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[The dry binders, Vivapur 102, Vivapur 12 and the effect of magnesium stearate on the strength of tablets containing these substances].
Ceska Slov Farm. 2003 Jul; 52(4):176-80.CS

Abstract

Vivapur is microcrystalline cellulose manufactured by the German firm J. Rettenmeier & Söhne GmbH + Co. The types Vivapur 102 and 12 enjoy priority use as dry binders for direct tablet compression. The present paper evaluates tensile strength of tablets made from these substances and the effect of an addition of the lubricant magnesium stearate in connection with its concentration and the conditions of the process of mixing, particularly the period and intensity of mixing. The tested concentrations of stearate were 0.4 and 0.8%, the tested periods of mixing being 2.5, 5, 10, and 20 minutes, intensities of mixing 17 and 34 rot./min. Sensitivity of dry binders to added stearate was evaluated by means of the LSR (lubricant sensitivity ratio) values. The results demonstrated higher sensitivity to an addition of the lubricant in Vivapur 12 than in Vivapur 102. In the first part of the paper focused on the effect of stearate concentration on tensile strength of tablets, Vivapur 102 was also compared with Avicel PH-102. Tablets from Vivapur 102 alone were stronger than those from Avicel PH-102. A concentration of stearate of 0.8% decreased the binding capacity of Vivapur 102 more than that of Avicel PH-102. With a prolonged period of mixing and increased intensity of mixing with stearate, tensile strength of tablets from both Vivapur types was decresed, and a prolonged period of mixing exerted a more marked effect on Vivapur 12 and increased intensity of mixing, on Vivapur 102.

Authors+Show Affiliations

Muzíková J
Katedra farmaceutické technologie Farmaceutické fakulty Univerzity Karlovy, Hradec Králové. muzikova@faf.cuni.cz
Horácek J
No affiliation info available

MeSH

CelluloseChemistry, PharmaceuticalPharmaceutic AidsStearic AcidsTablets

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

cze

PubMed ID

12924068

Citation

Muzíková, J, and J Horácek. "[The Dry Binders, Vivapur 102, Vivapur 12 and the Effect of Magnesium Stearate On the Strength of Tablets Containing These Substances]." Ceska a Slovenska Farmacie : Casopis Ceske Farmaceuticke Spolecnosti a Slovenske Farmaceuticke Spolecnosti, vol. 52, no. 4, 2003, pp. 176-80.
Muzíková J, Horácek J. [The dry binders, Vivapur 102, Vivapur 12 and the effect of magnesium stearate on the strength of tablets containing these substances]. Ceska Slov Farm. 2003;52(4):176-80.
Muzíková, J., & Horácek, J. (2003). [The dry binders, Vivapur 102, Vivapur 12 and the effect of magnesium stearate on the strength of tablets containing these substances]. Ceska a Slovenska Farmacie : Casopis Ceske Farmaceuticke Spolecnosti a Slovenske Farmaceuticke Spolecnosti, 52(4), 176-80.
Muzíková J, Horácek J. [The Dry Binders, Vivapur 102, Vivapur 12 and the Effect of Magnesium Stearate On the Strength of Tablets Containing These Substances]. Ceska Slov Farm. 2003;52(4):176-80. PubMed PMID: 12924068.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The dry binders, Vivapur 102, Vivapur 12 and the effect of magnesium stearate on the strength of tablets containing these substances]. AU - Muzíková,J, AU - Horácek,J, PY - 2003/8/20/pubmed PY - 2003/9/27/medline PY - 2003/8/20/entrez SP - 176 EP - 80 JF - Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti JO - Ceska Slov Farm VL - 52 IS - 4 N2 - Vivapur is microcrystalline cellulose manufactured by the German firm J. Rettenmeier & Söhne GmbH + Co. The types Vivapur 102 and 12 enjoy priority use as dry binders for direct tablet compression. The present paper evaluates tensile strength of tablets made from these substances and the effect of an addition of the lubricant magnesium stearate in connection with its concentration and the conditions of the process of mixing, particularly the period and intensity of mixing. The tested concentrations of stearate were 0.4 and 0.8%, the tested periods of mixing being 2.5, 5, 10, and 20 minutes, intensities of mixing 17 and 34 rot./min. Sensitivity of dry binders to added stearate was evaluated by means of the LSR (lubricant sensitivity ratio) values. The results demonstrated higher sensitivity to an addition of the lubricant in Vivapur 12 than in Vivapur 102. In the first part of the paper focused on the effect of stearate concentration on tensile strength of tablets, Vivapur 102 was also compared with Avicel PH-102. Tablets from Vivapur 102 alone were stronger than those from Avicel PH-102. A concentration of stearate of 0.8% decreased the binding capacity of Vivapur 102 more than that of Avicel PH-102. With a prolonged period of mixing and increased intensity of mixing with stearate, tensile strength of tablets from both Vivapur types was decresed, and a prolonged period of mixing exerted a more marked effect on Vivapur 12 and increased intensity of mixing, on Vivapur 102. SN - 1210-7816 UR - https://www.unboundmedicine.com/medline/citation/12924068/[The_dry_binders_Vivapur_102_Vivapur_12_and_the_effect_of_magnesium_stearate_on_the_strength_of_tablets_containing_these_substances]_ DB - PRIME DP - Unbound Medicine ER -