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Hepatoprotective and antioxidant activities of Tetracera loureiri.
Phytother Res. 2003 Aug; 17(7):717-21.PR

Abstract

Tetracera loureiri is one of the most valued herbs in Thai traditional medicine. In this study, we describe its in vitro and in vivo antioxidant and hepatoprotective activities. The ethanol extract of T. loureiri possessed potent antioxidant and strong free radical scavenging properties assayed using ferric reducing antioxidant power (FRAP) and 2,2-diphenyl-1-picrylhydrazyl (DPPH), respectively. The cytoprotective effects of T. loureiri were demonstrated in ethanolic extracts of freshly isolated rat hepatocytes against the chemical toxicants paracetamol and tertiary-butylhydroperoxide. The cells pretreated with the extract maintained the GSH/GSSG ratio and suppressed lipid peroxidation in a dose dependent manner. Pretreating rats with the ethanol extract orally, one hour prior to intraperitoneal injection of toxic doses of paracetamol, significantly prevented elevations of plasma ALT and AST. These results suggest that T. loureiri may be of potential therapeutic value in some liver disorders.

Authors+Show Affiliations

Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand. veerap-k@md.kku.ac.thNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12916065

Citation

Kukongviriyapan, Veerapol, et al. "Hepatoprotective and Antioxidant Activities of Tetracera Loureiri." Phytotherapy Research : PTR, vol. 17, no. 7, 2003, pp. 717-21.
Kukongviriyapan V, Janyacharoen T, Kukongviriyapan U, et al. Hepatoprotective and antioxidant activities of Tetracera loureiri. Phytother Res. 2003;17(7):717-21.
Kukongviriyapan, V., Janyacharoen, T., Kukongviriyapan, U., Laupattarakasaem, P., Kanokmedhakul, S., & Chantaranothai, P. (2003). Hepatoprotective and antioxidant activities of Tetracera loureiri. Phytotherapy Research : PTR, 17(7), 717-21.
Kukongviriyapan V, et al. Hepatoprotective and Antioxidant Activities of Tetracera Loureiri. Phytother Res. 2003;17(7):717-21. PubMed PMID: 12916065.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatoprotective and antioxidant activities of Tetracera loureiri. AU - Kukongviriyapan,Veerapol, AU - Janyacharoen,Taweesak, AU - Kukongviriyapan,Upa, AU - Laupattarakasaem,Pisamai, AU - Kanokmedhakul,Somdej, AU - Chantaranothai,Pranom, PY - 2003/8/14/pubmed PY - 2003/12/18/medline PY - 2003/8/14/entrez SP - 717 EP - 21 JF - Phytotherapy research : PTR JO - Phytother Res VL - 17 IS - 7 N2 - Tetracera loureiri is one of the most valued herbs in Thai traditional medicine. In this study, we describe its in vitro and in vivo antioxidant and hepatoprotective activities. The ethanol extract of T. loureiri possessed potent antioxidant and strong free radical scavenging properties assayed using ferric reducing antioxidant power (FRAP) and 2,2-diphenyl-1-picrylhydrazyl (DPPH), respectively. The cytoprotective effects of T. loureiri were demonstrated in ethanolic extracts of freshly isolated rat hepatocytes against the chemical toxicants paracetamol and tertiary-butylhydroperoxide. The cells pretreated with the extract maintained the GSH/GSSG ratio and suppressed lipid peroxidation in a dose dependent manner. Pretreating rats with the ethanol extract orally, one hour prior to intraperitoneal injection of toxic doses of paracetamol, significantly prevented elevations of plasma ALT and AST. These results suggest that T. loureiri may be of potential therapeutic value in some liver disorders. SN - 0951-418X UR - https://www.unboundmedicine.com/medline/citation/12916065/Hepatoprotective_and_antioxidant_activities_of_Tetracera_loureiri_ DB - PRIME DP - Unbound Medicine ER -