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Properties of drug-containing spherical pellets produced by a hot-melt extrusion and spheronization process.
J Microencapsul. 2003 Sep-Oct; 20(5):613-25.JM

Abstract

The objectives of this study were to investigate the particle size distribution, morphology and dissolution properties of spherical pellets produced by hot-melt extrusion and spheronization and to compare the properties of hot-melt extruded pellets with beads manufactured by a traditional wet-mass extrusion and spheronization method. Spherical pellets were produced by hot-melt extrusion without the use of water or other solvents. A powder blend of theophylline, Eudragit Preparation 4135 F, microcrystalline cellulose and polyethylene glycol 8000 was hot melt-extruded and the resulting composite rod was cut into cylindrical pellets. The pellets were then spheronized in a traditional spheronizer at an elevated temperature. The same powder blend was processed using conventional wet-mass techniques. Unlike wet-mass extruded pellets, pellets prepared from hot-melt extrusion displayed both a narrow particle size distribution and controlled drug release in dissolution media less than pH 7.4. Scanning electron microscopy, X-ray diffraction and porosity measurements were employed to explain the differences in drug release rates of theophylline from pellets produced by the two processing techniques. Theophylline release from the hot-melt extruded pellets was described using the Higuchi diffusion model, and drug release rates from wet-granulated and melt-extruded pellets did not change after post-processing thermal treatment.

Authors+Show Affiliations

Young CR
Drug Dynamics Institute, College of Pharmacy, The University of Texas at Austin, 78712, USA. chris.young@mail.utexas.edu
Koleng JJ
No affiliation info available
McGinity JW
No affiliation info available

MeSH

Biocompatible MaterialsCelluloseDelayed-Action PreparationsDiffusionDrug CompoundingDrug ImplantsGelsHot TemperatureHydrogen-Ion ConcentrationMicroscopy, Electron, ScanningParticle SizePolyethylene GlycolsPolymethacrylic AcidsPorosityTheophyllineX-Ray Diffraction

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12909545

Citation

Young, C R., et al. "Properties of Drug-containing Spherical Pellets Produced By a Hot-melt Extrusion and Spheronization Process." Journal of Microencapsulation, vol. 20, no. 5, 2003, pp. 613-25.
Young CR, Koleng JJ, McGinity JW. Properties of drug-containing spherical pellets produced by a hot-melt extrusion and spheronization process. J Microencapsul. 2003;20(5):613-25.
Young, C. R., Koleng, J. J., & McGinity, J. W. (2003). Properties of drug-containing spherical pellets produced by a hot-melt extrusion and spheronization process. Journal of Microencapsulation, 20(5), 613-25.
Young CR, Koleng JJ, McGinity JW. Properties of Drug-containing Spherical Pellets Produced By a Hot-melt Extrusion and Spheronization Process. J Microencapsul. 2003 Sep-Oct;20(5):613-25. PubMed PMID: 12909545.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Properties of drug-containing spherical pellets produced by a hot-melt extrusion and spheronization process. AU - Young,C R, AU - Koleng,J J, AU - McGinity,J W, PY - 2003/8/12/pubmed PY - 2003/11/7/medline PY - 2003/8/12/entrez SP - 613 EP - 25 JF - Journal of microencapsulation JO - J Microencapsul VL - 20 IS - 5 N2 - The objectives of this study were to investigate the particle size distribution, morphology and dissolution properties of spherical pellets produced by hot-melt extrusion and spheronization and to compare the properties of hot-melt extruded pellets with beads manufactured by a traditional wet-mass extrusion and spheronization method. Spherical pellets were produced by hot-melt extrusion without the use of water or other solvents. A powder blend of theophylline, Eudragit Preparation 4135 F, microcrystalline cellulose and polyethylene glycol 8000 was hot melt-extruded and the resulting composite rod was cut into cylindrical pellets. The pellets were then spheronized in a traditional spheronizer at an elevated temperature. The same powder blend was processed using conventional wet-mass techniques. Unlike wet-mass extruded pellets, pellets prepared from hot-melt extrusion displayed both a narrow particle size distribution and controlled drug release in dissolution media less than pH 7.4. Scanning electron microscopy, X-ray diffraction and porosity measurements were employed to explain the differences in drug release rates of theophylline from pellets produced by the two processing techniques. Theophylline release from the hot-melt extruded pellets was described using the Higuchi diffusion model, and drug release rates from wet-granulated and melt-extruded pellets did not change after post-processing thermal treatment. SN - 0265-2048 UR - https://www.unboundmedicine.com/medline/citation/12909545/Properties_of_drug_containing_spherical_pellets_produced_by_a_hot_melt_extrusion_and_spheronization_process_ DB - PRIME DP - Unbound Medicine ER -