Tags

Type your tag names separated by a space and hit enter

Adipocytokines in anorexia nervosa: a review focusing on leptin and adiponectin.
Horm Metab Res. 2003 Jun; 35(6):337-42.HM

Abstract

Adipose tissue secretes a large number of physiologically active peptides that often share structural properties with cytokines, and are therefore collectively referred to as "adipocytokines". Some of these are almost exclusively secreted by adipose tissue. Leptin, adiponectin and resistin are specific fat-derived hormones that affect fuel homeostasis and insulin action, and may also be involved in hematopoiesis and immune functions. Anorexia nervosa is characterized by chronic self-starvation and severe weight loss, mainly at the expense of adipose tissue. Starvation-induced depletion of fat stores is accompanied by alterations of circulating adipocytokines. Plasma leptin and likely resistin levels are decreased in anorectic patients, while plasma adiponectin levels are increased. These alterations may have potential repercussions in the pathophysiology of anorexia nervosa. Thus, low leptin and high adiponectin may separately or in concert contribute to altered hematopoiesis and immunity, enhanced insulin sensitivity, neuroendocrine disturbances or osteopenia in anorexia nervosa.

Authors+Show Affiliations

Endocrinology and Metabolism Unit, Saint-Luc University Hospital, University of Louvain, Medical School, Brussels, Belgium. brichard@endo.ucl.ac.be.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

12920654

Citation

Brichard, S M., et al. "Adipocytokines in Anorexia Nervosa: a Review Focusing On Leptin and Adiponectin." Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, vol. 35, no. 6, 2003, pp. 337-42.
Brichard SM, Delporte ML, Lambert M. Adipocytokines in anorexia nervosa: a review focusing on leptin and adiponectin. Horm Metab Res. 2003;35(6):337-42.
Brichard, S. M., Delporte, M. L., & Lambert, M. (2003). Adipocytokines in anorexia nervosa: a review focusing on leptin and adiponectin. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, 35(6), 337-42.
Brichard SM, Delporte ML, Lambert M. Adipocytokines in Anorexia Nervosa: a Review Focusing On Leptin and Adiponectin. Horm Metab Res. 2003;35(6):337-42. PubMed PMID: 12920654.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adipocytokines in anorexia nervosa: a review focusing on leptin and adiponectin. AU - Brichard,S M, AU - Delporte,M L, AU - Lambert,M, PY - 2003/8/16/pubmed PY - 2004/5/22/medline PY - 2003/8/16/entrez SP - 337 EP - 42 JF - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme JO - Horm. Metab. Res. VL - 35 IS - 6 N2 - Adipose tissue secretes a large number of physiologically active peptides that often share structural properties with cytokines, and are therefore collectively referred to as "adipocytokines". Some of these are almost exclusively secreted by adipose tissue. Leptin, adiponectin and resistin are specific fat-derived hormones that affect fuel homeostasis and insulin action, and may also be involved in hematopoiesis and immune functions. Anorexia nervosa is characterized by chronic self-starvation and severe weight loss, mainly at the expense of adipose tissue. Starvation-induced depletion of fat stores is accompanied by alterations of circulating adipocytokines. Plasma leptin and likely resistin levels are decreased in anorectic patients, while plasma adiponectin levels are increased. These alterations may have potential repercussions in the pathophysiology of anorexia nervosa. Thus, low leptin and high adiponectin may separately or in concert contribute to altered hematopoiesis and immunity, enhanced insulin sensitivity, neuroendocrine disturbances or osteopenia in anorexia nervosa. SN - 0018-5043 UR - https://www.unboundmedicine.com/medline/citation/12920654/Adipocytokines_in_anorexia_nervosa:_a_review_focusing_on_leptin_and_adiponectin_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2003-41353 DB - PRIME DP - Unbound Medicine ER -