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[Two cases of non-functional gonadotroph adenoma pituitary apoplexy following GnRH-agonist treatment revealing gonadotroph adenoma and pseudopituitary apoplexy after GnRH administration].
Ann Endocrinol (Paris). 2003 Jun; 64(3):227-31.AE

Abstract

We report here two cases of pituitary apoplexy or pseudoapoplexy revealing a gonadotroph adenoma. A 69-year-old man, who had just started antiandrogen treatment (Gn-RH agonist) for prostatic cancer, was admitted to neurosurgery emergency because of increasing headache and visual impairment. The CT-scan disclosed the presence of a large pituitary mass with lateral invasion of the left cavernous sinus. Hormonel testing showed panhypopituitarism. A few days later, diabetes insipidus appeared. The patient first received corticosteroid therapy and underwent surgical adenomectomy. Immunostaining of the tumor tissue was positive for FSHbeta, confirming the diagnosis of gonadotroph adenoma. Three months after surgery, the endocrine evaluation showed pituitary insufficiency. An 81-year-old man complained of mnemonic disorders. The CT-scan revealed a pituitary mass without extension. The Ophthalmological examination showed left temporal upper quadranopsia. Endocrinological tests with administration of GN-HR triggered headache and vomiting. A second CT-scan was unchanged. Hormone testing revealed increased serum levels of FSH and decreased serum levels of LH. Surgical management of the primary tumor was undertaken due to the visual field alteration. Immunohistochemical studies confirmed the diagnosis of gonadotroph FSHbeta adenoma.

Authors+Show Affiliations

Hernandez Morin N
Service d'Endocrinologie et Métabolisme, Hôpital Saint-Joseph, 185, rue Raymond Losserand, 75014 Paris. nelly.morin@club-internet.fr
Huet D
No affiliation info available
Hautecouverture M
No affiliation info available

MeSH

AdenomaAgedAged, 80 and overFollicle Stimulating HormoneFollicle Stimulating Hormone, beta SubunitGonadotropin-Releasing HormoneHumansLeuprolideLuteinizing HormoneMalePituitary ApoplexyPituitary NeoplasmsProstatic NeoplasmsTomography, X-Ray Computed

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

fre

PubMed ID

12910066

Citation

Hernandez Morin, N, et al. "[Two Cases of Non-functional Gonadotroph Adenoma Pituitary Apoplexy Following GnRH-agonist Treatment Revealing Gonadotroph Adenoma and Pseudopituitary Apoplexy After GnRH Administration]." Annales D'endocrinologie, vol. 64, no. 3, 2003, pp. 227-31.
Hernandez Morin N, Huet D, Hautecouverture M. [Two cases of non-functional gonadotroph adenoma pituitary apoplexy following GnRH-agonist treatment revealing gonadotroph adenoma and pseudopituitary apoplexy after GnRH administration]. Ann Endocrinol (Paris). 2003;64(3):227-31.
Hernandez Morin, N., Huet, D., & Hautecouverture, M. (2003). [Two cases of non-functional gonadotroph adenoma pituitary apoplexy following GnRH-agonist treatment revealing gonadotroph adenoma and pseudopituitary apoplexy after GnRH administration]. Annales D'endocrinologie, 64(3), 227-31.
Hernandez Morin N, Huet D, Hautecouverture M. [Two Cases of Non-functional Gonadotroph Adenoma Pituitary Apoplexy Following GnRH-agonist Treatment Revealing Gonadotroph Adenoma and Pseudopituitary Apoplexy After GnRH Administration]. Ann Endocrinol (Paris). 2003;64(3):227-31. PubMed PMID: 12910066.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Two cases of non-functional gonadotroph adenoma pituitary apoplexy following GnRH-agonist treatment revealing gonadotroph adenoma and pseudopituitary apoplexy after GnRH administration]. AU - Hernandez Morin,N, AU - Huet,D, AU - Hautecouverture,M, PY - 2003/8/12/pubmed PY - 2003/10/28/medline PY - 2003/8/12/entrez SP - 227 EP - 31 JF - Annales d'endocrinologie JO - Ann Endocrinol (Paris) VL - 64 IS - 3 N2 - We report here two cases of pituitary apoplexy or pseudoapoplexy revealing a gonadotroph adenoma. A 69-year-old man, who had just started antiandrogen treatment (Gn-RH agonist) for prostatic cancer, was admitted to neurosurgery emergency because of increasing headache and visual impairment. The CT-scan disclosed the presence of a large pituitary mass with lateral invasion of the left cavernous sinus. Hormonel testing showed panhypopituitarism. A few days later, diabetes insipidus appeared. The patient first received corticosteroid therapy and underwent surgical adenomectomy. Immunostaining of the tumor tissue was positive for FSHbeta, confirming the diagnosis of gonadotroph adenoma. Three months after surgery, the endocrine evaluation showed pituitary insufficiency. An 81-year-old man complained of mnemonic disorders. The CT-scan revealed a pituitary mass without extension. The Ophthalmological examination showed left temporal upper quadranopsia. Endocrinological tests with administration of GN-HR triggered headache and vomiting. A second CT-scan was unchanged. Hormone testing revealed increased serum levels of FSH and decreased serum levels of LH. Surgical management of the primary tumor was undertaken due to the visual field alteration. Immunohistochemical studies confirmed the diagnosis of gonadotroph FSHbeta adenoma. SN - 0003-4266 UR - https://www.unboundmedicine.com/medline/citation/12910066/[Two_cases_of_non_functional_gonadotroph_adenoma_pituitary_apoplexy_following_GnRH_agonist_treatment_revealing_gonadotroph_adenoma_and_pseudopituitary_apoplexy_after_GnRH_administration]_ DB - PRIME DP - Unbound Medicine ER -