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The role of postoperative adjuvant radiation therapy in the treatment of mucosal melanomas of the head and neck region.
Arch Otolaryngol Head Neck Surg. 2003 Aug; 129(8):864-8.AO

Abstract

BACKGROUND

Mucosal melanoma of the head and neck is uncommon, and has a poor prognosis due to locoregional and distant failure. The optimal treatment paradigm for patients with this disease has yet to be determined.

OBJECTIVE

To compare the outcomes of patients treated with various commonly used protocols for mucosal melanoma of the head and neck.

DESIGN

Retrospective study.

SETTING

Academic tertiary referral center.

PATIENTS

The medical records of 48 consecutive patients treated at a single institution from January 1, 1985, to December 31, 1998, were reviewed.

INTERVENTIONS

Patients were treated with surgery alone, surgery and adjuvant radiotherapy, or surgery and biochemotherapy, with or without adjuvant radiotherapy.

MAIN OUTCOME MEASURES

The outcomes of disease recurrence and survival were correlated with the treatment received.

RESULTS

Twenty patients received surgical treatment alone; in 9 patients (45%), this treatment failed locoregionally, and 10 (50%) of the patients developed distant metastases. The 5-year survival rate was 45% (9 of 20 patients). Twenty-four patients received postoperative adjuvant radiotherapy; in 4 patients (17%), this treatment failed locally, and 11 (46%) of the patients developed distant metastases. The 5-year survival rate was 29% (7 of 24 patients).

CONCLUSION

The addition of radiotherapy tended to decrease the rate of local failure (P =.13), but did not significantly improve survival (P =.73), because of the high rate of distant metastatic disease.

Authors+Show Affiliations

Department of Otolaryngology-Head and Neck Surgery, University of Colorado Health Sciences Center, Denver 80262, USA. jonathan.owens@uchsc.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12925346

Citation

Owens, Jonathan M., et al. "The Role of Postoperative Adjuvant Radiation Therapy in the Treatment of Mucosal Melanomas of the Head and Neck Region." Archives of Otolaryngology--head & Neck Surgery, vol. 129, no. 8, 2003, pp. 864-8.
Owens JM, Roberts DB, Myers JN. The role of postoperative adjuvant radiation therapy in the treatment of mucosal melanomas of the head and neck region. Arch Otolaryngol Head Neck Surg. 2003;129(8):864-8.
Owens, J. M., Roberts, D. B., & Myers, J. N. (2003). The role of postoperative adjuvant radiation therapy in the treatment of mucosal melanomas of the head and neck region. Archives of Otolaryngology--head & Neck Surgery, 129(8), 864-8.
Owens JM, Roberts DB, Myers JN. The Role of Postoperative Adjuvant Radiation Therapy in the Treatment of Mucosal Melanomas of the Head and Neck Region. Arch Otolaryngol Head Neck Surg. 2003;129(8):864-8. PubMed PMID: 12925346.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of postoperative adjuvant radiation therapy in the treatment of mucosal melanomas of the head and neck region. AU - Owens,Jonathan M, AU - Roberts,Dianna B, AU - Myers,Jeffrey N, PY - 2003/8/20/pubmed PY - 2003/10/3/medline PY - 2003/8/20/entrez SP - 864 EP - 8 JF - Archives of otolaryngology--head & neck surgery JO - Arch Otolaryngol Head Neck Surg VL - 129 IS - 8 N2 - BACKGROUND: Mucosal melanoma of the head and neck is uncommon, and has a poor prognosis due to locoregional and distant failure. The optimal treatment paradigm for patients with this disease has yet to be determined. OBJECTIVE: To compare the outcomes of patients treated with various commonly used protocols for mucosal melanoma of the head and neck. DESIGN: Retrospective study. SETTING: Academic tertiary referral center. PATIENTS: The medical records of 48 consecutive patients treated at a single institution from January 1, 1985, to December 31, 1998, were reviewed. INTERVENTIONS: Patients were treated with surgery alone, surgery and adjuvant radiotherapy, or surgery and biochemotherapy, with or without adjuvant radiotherapy. MAIN OUTCOME MEASURES: The outcomes of disease recurrence and survival were correlated with the treatment received. RESULTS: Twenty patients received surgical treatment alone; in 9 patients (45%), this treatment failed locoregionally, and 10 (50%) of the patients developed distant metastases. The 5-year survival rate was 45% (9 of 20 patients). Twenty-four patients received postoperative adjuvant radiotherapy; in 4 patients (17%), this treatment failed locally, and 11 (46%) of the patients developed distant metastases. The 5-year survival rate was 29% (7 of 24 patients). CONCLUSION: The addition of radiotherapy tended to decrease the rate of local failure (P =.13), but did not significantly improve survival (P =.73), because of the high rate of distant metastatic disease. SN - 0886-4470 UR - https://www.unboundmedicine.com/medline/citation/12925346/The_role_of_postoperative_adjuvant_radiation_therapy_in_the_treatment_of_mucosal_melanomas_of_the_head_and_neck_region_ L2 - https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/vol/129/pg/864 DB - PRIME DP - Unbound Medicine ER -