Tags

Type your tag names separated by a space and hit enter

Gtwnt-5 a member of the wnt family expressed in a subpopulation of the nervous system of the planarian Girardia tigrina.
Gene Expr Patterns 2003; 3(4):489-95GE

Abstract

Wnt proteins are a family of highly conserved secreted glycoproteins that regulate cell-to-cell interactions during embryogenesis. They act as signaling molecules and take part in many crucial decisions throughout the development of organisms ranging from Hydra to human. We have isolated and characterized the expression of a member of the Wnt family, Gtwnt-5 gene in the planarian Girardia tigrina. Planarians are free-living members (Class Turbellaria) of the Phylum Platyhelminthes. They are best known for their high regenerative capabilities. These organisms have an apparently simple central nervous system (CNS) from a morphological perspective, with cephalic ganglia in the dorsal anterior region and two ventral main nerve cords along the body. However, a large number of planarian neural genes have recently been identified and therefore it is possible to define different molecular and functional domains in the planarian brain. The present study shows expression of Gtwnt-5 in a subpopulation of the whole CNS of intact organisms, being activated during regeneration. Gtwnt-5 reveals a differential spatial pattern: the expression is preferentially found in the most external region of the CNS. In addition, a kind of iterative pattern has been observed at the ganglia level, suggesting that the planarian brain might not be a continuous structure but compartmented or regionalized. Gtwnt-5 signal is also detected at the sensors of the worm: at the auricle level and all around the cephalic periphery. All these data provide us with a new neural marker for the planarian brain, and can be used to follow regeneration of the CNS.

Authors+Show Affiliations

Departament de Genètica, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12915317

Citation

Marsal, Maria, et al. "Gtwnt-5 a Member of the Wnt Family Expressed in a Subpopulation of the Nervous System of the Planarian Girardia Tigrina." Gene Expression Patterns : GEP, vol. 3, no. 4, 2003, pp. 489-95.
Marsal M, Pineda D, Saló E. Gtwnt-5 a member of the wnt family expressed in a subpopulation of the nervous system of the planarian Girardia tigrina. Gene Expr Patterns. 2003;3(4):489-95.
Marsal, M., Pineda, D., & Saló, E. (2003). Gtwnt-5 a member of the wnt family expressed in a subpopulation of the nervous system of the planarian Girardia tigrina. Gene Expression Patterns : GEP, 3(4), pp. 489-95.
Marsal M, Pineda D, Saló E. Gtwnt-5 a Member of the Wnt Family Expressed in a Subpopulation of the Nervous System of the Planarian Girardia Tigrina. Gene Expr Patterns. 2003;3(4):489-95. PubMed PMID: 12915317.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gtwnt-5 a member of the wnt family expressed in a subpopulation of the nervous system of the planarian Girardia tigrina. AU - Marsal,Maria, AU - Pineda,David, AU - Saló,Emili, PY - 2003/8/14/pubmed PY - 2004/4/22/medline PY - 2003/8/14/entrez SP - 489 EP - 95 JF - Gene expression patterns : GEP JO - Gene Expr. Patterns VL - 3 IS - 4 N2 - Wnt proteins are a family of highly conserved secreted glycoproteins that regulate cell-to-cell interactions during embryogenesis. They act as signaling molecules and take part in many crucial decisions throughout the development of organisms ranging from Hydra to human. We have isolated and characterized the expression of a member of the Wnt family, Gtwnt-5 gene in the planarian Girardia tigrina. Planarians are free-living members (Class Turbellaria) of the Phylum Platyhelminthes. They are best known for their high regenerative capabilities. These organisms have an apparently simple central nervous system (CNS) from a morphological perspective, with cephalic ganglia in the dorsal anterior region and two ventral main nerve cords along the body. However, a large number of planarian neural genes have recently been identified and therefore it is possible to define different molecular and functional domains in the planarian brain. The present study shows expression of Gtwnt-5 in a subpopulation of the whole CNS of intact organisms, being activated during regeneration. Gtwnt-5 reveals a differential spatial pattern: the expression is preferentially found in the most external region of the CNS. In addition, a kind of iterative pattern has been observed at the ganglia level, suggesting that the planarian brain might not be a continuous structure but compartmented or regionalized. Gtwnt-5 signal is also detected at the sensors of the worm: at the auricle level and all around the cephalic periphery. All these data provide us with a new neural marker for the planarian brain, and can be used to follow regeneration of the CNS. SN - 1567-133X UR - https://www.unboundmedicine.com/medline/citation/12915317/Gtwnt_5_a_member_of_the_wnt_family_expressed_in_a_subpopulation_of_the_nervous_system_of_the_planarian_Girardia_tigrina_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1567133X03000589 DB - PRIME DP - Unbound Medicine ER -