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Improvement in walking speed in poststroke spastic hemiplegia after intrathecal baclofen therapy: a preliminary study.
Arch Phys Med Rehabil. 2003 Aug; 84(8):1194-9.AP

Abstract

OBJECTIVE

To explore whether intrathecal baclofen (ITB) therapy improves ambulation in stroke survivors.

DESIGN

Case series.

SETTING

Tertiary care center.

PARTICIPANTS

Ten adults with poststroke hemiparesis who were ambulatory at the time of pump implantation.

INTERVENTIONS

Implantation of ITB pump after inadequate control of spasticity with other interventions. Time from stroke onset to implantation averaged 28.6 months (range, 9-55mo).

MAIN OUTCOME MEASURES

Customary walking speed was measured from the time required to walk 50ft (15m) at a self-selected pace. Evaluators rated spastic hypertonia and functional mobility.

RESULTS

Statistically significant improvements occurred in walking speed, functional mobility ratings, and spasticity (P<.05) at a follow-up interval that averaged 8.9 months. Mean walking speed over 50ft improved from 36.6 to 52cm/s. Mean Modified Ashworth Scale scores in the muscles of the affected lower limb improved from 2.0 to 0.4. Normal muscle strength (5/5) was preserved in the unaffected limbs.

CONCLUSIONS

This preliminary study suggests that ITB therapy, in combination with physical therapy, may improve walking speed and functional mobility in ambulatory individuals with poststroke spastic hemiplegia.

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Authors+Show Affiliations

Francisco GE
Physical Medicine and Rehabilitation Alliance, Baylor College of Medicine and University of Texas-Houston Medical School, Houston, TX, USA. francg@tirr.tmc.edu
Boake C
No affiliation info available

MeSH

AdultAgedBaclofenFemaleHemiplegiaHumansInfusion Pumps, ImplantableInjections, SpinalMaleMiddle AgedMuscle Relaxants, CentralMuscle SpasticitySeverity of Illness IndexStrokeStroke RehabilitationTreatment OutcomeWalking

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article

Language

eng

PubMed ID

12917859

Citation

Francisco, Gerard E., and Corwin Boake. "Improvement in Walking Speed in Poststroke Spastic Hemiplegia After Intrathecal Baclofen Therapy: a Preliminary Study." Archives of Physical Medicine and Rehabilitation, vol. 84, no. 8, 2003, pp. 1194-9.
Francisco GE, Boake C. Improvement in walking speed in poststroke spastic hemiplegia after intrathecal baclofen therapy: a preliminary study. Arch Phys Med Rehabil. 2003;84(8):1194-9.
Francisco, G. E., & Boake, C. (2003). Improvement in walking speed in poststroke spastic hemiplegia after intrathecal baclofen therapy: a preliminary study. Archives of Physical Medicine and Rehabilitation, 84(8), 1194-9.
Francisco GE, Boake C. Improvement in Walking Speed in Poststroke Spastic Hemiplegia After Intrathecal Baclofen Therapy: a Preliminary Study. Arch Phys Med Rehabil. 2003;84(8):1194-9. PubMed PMID: 12917859.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Improvement in walking speed in poststroke spastic hemiplegia after intrathecal baclofen therapy: a preliminary study. AU - Francisco,Gerard E, AU - Boake,Corwin, PY - 2003/8/15/pubmed PY - 2003/9/10/medline PY - 2003/8/15/entrez SP - 1194 EP - 9 JF - Archives of physical medicine and rehabilitation JO - Arch Phys Med Rehabil VL - 84 IS - 8 N2 - OBJECTIVE: To explore whether intrathecal baclofen (ITB) therapy improves ambulation in stroke survivors. DESIGN: Case series. SETTING: Tertiary care center. PARTICIPANTS: Ten adults with poststroke hemiparesis who were ambulatory at the time of pump implantation. INTERVENTIONS: Implantation of ITB pump after inadequate control of spasticity with other interventions. Time from stroke onset to implantation averaged 28.6 months (range, 9-55mo). MAIN OUTCOME MEASURES: Customary walking speed was measured from the time required to walk 50ft (15m) at a self-selected pace. Evaluators rated spastic hypertonia and functional mobility. RESULTS: Statistically significant improvements occurred in walking speed, functional mobility ratings, and spasticity (P<.05) at a follow-up interval that averaged 8.9 months. Mean walking speed over 50ft improved from 36.6 to 52cm/s. Mean Modified Ashworth Scale scores in the muscles of the affected lower limb improved from 2.0 to 0.4. Normal muscle strength (5/5) was preserved in the unaffected limbs. CONCLUSIONS: This preliminary study suggests that ITB therapy, in combination with physical therapy, may improve walking speed and functional mobility in ambulatory individuals with poststroke spastic hemiplegia. SN - 0003-9993 UR - https://www.unboundmedicine.com/medline/citation/12917859/Improvement_in_walking_speed_in_poststroke_spastic_hemiplegia_after_intrathecal_baclofen_therapy:_a_preliminary_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0003-9993(03)00134-5 DB - PRIME DP - Unbound Medicine ER -