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Should chronic obstructive pulmonary disease outpatients be routinely evaluated for trace elements?
Biol Trace Elem Res 2003; 94(1):41-8BT

Abstract

We searched for serum concentrations of trace elements and correlated them to malondialdehyde (MDA), which is an indirect marker of oxidative stress, in order to clarify if routine evaluation is necessary in chronic obstructive pulmonary disease (COPD) outpatients. Serum concentrations of copper (Cu), zinc (Zn), and magnesium (Mg) were determined by atomic absorption spectrophotometry and iron (Fe) by a ILLab 1800 autoanalyzer with ILLab test kits. Serum MDA concentrations were detected in terms of TBARS (thiobarbituric acid reactive substances) spectrophotometrically. Serum Cu, Zn, Mg, Fe, and MDA concentrations in patient and control groups were all in the normal reference range. The results respectively were as follows: Cu:123 +/- 29.2 and 122.2 +/- 23.4 microg/dL; Zn: 87.8 +/- 17.8 and 96.9 +/- 12.9 microg/dL; Mg: 2.3 +/- 0,5 and 2.04 +/- 0.28 mg/dL; Fe: 73.8 +/-35.5 and 80.7+/-51.2 microg/dL; MDA: 1.09+/-0.11 and 0.95+/-0.06 nmol/L. MDA was not correlated to Cu, Zn, Mg, or Fe (p>0.05 for all). The serum Zn concentration of COPD group was lower than the control group (p=0.042), whereas the Mg concentration was higher (p=0.021). There was no statistical difference in other study parameters. Oxidative stress was not increased in clinically stable, regularly treated COPD patients. Although there was no deficiency in trace elements (Cu, Fe, Mg, and Zn), serum Zn was close to the lower limit of the reference value. There is no need for routine evaluation of trace elements in clinically stable, regularly treated COPD outpatients.

Authors+Show Affiliations

Department of Biochemistry, Adnan Menderes University School of Medicine, Aydin, Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12907826

Citation

Karul, Aslihan B., et al. "Should Chronic Obstructive Pulmonary Disease Outpatients Be Routinely Evaluated for Trace Elements?" Biological Trace Element Research, vol. 94, no. 1, 2003, pp. 41-8.
Karul AB, Karadag F, Yensel N, et al. Should chronic obstructive pulmonary disease outpatients be routinely evaluated for trace elements? Biol Trace Elem Res. 2003;94(1):41-8.
Karul, A. B., Karadag, F., Yensel, N., Altinisik, M., Altun, C., & Cildag, O. (2003). Should chronic obstructive pulmonary disease outpatients be routinely evaluated for trace elements? Biological Trace Element Research, 94(1), pp. 41-8.
Karul AB, et al. Should Chronic Obstructive Pulmonary Disease Outpatients Be Routinely Evaluated for Trace Elements. Biol Trace Elem Res. 2003;94(1):41-8. PubMed PMID: 12907826.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Should chronic obstructive pulmonary disease outpatients be routinely evaluated for trace elements? AU - Karul,Aslihan B, AU - Karadag,Fisun, AU - Yensel,Naciye, AU - Altinisik,Mustafa, AU - Altun,Cagatay, AU - Cildag,Orhan, PY - 2002/09/04/received PY - 2002/11/04/accepted PY - 2003/8/9/pubmed PY - 2004/4/3/medline PY - 2003/8/9/entrez SP - 41 EP - 8 JF - Biological trace element research JO - Biol Trace Elem Res VL - 94 IS - 1 N2 - We searched for serum concentrations of trace elements and correlated them to malondialdehyde (MDA), which is an indirect marker of oxidative stress, in order to clarify if routine evaluation is necessary in chronic obstructive pulmonary disease (COPD) outpatients. Serum concentrations of copper (Cu), zinc (Zn), and magnesium (Mg) were determined by atomic absorption spectrophotometry and iron (Fe) by a ILLab 1800 autoanalyzer with ILLab test kits. Serum MDA concentrations were detected in terms of TBARS (thiobarbituric acid reactive substances) spectrophotometrically. Serum Cu, Zn, Mg, Fe, and MDA concentrations in patient and control groups were all in the normal reference range. The results respectively were as follows: Cu:123 +/- 29.2 and 122.2 +/- 23.4 microg/dL; Zn: 87.8 +/- 17.8 and 96.9 +/- 12.9 microg/dL; Mg: 2.3 +/- 0,5 and 2.04 +/- 0.28 mg/dL; Fe: 73.8 +/-35.5 and 80.7+/-51.2 microg/dL; MDA: 1.09+/-0.11 and 0.95+/-0.06 nmol/L. MDA was not correlated to Cu, Zn, Mg, or Fe (p>0.05 for all). The serum Zn concentration of COPD group was lower than the control group (p=0.042), whereas the Mg concentration was higher (p=0.021). There was no statistical difference in other study parameters. Oxidative stress was not increased in clinically stable, regularly treated COPD patients. Although there was no deficiency in trace elements (Cu, Fe, Mg, and Zn), serum Zn was close to the lower limit of the reference value. There is no need for routine evaluation of trace elements in clinically stable, regularly treated COPD outpatients. SN - 0163-4984 UR - https://www.unboundmedicine.com/medline/citation/12907826/Should_chronic_obstructive_pulmonary_disease_outpatients_be_routinely_evaluated_for_trace_elements L2 - https://dx.doi.org/10.1385/BTER:94:1:41 DB - PRIME DP - Unbound Medicine ER -