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Prostate cancer is part of the hereditary non-polyposis colorectal cancer (HNPCC) tumor spectrum.
. 2003 Aug 30; 121A(2):159-62.

Abstract

The recognized urologic tumor spectrum in hereditary non-polyposis colon cancer includes ureteral and renal pelvis malignancies. Here, we report a family in which the proband, who had three metachronous adenocarcinomas of the colon and rectum (at ages 54, 57, and 60), presented with an adenocarcinoma of the prostate at age 61. Immunohistochemical (IHC) staining of colonic, rectal, and prostatic tumor tissues demonstrated lack of expression of both MSH2 and MSH6. Accordingly, microsatellite instability (MSI) was found in the rectal, colonic, and prostatic tumors. The kindred complies with the Amsterdam criteria for HNPCC, as five members over three generations had colorectal cancer. Molecular investigations were initiated when the proband's son presented with an adenocarcinoma of the colon at age 35. Southern blotting analysis of genomic DNA led to identification of a novel genomic deletion encompassing exon 5 of the MSH2 gene. Although prostate cancer has occasionally been described in HNPCC families, to the best of our knowledge, this is the first report where the MSI and IHC analysis of the prostatic adenomcarcinoma clearly link its aetiology to the germline mismatch repair mutation. Hence, prostate cancer should be included in the HNPCC tumor spectrum.

Authors+Show Affiliations

Clinic of Digestive Surgery, Geneva University Hospital, Geneva, Switzerland. csoravia@hin.chNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

12910497

Citation

Soravia, Claudio, et al. "Prostate Cancer Is Part of the Hereditary Non-polyposis Colorectal Cancer (HNPCC) Tumor Spectrum." American Journal of Medical Genetics. Part A, vol. 121A, no. 2, 2003, pp. 159-62.
Soravia C, van der Klift H, Bründler MA, et al. Prostate cancer is part of the hereditary non-polyposis colorectal cancer (HNPCC) tumor spectrum. Am J Med Genet A. 2003;121A(2):159-62.
Soravia, C., van der Klift, H., Bründler, M. A., Blouin, J. L., Wijnen, J., Hutter, P., Fodde, R., & Delozier-Blanchet, C. (2003). Prostate cancer is part of the hereditary non-polyposis colorectal cancer (HNPCC) tumor spectrum. American Journal of Medical Genetics. Part A, 121A(2), 159-62.
Soravia C, et al. Prostate Cancer Is Part of the Hereditary Non-polyposis Colorectal Cancer (HNPCC) Tumor Spectrum. Am J Med Genet A. 2003 Aug 30;121A(2):159-62. PubMed PMID: 12910497.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prostate cancer is part of the hereditary non-polyposis colorectal cancer (HNPCC) tumor spectrum. AU - Soravia,Claudio, AU - van der Klift,Heleen, AU - Bründler,Marie-Anne, AU - Blouin,Jean-Louis, AU - Wijnen,Juul, AU - Hutter,Pierre, AU - Fodde,Riccardo, AU - Delozier-Blanchet,Célia, PY - 2003/8/12/pubmed PY - 2004/4/29/medline PY - 2003/8/12/entrez SP - 159 EP - 62 JF - American journal of medical genetics. Part A JO - Am. J. Med. Genet. A VL - 121A IS - 2 N2 - The recognized urologic tumor spectrum in hereditary non-polyposis colon cancer includes ureteral and renal pelvis malignancies. Here, we report a family in which the proband, who had three metachronous adenocarcinomas of the colon and rectum (at ages 54, 57, and 60), presented with an adenocarcinoma of the prostate at age 61. Immunohistochemical (IHC) staining of colonic, rectal, and prostatic tumor tissues demonstrated lack of expression of both MSH2 and MSH6. Accordingly, microsatellite instability (MSI) was found in the rectal, colonic, and prostatic tumors. The kindred complies with the Amsterdam criteria for HNPCC, as five members over three generations had colorectal cancer. Molecular investigations were initiated when the proband's son presented with an adenocarcinoma of the colon at age 35. Southern blotting analysis of genomic DNA led to identification of a novel genomic deletion encompassing exon 5 of the MSH2 gene. Although prostate cancer has occasionally been described in HNPCC families, to the best of our knowledge, this is the first report where the MSI and IHC analysis of the prostatic adenomcarcinoma clearly link its aetiology to the germline mismatch repair mutation. Hence, prostate cancer should be included in the HNPCC tumor spectrum. SN - 1552-4825 UR - https://www.unboundmedicine.com/medline/citation/12910497/Prostate_cancer_is_part_of_the_hereditary_non_polyposis_colorectal_cancer__HNPCC__tumor_spectrum_ L2 - https://doi.org/10.1002/ajmg.a.20106 DB - PRIME DP - Unbound Medicine ER -