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Breast hamartoma: fine-needle aspiration cytologic finding.
Cancer. 2003 Aug 25; 99(4):255-8.C

Abstract

BACKGROUND

Breast hamartoma is an unusual, well-circumscribed, tumor-like mass entering into the differential diagnosis of benign breast disease. To the authors' knowledge, the cytology of these lesions has not been well described. Although fine-needle aspiration is a well established procedure for the detection of breast carcinoma, its utility in classifying benign breast disease is less clear.

METHODS

Fine-needle aspirates from eight patients with histologically proven hamartomas were reviewed. None of the cases had a preoperative fine-needle aspiration diagnosis of hamartoma. Cytologic characteristics were retrospectively evaluated in a semiquantitative manner and compared with the histologic findings.

RESULTS

The aspirates were moderately cellular and contained sheets of both bland ductal cells and lobular units. Adipose tissue was present in varying amounts. Bipolar stromal nuclei were readily apparent, whereas intact stromal fragments were less prominent. Cytologic atypia was uniformly absent.

CONCLUSIONS

The cytology of breast hamartomas shows considerable overlap with other benign breast disease and is unlikely to be interpreted as malignant. The findings of intact lobular units and a relative paucity of stroma in an aspirate from a well circumscribed breast lesion may suggest the diagnosis of hamartoma.

Authors+Show Affiliations

Department of Pathology, Assaf Harofeh Medical Center, Zerifin, Tel-Aviv University, Tel-Aviv, Israel. herbert12@37.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12925988

Citation

Herbert, Mehrdad, et al. "Breast Hamartoma: Fine-needle Aspiration Cytologic Finding." Cancer, vol. 99, no. 4, 2003, pp. 255-8.
Herbert M, Schvimer M, Zehavi S, et al. Breast hamartoma: fine-needle aspiration cytologic finding. Cancer. 2003;99(4):255-8.
Herbert, M., Schvimer, M., Zehavi, S., Mendlovic, S., Karni, T., Pappo, I., & Sandbank, J. (2003). Breast hamartoma: fine-needle aspiration cytologic finding. Cancer, 99(4), 255-8.
Herbert M, et al. Breast Hamartoma: Fine-needle Aspiration Cytologic Finding. Cancer. 2003 Aug 25;99(4):255-8. PubMed PMID: 12925988.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Breast hamartoma: fine-needle aspiration cytologic finding. AU - Herbert,Mehrdad, AU - Schvimer,Michael, AU - Zehavi,Sergei, AU - Mendlovic,Sonia, AU - Karni,Tami, AU - Pappo,Itzhak, AU - Sandbank,Judith, PY - 2003/8/20/pubmed PY - 2003/9/5/medline PY - 2003/8/20/entrez SP - 255 EP - 8 JF - Cancer JO - Cancer VL - 99 IS - 4 N2 - BACKGROUND: Breast hamartoma is an unusual, well-circumscribed, tumor-like mass entering into the differential diagnosis of benign breast disease. To the authors' knowledge, the cytology of these lesions has not been well described. Although fine-needle aspiration is a well established procedure for the detection of breast carcinoma, its utility in classifying benign breast disease is less clear. METHODS: Fine-needle aspirates from eight patients with histologically proven hamartomas were reviewed. None of the cases had a preoperative fine-needle aspiration diagnosis of hamartoma. Cytologic characteristics were retrospectively evaluated in a semiquantitative manner and compared with the histologic findings. RESULTS: The aspirates were moderately cellular and contained sheets of both bland ductal cells and lobular units. Adipose tissue was present in varying amounts. Bipolar stromal nuclei were readily apparent, whereas intact stromal fragments were less prominent. Cytologic atypia was uniformly absent. CONCLUSIONS: The cytology of breast hamartomas shows considerable overlap with other benign breast disease and is unlikely to be interpreted as malignant. The findings of intact lobular units and a relative paucity of stroma in an aspirate from a well circumscribed breast lesion may suggest the diagnosis of hamartoma. SN - 0008-543X UR - https://www.unboundmedicine.com/medline/citation/12925988/Breast_hamartoma:_fine_needle_aspiration_cytologic_finding_ L2 - https://doi.org/10.1002/cncr.11419 DB - PRIME DP - Unbound Medicine ER -