science, 86(7), pp. 2452-61.
    Xiao JZ, et al. Effects of Milk Products Fermented By Bifidobacterium Longum On Blood Lipids in Rats and Healthy Adult Male Volunteers. J Dairy Sci. 2003;86(7):2452-61. PubMed PMID: 12906063.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effects of milk products fermented by Bifidobacterium longum on blood lipids in rats and healthy adult male volunteers. AU - Xiao,J Z, AU - Kondo,S, AU - Takahashi,N, AU - Miyaji,K, AU - Oshida,K, AU - Hiramatsu,A, AU - Iwatsuki,K, AU - Kokubo,S, AU - Hosono,A, PY - 2003/8/9/pubmed PY - 2003/9/27/medline PY - 2003/8/9/entrez SP - 2452 EP - 61 JF - Journal of dairy science JO - J. Dairy Sci. VL - 86 IS - 7 N2 - The effects of milk products fermented by Bifidobacterium longum strain BL1, a probiotic strain, on blood lipids in rats and humans were studied. Rats were fed a cholesterol-enriched experimental diet, supplemented with lyophilized powders of 1) acid milk (control), 2) milk fermented with a mixed culture of ordinary yogurt starters composed of Streptococcus thermophilus and Lactobacillus delbrueckii subsp. bulgaricus (SL), and 3) bifidobacterium milk fermented with the probiotic B. longum strain BL1, respectively. The bifidobacterium milk feeding brought about significant lowering of the serum concentrations of total cholesterol, low-density lipoprotein cholesterol, and triglycerides, in comparison with the control, while no change in high-density lipoprotein cholesterol concentration was observed. On the other hand, supplementation with SL milk resulted in only slight, nonsignificant decreases in serum lipid concentrations in comparison with the control. In the human study, 32 subjects with serum total cholesterol ranging from 220 to 280 mg/dl were randomly assigned to two treatments: 1) intake of a low-fat drinking yogurt prepared with ordinary yogurt starters composed of S. thermophilus and L. delbrueckii subsp. bulgaricus (P-group) and 2) intake of a low-fat drinking yogurt prepared with the two ordinary yogurt starters plus B. longum strain BL1 (B-group). After intake for 4 wk at 3 x 100 ml/day, reduction of serum total cholesterol was observed in approximately half of the B-group subjects; a particularly significant decrease in serum total cholesterol was found among subjects with moderate hypercholesterolemia (serum total cholesterol > 240 mg/dl). However, the serum lipid concentrations in the P-group subjects were almost stable during the experimental periods. The present results indicate the potential of the probiotic B. longum strain BL1 in serum lipid improvement. SN - 0022-0302 UR - https://www.unboundmedicine.com/medline/citation/12906063/Effects_of_milk_products_fermented_by_Bifidobacterium_longum_on_blood_lipids_in_rats_and_healthy_adult_male_volunteers_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-0302(03)73839-9 DB - PRIME DP - Unbound Medicine ER -