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Influence of age and gender on gastric acid secretion as estimated by integrated acidity in patients referred for 24-hour ambulatory pH monitoring.
Am J Gastroenterol 2003; 98(8):1713-8AJ

Abstract

OBJECTIVES

Earlier studies have suggested that gastric acid secretion declines with age. Integrated acidity (IA) calculated from ambulatory 24-h pH studies provides an estimation of gastric acid secretion that is less cumbersome than nasogastric aspiration. The aim of this study was to calculate IA as a function of age and gender.

METHODS

In a retrospective study, 753 ambulatory 24-h pH studies from 1994 to 2001 were analyzed. Subjects were classified according to nine age groups: <35 yr (n = 124), 35-39 yr (n = 90), 40-44 yr (n = 92), 45-49 yr (n = 111), 50-54 yr (n = 96), 55-59 yr (n = 61), 60-64 yr (n = 59), 65-69 yr (n = 42), and > or =70 yr (n = 64). Basal integrated acidity (BIA) was defined as IA between 12 midnight and 8 AM when no meals were consumed. Daytime and nocturnal IA/h was measured from 8 AM to 8 PM and from 8 PM to 8 AM. Postprandial IA (PIA) was measured for 2 h after the largest meal peak in each patient.

RESULTS

Gender distribution was similar between groups (chi(2) = 6.42, 3 df, p = 0.093). Mean gastric pH was similar between genders (2.96 +/- 1.36 women; 3.01 +/- 1.42 men; p = 0.71). Women and men had similar BIA (361.1 +/- 384.1 vs 434.6 +/- 436.6 mmol/L/h, p = 0.10), daytime IA (33.5 +/- 33.0 vs 34.1 +/- 33.7 mmol/L, p = 0.90) and nocturnal IA (43.3 +/- 42.1 vs 48.0 +/- 46.6 mmol/L, p = 0.42), and PIA (38.2 +/- 58.7 vs 36.0 +/- 58.5 mmol/L/h, p = 0.47). Mean gastric pH, daytime and nocturnal IA, BIA, and PIA did not differ between age groups (p > 0.1). None of the parameters studied had a linear association with age (mean gastric pH, r = 0.106; BIA, r = -0.124; daytime IA, r = -0.046; nocturnal IA, r = -0.104; PIA, r = -0.117).

CONCLUSIONS

Based on this study, we conclude that IA is unaffected by gender or age.

Authors+Show Affiliations

Division of Gastroenterology, University of Pennsylvania Health Systems, Philadelphia, Pennsylvania 19104, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12907323

Citation

Shih, Grace L., et al. "Influence of Age and Gender On Gastric Acid Secretion as Estimated By Integrated Acidity in Patients Referred for 24-hour Ambulatory pH Monitoring." The American Journal of Gastroenterology, vol. 98, no. 8, 2003, pp. 1713-8.
Shih GL, Brensinger C, Katzka DA, et al. Influence of age and gender on gastric acid secretion as estimated by integrated acidity in patients referred for 24-hour ambulatory pH monitoring. Am J Gastroenterol. 2003;98(8):1713-8.
Shih, G. L., Brensinger, C., Katzka, D. A., & Metz, D. C. (2003). Influence of age and gender on gastric acid secretion as estimated by integrated acidity in patients referred for 24-hour ambulatory pH monitoring. The American Journal of Gastroenterology, 98(8), pp. 1713-8.
Shih GL, et al. Influence of Age and Gender On Gastric Acid Secretion as Estimated By Integrated Acidity in Patients Referred for 24-hour Ambulatory pH Monitoring. Am J Gastroenterol. 2003;98(8):1713-8. PubMed PMID: 12907323.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of age and gender on gastric acid secretion as estimated by integrated acidity in patients referred for 24-hour ambulatory pH monitoring. AU - Shih,Grace L, AU - Brensinger,Colleen, AU - Katzka,David A, AU - Metz,David C, PY - 2003/8/9/pubmed PY - 2003/9/30/medline PY - 2003/8/9/entrez SP - 1713 EP - 8 JF - The American journal of gastroenterology JO - Am. J. Gastroenterol. VL - 98 IS - 8 N2 - OBJECTIVES: Earlier studies have suggested that gastric acid secretion declines with age. Integrated acidity (IA) calculated from ambulatory 24-h pH studies provides an estimation of gastric acid secretion that is less cumbersome than nasogastric aspiration. The aim of this study was to calculate IA as a function of age and gender. METHODS: In a retrospective study, 753 ambulatory 24-h pH studies from 1994 to 2001 were analyzed. Subjects were classified according to nine age groups: <35 yr (n = 124), 35-39 yr (n = 90), 40-44 yr (n = 92), 45-49 yr (n = 111), 50-54 yr (n = 96), 55-59 yr (n = 61), 60-64 yr (n = 59), 65-69 yr (n = 42), and > or =70 yr (n = 64). Basal integrated acidity (BIA) was defined as IA between 12 midnight and 8 AM when no meals were consumed. Daytime and nocturnal IA/h was measured from 8 AM to 8 PM and from 8 PM to 8 AM. Postprandial IA (PIA) was measured for 2 h after the largest meal peak in each patient. RESULTS: Gender distribution was similar between groups (chi(2) = 6.42, 3 df, p = 0.093). Mean gastric pH was similar between genders (2.96 +/- 1.36 women; 3.01 +/- 1.42 men; p = 0.71). Women and men had similar BIA (361.1 +/- 384.1 vs 434.6 +/- 436.6 mmol/L/h, p = 0.10), daytime IA (33.5 +/- 33.0 vs 34.1 +/- 33.7 mmol/L, p = 0.90) and nocturnal IA (43.3 +/- 42.1 vs 48.0 +/- 46.6 mmol/L, p = 0.42), and PIA (38.2 +/- 58.7 vs 36.0 +/- 58.5 mmol/L/h, p = 0.47). Mean gastric pH, daytime and nocturnal IA, BIA, and PIA did not differ between age groups (p > 0.1). None of the parameters studied had a linear association with age (mean gastric pH, r = 0.106; BIA, r = -0.124; daytime IA, r = -0.046; nocturnal IA, r = -0.104; PIA, r = -0.117). CONCLUSIONS: Based on this study, we conclude that IA is unaffected by gender or age. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/12907323/Influence_of_age_and_gender_on_gastric_acid_secretion_as_estimated_by_integrated_acidity_in_patients_referred_for_24_hour_ambulatory_pH_monitoring_ L2 - http://Insights.ovid.com/pubmed?pmid=12907323 DB - PRIME DP - Unbound Medicine ER -