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Progressive decrease of left Heschl gyrus and planum temporale gray matter volume in first-episode schizophrenia: a longitudinal magnetic resonance imaging study.
Arch Gen Psychiatry 2003; 60(8):766-75AG

Abstract

BACKGROUND

The Heschl gyrus and planum temporale have crucial roles in auditory perception and language processing. Our previous investigation using magnetic resonance imaging (MRI) indicated smaller gray matter volumes bilaterally in the Heschl gyrus and in left planum temporale in patients with first-episode schizophrenia but not in patients with first-episode affective psychosis. We sought to determine whether there are progressive decreases in anatomically defined MRI gray matter volumes of the Heschl gyrus and planum temporale in patients with first-episode schizophrenia and also in patients with first-episode affective psychosis.

METHODS

At a private psychiatric hospital, we conducted a prospective high spatial resolution MRI study that included initial scans of 28 patients at their first hospitalization (13 with schizophrenia and 15 with affective psychosis, 13 of whom had a manic psychosis) and 22 healthy control subjects. Follow-up scans occurred, on average, 1.5 years after the initial scan.

RESULTS

Patients with first-episode schizophrenia showed significant decreases in gray matter volume over time in the left Heschl gyrus (6.9%) and left planum temporale (7.2%) compared with patients with first-episode affective psychosis or control subjects.

CONCLUSIONS

These findings demonstrate a left-biased progressive volume reduction in the Heschl gyrus and planum temporale gray matter in patients with first-episode schizophrenia in contrast to patients with first-episode affective psychosis and control subjects. Schizophrenia but not affective psychosis seems to be characterized by a postonset progression of neocortical gray matter volume loss in the left superior temporal gyrus and thus may not be developmentally fixed.

Authors+Show Affiliations

Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Veterans Affairs Boston Healthcare System, Brockton Division, Brockton, Mass, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12912760

Citation

Kasai, Kiyoto, et al. "Progressive Decrease of Left Heschl Gyrus and Planum Temporale Gray Matter Volume in First-episode Schizophrenia: a Longitudinal Magnetic Resonance Imaging Study." Archives of General Psychiatry, vol. 60, no. 8, 2003, pp. 766-75.
Kasai K, Shenton ME, Salisbury DF, et al. Progressive decrease of left Heschl gyrus and planum temporale gray matter volume in first-episode schizophrenia: a longitudinal magnetic resonance imaging study. Arch Gen Psychiatry. 2003;60(8):766-75.
Kasai, K., Shenton, M. E., Salisbury, D. F., Hirayasu, Y., Onitsuka, T., Spencer, M. H., ... McCarley, R. W. (2003). Progressive decrease of left Heschl gyrus and planum temporale gray matter volume in first-episode schizophrenia: a longitudinal magnetic resonance imaging study. Archives of General Psychiatry, 60(8), pp. 766-75.
Kasai K, et al. Progressive Decrease of Left Heschl Gyrus and Planum Temporale Gray Matter Volume in First-episode Schizophrenia: a Longitudinal Magnetic Resonance Imaging Study. Arch Gen Psychiatry. 2003;60(8):766-75. PubMed PMID: 12912760.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Progressive decrease of left Heschl gyrus and planum temporale gray matter volume in first-episode schizophrenia: a longitudinal magnetic resonance imaging study. AU - Kasai,Kiyoto, AU - Shenton,Martha E, AU - Salisbury,Dean F, AU - Hirayasu,Yoshio, AU - Onitsuka,Toshiaki, AU - Spencer,Magdalena H, AU - Yurgelun-Todd,Deborah A, AU - Kikinis,Ron, AU - Jolesz,Ferenc A, AU - McCarley,Robert W, PY - 2003/8/13/pubmed PY - 2003/9/11/medline PY - 2003/8/13/entrez SP - 766 EP - 75 JF - Archives of general psychiatry JO - Arch. Gen. Psychiatry VL - 60 IS - 8 N2 - BACKGROUND: The Heschl gyrus and planum temporale have crucial roles in auditory perception and language processing. Our previous investigation using magnetic resonance imaging (MRI) indicated smaller gray matter volumes bilaterally in the Heschl gyrus and in left planum temporale in patients with first-episode schizophrenia but not in patients with first-episode affective psychosis. We sought to determine whether there are progressive decreases in anatomically defined MRI gray matter volumes of the Heschl gyrus and planum temporale in patients with first-episode schizophrenia and also in patients with first-episode affective psychosis. METHODS: At a private psychiatric hospital, we conducted a prospective high spatial resolution MRI study that included initial scans of 28 patients at their first hospitalization (13 with schizophrenia and 15 with affective psychosis, 13 of whom had a manic psychosis) and 22 healthy control subjects. Follow-up scans occurred, on average, 1.5 years after the initial scan. RESULTS: Patients with first-episode schizophrenia showed significant decreases in gray matter volume over time in the left Heschl gyrus (6.9%) and left planum temporale (7.2%) compared with patients with first-episode affective psychosis or control subjects. CONCLUSIONS: These findings demonstrate a left-biased progressive volume reduction in the Heschl gyrus and planum temporale gray matter in patients with first-episode schizophrenia in contrast to patients with first-episode affective psychosis and control subjects. Schizophrenia but not affective psychosis seems to be characterized by a postonset progression of neocortical gray matter volume loss in the left superior temporal gyrus and thus may not be developmentally fixed. SN - 0003-990X UR - https://www.unboundmedicine.com/medline/citation/12912760/Progressive_decrease_of_left_Heschl_gyrus_and_planum_temporale_gray_matter_volume_in_first_episode_schizophrenia:_a_longitudinal_magnetic_resonance_imaging_study_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=12912760.ui DB - PRIME DP - Unbound Medicine ER -