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Nosocomial bloodstream infections in pediatric patients in United States hospitals: epidemiology, clinical features and susceptibilities.
Pediatr Infect Dis J. 2003 Aug; 22(8):686-91.PI

Abstract

BACKGROUND

We identified the predominant pathogens and antimicrobial susceptibilities of nosocomial bloodstream isolates in pediatric patients in the US Prospective surveillance for nosocomial bloodstream infections at 49 hospitals during a 6-year period [Surveillance and Control of Pathogens of Epidemiologic Importance (SCOPE)] detected 22 609 bloodstream infections, of which 3432 occurred in patients < or =16 years of age.

RESULTS

Gram-positive organisms accounted for 65% of cases, Gram-negative organisms accounted for 24% of cases and 11% were caused by fungi. The overall crude mortality was 14% (475 of 3432) but notably higher for infections caused by Candida spp. and Pseudomonas aeruginosa, 20 and 29%, respectively. The most common organisms were coagulase-negative staphylococci (43%), enterococci, Staphylococcus aureus and Candida spp. (each, 9%). The mean interval between admission and infection averaged 21 days for coagulase-negative staphylococci, 25 days for S. aureus and Candida spp., 32 days for Klebsiella spp. and 34 days for Enterococcus spp. The proportion of methicillin-resistant S. aureus increased from 10% in 1995 to 29% in 2001. Vancomycin-resistance was seen in 1% of Enterococcus faecalis and in 11% of Enterococcus faecium isolates.

CONCLUSION

Nosocomial BSI occurred predominantly in very young and/or critically ill children. Gram-positive pathogens predominated across all ages, and increasing antimicrobial resistance was observed in pediatric patients.

Authors+Show Affiliations

Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12913767

Citation

Wisplinghoff, Hilmar, et al. "Nosocomial Bloodstream Infections in Pediatric Patients in United States Hospitals: Epidemiology, Clinical Features and Susceptibilities." The Pediatric Infectious Disease Journal, vol. 22, no. 8, 2003, pp. 686-91.
Wisplinghoff H, Seifert H, Tallent SM, et al. Nosocomial bloodstream infections in pediatric patients in United States hospitals: epidemiology, clinical features and susceptibilities. Pediatr Infect Dis J. 2003;22(8):686-91.
Wisplinghoff, H., Seifert, H., Tallent, S. M., Bischoff, T., Wenzel, R. P., & Edmond, M. B. (2003). Nosocomial bloodstream infections in pediatric patients in United States hospitals: epidemiology, clinical features and susceptibilities. The Pediatric Infectious Disease Journal, 22(8), 686-91.
Wisplinghoff H, et al. Nosocomial Bloodstream Infections in Pediatric Patients in United States Hospitals: Epidemiology, Clinical Features and Susceptibilities. Pediatr Infect Dis J. 2003;22(8):686-91. PubMed PMID: 12913767.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nosocomial bloodstream infections in pediatric patients in United States hospitals: epidemiology, clinical features and susceptibilities. AU - Wisplinghoff,Hilmar, AU - Seifert,Harald, AU - Tallent,Sandra M, AU - Bischoff,Tammy, AU - Wenzel,Richard P, AU - Edmond,Michael B, PY - 2003/8/13/pubmed PY - 2003/9/27/medline PY - 2003/8/13/entrez SP - 686 EP - 91 JF - The Pediatric infectious disease journal JO - Pediatr Infect Dis J VL - 22 IS - 8 N2 - BACKGROUND: We identified the predominant pathogens and antimicrobial susceptibilities of nosocomial bloodstream isolates in pediatric patients in the US Prospective surveillance for nosocomial bloodstream infections at 49 hospitals during a 6-year period [Surveillance and Control of Pathogens of Epidemiologic Importance (SCOPE)] detected 22 609 bloodstream infections, of which 3432 occurred in patients < or =16 years of age. RESULTS: Gram-positive organisms accounted for 65% of cases, Gram-negative organisms accounted for 24% of cases and 11% were caused by fungi. The overall crude mortality was 14% (475 of 3432) but notably higher for infections caused by Candida spp. and Pseudomonas aeruginosa, 20 and 29%, respectively. The most common organisms were coagulase-negative staphylococci (43%), enterococci, Staphylococcus aureus and Candida spp. (each, 9%). The mean interval between admission and infection averaged 21 days for coagulase-negative staphylococci, 25 days for S. aureus and Candida spp., 32 days for Klebsiella spp. and 34 days for Enterococcus spp. The proportion of methicillin-resistant S. aureus increased from 10% in 1995 to 29% in 2001. Vancomycin-resistance was seen in 1% of Enterococcus faecalis and in 11% of Enterococcus faecium isolates. CONCLUSION: Nosocomial BSI occurred predominantly in very young and/or critically ill children. Gram-positive pathogens predominated across all ages, and increasing antimicrobial resistance was observed in pediatric patients. SN - 0891-3668 UR - https://www.unboundmedicine.com/medline/citation/12913767/Nosocomial_bloodstream_infections_in_pediatric_patients_in_United_States_hospitals:_epidemiology_clinical_features_and_susceptibilities_ L2 - https://doi.org/10.1097/01.inf.0000078159.53132.40 DB - PRIME DP - Unbound Medicine ER -