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Urinary and serum concentrations of seven phytoestrogens in a human reference population subset.
J Expo Anal Environ Epidemiol 2003; 13(4):276-82JE

Abstract

Diets rich in naturally occurring plant estrogens (phytoestrogens) are strongly associated with a decreased risk for cancer and heart disease in humans. Phytoestrogens have estrogenic and, in some cases, antiestrogenic and antiandrogenic properties, and may contribute to the protective effect of some diets. However, little information is available about the levels of these phytoestrogens in the general US population. Therefore, levels of phytoestrogens were determined in urine (N=199) and serum (N=208) samples taken from a nonrepresentative subset of adults who participated in NHANES III, 1988-1994. The phytoestrogens quantified were the lignans (enterolactone, enterodiol, matairesinol); the isoflavones (genistein, daidzein, equol, O-desmethylangolensin); and coumestrol (urine only). Phytoestrogens with the highest mean urinary levels were enterolactone (512 ng/ml), daidzein (317 ng/ml), and genistein (129 ng/ml). In serum, the concentrations were much less and the relative order was reversed, with genistein having the highest mean level (4.7 ng/ml), followed by daidzein (3.9 ng/ml) and enterolactone (3.6 ng/ml). Highly significant correlations of phytoestrogen levels in urine and serum samples from the same persons were observed for enterolactone, enterodiol, genistein, and daidzein. Determination of phytoestrogen concentrations in large study populations will give a better insight into the actual dietary exposure to these biologically active compounds in the US population.

Authors+Show Affiliations

National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA. LValentin@cdc.govNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

12923554

Citation

Valentín-Blasini, Liza, et al. "Urinary and Serum Concentrations of Seven Phytoestrogens in a Human Reference Population Subset." Journal of Exposure Analysis and Environmental Epidemiology, vol. 13, no. 4, 2003, pp. 276-82.
Valentín-Blasini L, Blount BC, Caudill SP, et al. Urinary and serum concentrations of seven phytoestrogens in a human reference population subset. J Expo Anal Environ Epidemiol. 2003;13(4):276-82.
Valentín-Blasini, L., Blount, B. C., Caudill, S. P., & Needham, L. L. (2003). Urinary and serum concentrations of seven phytoestrogens in a human reference population subset. Journal of Exposure Analysis and Environmental Epidemiology, 13(4), pp. 276-82.
Valentín-Blasini L, et al. Urinary and Serum Concentrations of Seven Phytoestrogens in a Human Reference Population Subset. J Expo Anal Environ Epidemiol. 2003;13(4):276-82. PubMed PMID: 12923554.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Urinary and serum concentrations of seven phytoestrogens in a human reference population subset. AU - Valentín-Blasini,Liza, AU - Blount,Benjamin C, AU - Caudill,Samuel P, AU - Needham,Larry L, PY - 2003/8/19/pubmed PY - 2003/12/12/medline PY - 2003/8/19/entrez SP - 276 EP - 82 JF - Journal of exposure analysis and environmental epidemiology JO - J Expo Anal Environ Epidemiol VL - 13 IS - 4 N2 - Diets rich in naturally occurring plant estrogens (phytoestrogens) are strongly associated with a decreased risk for cancer and heart disease in humans. Phytoestrogens have estrogenic and, in some cases, antiestrogenic and antiandrogenic properties, and may contribute to the protective effect of some diets. However, little information is available about the levels of these phytoestrogens in the general US population. Therefore, levels of phytoestrogens were determined in urine (N=199) and serum (N=208) samples taken from a nonrepresentative subset of adults who participated in NHANES III, 1988-1994. The phytoestrogens quantified were the lignans (enterolactone, enterodiol, matairesinol); the isoflavones (genistein, daidzein, equol, O-desmethylangolensin); and coumestrol (urine only). Phytoestrogens with the highest mean urinary levels were enterolactone (512 ng/ml), daidzein (317 ng/ml), and genistein (129 ng/ml). In serum, the concentrations were much less and the relative order was reversed, with genistein having the highest mean level (4.7 ng/ml), followed by daidzein (3.9 ng/ml) and enterolactone (3.6 ng/ml). Highly significant correlations of phytoestrogen levels in urine and serum samples from the same persons were observed for enterolactone, enterodiol, genistein, and daidzein. Determination of phytoestrogen concentrations in large study populations will give a better insight into the actual dietary exposure to these biologically active compounds in the US population. SN - 1053-4245 UR - https://www.unboundmedicine.com/medline/citation/12923554/Urinary_and_serum_concentrations_of_seven_phytoestrogens_in_a_human_reference_population_subset_ L2 - http://dx.doi.org/10.1038/sj.jea.7500278 DB - PRIME DP - Unbound Medicine ER -