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[Coenzyme Q10: contractile dysfunction of the myocardial cell and metabolic therapy].
Minerva Cardioangiol 1992; 40(11):449-53MC

Abstract

Coenzyme Q10, a mitoquinone involved in mitochondrial energy synthesis and the removal of free radicals, may be lacking in a number of cardiac pathologies leading to reduced contractile activity. The administration of exogenous coenzyme Q10 may help to improve contractile activity. In order to assess this hypothesis 63 patients suffering from altered myocardial contractile function (29 dilated cardiopathies, 15 valvular cardiopathies, 19 ischemic cardiopathies) which presented a NYHA class above 2 were selected. The study was open and patients were subdivided into two groups, one of which received conventional therapy alone whereas the other also received exogenous coenzyme Q10. After 4 months of follow-up clinical (NYHA class, effort tolerance) and echocardiographical (ventricular diameter and contraction fraction %) parameters were evaluated. In those patients treated with coenzyme Q10 and suffering from dilated cardiomyopathy a significant reduction in the NYHA class and a marked improvement in echocardiographic parameters were observed at the end of this period. The variations observed in other groups of patients treated were less conspicuous and not always statistically significant. The results of this study confirm that the association of coenzyme Q10 and conventional therapy may lad to a marked improvement in contractile function and correlated clinical conditions.

Authors+Show Affiliations

U.O. Malattie Cardiovascolari, USL n. 16 Val d'Era, Pontedera, Pisa.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

ita

PubMed ID

1291925

Citation

Davini, A, et al. "[Coenzyme Q10: Contractile Dysfunction of the Myocardial Cell and Metabolic Therapy]." Minerva Cardioangiologica, vol. 40, no. 11, 1992, pp. 449-53.
Davini A, Cellerini F, Topi PL. [Coenzyme Q10: contractile dysfunction of the myocardial cell and metabolic therapy]. Minerva Cardioangiol. 1992;40(11):449-53.
Davini, A., Cellerini, F., & Topi, P. L. (1992). [Coenzyme Q10: contractile dysfunction of the myocardial cell and metabolic therapy]. Minerva Cardioangiologica, 40(11), pp. 449-53.
Davini A, Cellerini F, Topi PL. [Coenzyme Q10: Contractile Dysfunction of the Myocardial Cell and Metabolic Therapy]. Minerva Cardioangiol. 1992;40(11):449-53. PubMed PMID: 1291925.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Coenzyme Q10: contractile dysfunction of the myocardial cell and metabolic therapy]. AU - Davini,A, AU - Cellerini,F, AU - Topi,P L, PY - 1992/11/1/pubmed PY - 1992/11/1/medline PY - 1992/11/1/entrez SP - 449 EP - 53 JF - Minerva cardioangiologica JO - Minerva Cardioangiol VL - 40 IS - 11 N2 - Coenzyme Q10, a mitoquinone involved in mitochondrial energy synthesis and the removal of free radicals, may be lacking in a number of cardiac pathologies leading to reduced contractile activity. The administration of exogenous coenzyme Q10 may help to improve contractile activity. In order to assess this hypothesis 63 patients suffering from altered myocardial contractile function (29 dilated cardiopathies, 15 valvular cardiopathies, 19 ischemic cardiopathies) which presented a NYHA class above 2 were selected. The study was open and patients were subdivided into two groups, one of which received conventional therapy alone whereas the other also received exogenous coenzyme Q10. After 4 months of follow-up clinical (NYHA class, effort tolerance) and echocardiographical (ventricular diameter and contraction fraction %) parameters were evaluated. In those patients treated with coenzyme Q10 and suffering from dilated cardiomyopathy a significant reduction in the NYHA class and a marked improvement in echocardiographic parameters were observed at the end of this period. The variations observed in other groups of patients treated were less conspicuous and not always statistically significant. The results of this study confirm that the association of coenzyme Q10 and conventional therapy may lad to a marked improvement in contractile function and correlated clinical conditions. SN - 0026-4725 UR - https://www.unboundmedicine.com/medline/citation/1291925/[Coenzyme_Q10:_contractile_dysfunction_of_the_myocardial_cell_and_metabolic_therapy]_ L2 - https://medlineplus.gov/heartvalvediseases.html DB - PRIME DP - Unbound Medicine ER -