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[Value of glutamic acid decarboxylase autoantibody detection for early diagnosis of latent autoimmune diabetes in adults].
Di Yi Jun Yi Da Xue Xue Bao. 2003 Aug; 23(8):868-9.DY

Abstract

OBJECTIVE

To study the diagnostic values of detection of glutamic acid decarboxylase antibody (GAD-Ab) for latent autoimmune diabetes in adults (LADA).

METHOD

The clinical characteristics, body mass index (BMI), serum C-peptide levels, and HbAIC were compared between the 12 type 2 diabetic patients positive and 86 negative for GAD-Ab.

RESULTS

The mean age, BMI, fasting and postprandial 2 h C-peptide levels in GAD-Ab-positive group were lower than those of GAD-Ab-negative group. The frequency of insulin use and prevalence of ketosis were higher in GAD-Ab-positive group than in GAD-Ab-negative group.

CONCLUSIONS

The diagnosis of LADA can be established according to GAD-Ab-positivity, clinical characteristics and islet function. Patients with LADA should receive insulin therapy as early as possible to protect the residue islet B cells, reduce the occurrence of ketosis, and prevent diabetic complications of the eye, kidney and nerves.

Authors+Show Affiliations

Department of Geriatrics, First People's Hospital of Guangzhou, Guangzhou 510055, China.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

12919925

Citation

Huang, Yu-yu, et al. "[Value of Glutamic Acid Decarboxylase Autoantibody Detection for Early Diagnosis of Latent Autoimmune Diabetes in Adults]." Di 1 Jun Yi Da Xue Xue Bao = Academic Journal of the First Medical College of PLA, vol. 23, no. 8, 2003, pp. 868-9.
Huang YY, Huang P, Lou HL. [Value of glutamic acid decarboxylase autoantibody detection for early diagnosis of latent autoimmune diabetes in adults]. Di Yi Jun Yi Da Xue Xue Bao. 2003;23(8):868-9.
Huang, Y. Y., Huang, P., & Lou, H. L. (2003). [Value of glutamic acid decarboxylase autoantibody detection for early diagnosis of latent autoimmune diabetes in adults]. Di 1 Jun Yi Da Xue Xue Bao = Academic Journal of the First Medical College of PLA, 23(8), 868-9.
Huang YY, Huang P, Lou HL. [Value of Glutamic Acid Decarboxylase Autoantibody Detection for Early Diagnosis of Latent Autoimmune Diabetes in Adults]. Di Yi Jun Yi Da Xue Xue Bao. 2003;23(8):868-9. PubMed PMID: 12919925.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Value of glutamic acid decarboxylase autoantibody detection for early diagnosis of latent autoimmune diabetes in adults]. AU - Huang,Yu-yu, AU - Huang,Ping, AU - Lou,Hui-ling, PY - 2003/8/16/pubmed PY - 2004/1/30/medline PY - 2003/8/16/entrez SP - 868 EP - 9 JF - Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA JO - Di Yi Jun Yi Da Xue Xue Bao VL - 23 IS - 8 N2 - OBJECTIVE: To study the diagnostic values of detection of glutamic acid decarboxylase antibody (GAD-Ab) for latent autoimmune diabetes in adults (LADA). METHOD: The clinical characteristics, body mass index (BMI), serum C-peptide levels, and HbAIC were compared between the 12 type 2 diabetic patients positive and 86 negative for GAD-Ab. RESULTS: The mean age, BMI, fasting and postprandial 2 h C-peptide levels in GAD-Ab-positive group were lower than those of GAD-Ab-negative group. The frequency of insulin use and prevalence of ketosis were higher in GAD-Ab-positive group than in GAD-Ab-negative group. CONCLUSIONS: The diagnosis of LADA can be established according to GAD-Ab-positivity, clinical characteristics and islet function. Patients with LADA should receive insulin therapy as early as possible to protect the residue islet B cells, reduce the occurrence of ketosis, and prevent diabetic complications of the eye, kidney and nerves. SN - 1000-2588 UR - https://www.unboundmedicine.com/medline/citation/12919925/[Value_of_glutamic_acid_decarboxylase_autoantibody_detection_for_early_diagnosis_of_latent_autoimmune_diabetes_in_adults]_ L2 - http://www.diseaseinfosearch.org/result/2236 DB - PRIME DP - Unbound Medicine ER -
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