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Dementia and Nutrition. Intervention study in institutionalized patients with Alzheimer disease.

Abstract

OBJECTIVES

To know nutritional status of a group of institutionalized patients with moderate Alzheimer's Disease (AD), and to ascertain the effects of an intervention with nutritional supplements on morbidity and mortality after one year follow-up.

PATIENTS AND METHODS

99 patients (mean age: 86.5 years), 80 women, with a diagnosis of AD according with NINCDS/ADRDA criteria, were recruited from 8 nursing-homes. 25 were included in an intervention group and received a nutritional supplements along 12 months. Evolution was evaluated according to the Functional Assessment Staging Test (FAST). Patients with FAST levels 5-6 were included. General clinical variables as well as variables reflecting cognitive state and nutritional status: anthropometric, biochemical data and Mini Nutritional Assessment (MNA) were analysed. Statistical analysis was carry out with the SPSS 10.0 package.

RESULTS

Mean time since diagnosis was 49 months, with a 20.2 months duration of institutionalization. Mean value of MNA was 20.1 3.5. 16.5% of patients had a BMI equal o lower than 21. After one year the intervention group showed higher levels of albumin (P=05), pre-albumin (P=05), iron (P=01), zinc (P=05), and beta-carotene (P=05) than the control group. The same response in BMI (P=05), MNA (P=05), and triceps skinfold (P=01). Mortality was lower (16% vs. 22.7%), without statistical significance, in the intervention group, as it was the number of infectious events (47% vs. 66% P=05), and the days in bed (7.5 2.1 vs. 17.3 5.6 P=05).

CONCLUSION

Nutritional supplements applied to a group of patients with AD living in nursing-homes can reduce morbidity and mortality after one year follow-up.

Authors+Show Affiliations

,

Hospital Clínico San Carlos, Geriatric Department, Martín Lagos S/N, 28040 Madrid, Spain. pgil@hcsc.insalud.es

, ,

Source

MeSH

Aged
Aged, 80 and over
Alzheimer Disease
Anthropometry
Blood Chemical Analysis
Dietary Supplements
Disease Progression
Female
Humans
Institutionalization
Male
Nutrition Assessment
Nutritional Status
Regression Analysis
Spain

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

12917745

Citation

Gil Gregorio, P, et al. "Dementia and Nutrition. Intervention Study in Institutionalized Patients With Alzheimer Disease." The Journal of Nutrition, Health & Aging, vol. 7, no. 5, 2003, pp. 304-8.
Gil Gregorio P, Ramirez Diaz SP, Ribera Casado JM, et al. Dementia and Nutrition. Intervention study in institutionalized patients with Alzheimer disease. J Nutr Health Aging. 2003;7(5):304-8.
Gil Gregorio, P., Ramirez Diaz, S. P., & Ribera Casado, J. M. (2003). Dementia and Nutrition. Intervention study in institutionalized patients with Alzheimer disease. The Journal of Nutrition, Health & Aging, 7(5), pp. 304-8.
Gil Gregorio P, et al. Dementia and Nutrition. Intervention Study in Institutionalized Patients With Alzheimer Disease. J Nutr Health Aging. 2003;7(5):304-8. PubMed PMID: 12917745.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dementia and Nutrition. Intervention study in institutionalized patients with Alzheimer disease. AU - Gil Gregorio,P, AU - Ramirez Diaz,S P, AU - Ribera Casado,J M, AU - ,, PY - 2003/8/15/pubmed PY - 2003/12/16/medline PY - 2003/8/15/entrez SP - 304 EP - 8 JF - The journal of nutrition, health & aging JO - J Nutr Health Aging VL - 7 IS - 5 N2 - OBJECTIVES: To know nutritional status of a group of institutionalized patients with moderate Alzheimer's Disease (AD), and to ascertain the effects of an intervention with nutritional supplements on morbidity and mortality after one year follow-up. PATIENTS AND METHODS: 99 patients (mean age: 86.5 years), 80 women, with a diagnosis of AD according with NINCDS/ADRDA criteria, were recruited from 8 nursing-homes. 25 were included in an intervention group and received a nutritional supplements along 12 months. Evolution was evaluated according to the Functional Assessment Staging Test (FAST). Patients with FAST levels 5-6 were included. General clinical variables as well as variables reflecting cognitive state and nutritional status: anthropometric, biochemical data and Mini Nutritional Assessment (MNA) were analysed. Statistical analysis was carry out with the SPSS 10.0 package. RESULTS: Mean time since diagnosis was 49 months, with a 20.2 months duration of institutionalization. Mean value of MNA was 20.1 3.5. 16.5% of patients had a BMI equal o lower than 21. After one year the intervention group showed higher levels of albumin (P=05), pre-albumin (P=05), iron (P=01), zinc (P=05), and beta-carotene (P=05) than the control group. The same response in BMI (P=05), MNA (P=05), and triceps skinfold (P=01). Mortality was lower (16% vs. 22.7%), without statistical significance, in the intervention group, as it was the number of infectious events (47% vs. 66% P=05), and the days in bed (7.5 2.1 vs. 17.3 5.6 P=05). CONCLUSION: Nutritional supplements applied to a group of patients with AD living in nursing-homes can reduce morbidity and mortality after one year follow-up. SN - 1279-7707 UR - https://www.unboundmedicine.com/medline/citation/12917745/Dementia_and_Nutrition__Intervention_study_in_institutionalized_patients_with_Alzheimer_disease_ L2 - http://www.diseaseinfosearch.org/result/349 DB - PRIME DP - Unbound Medicine ER -