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Methylenetetrahydrofolate reductase and angiotensin converting enzyme gene polymorphisms in two genetically and diagnostically distinct cohort of Alzheimer patients.
Neurobiol Aging 2003; 24(7):933-9NA

Abstract

The role of methylenetetrahydrofolate reductase (MTHFR) and angiotensin converting enzyme (ACE) gene polymorphisms as risk factors for the occurrence of Alzheimer's disease (AD) is still controversial. In this study, we investigated the common MTHFR C677-->T and ACE insertion/deletion (I/D) gene polymorphisms as risk factors for AD in two genetically and diagnostically distinct cohort of Alzheimer's patients. We analyzed a neuropathologically confirmed American cohort of 124 AD patients and 97 elderly controls, and a clinically diagnosed Italian cohort of 126 probable AD cases, 106 elderly controls, and a community-based sample of 1232 subjects aged under 65 years. No difference was found in polymorphism distribution between cases and controls in both study cohorts. We also tested a possible association between the polymorphisms investigated. No interaction was found between the MTHFR and ACE alleles. Moreover, no association was found for the ACE and MTHFR polymorphisms with age at onset, disease duration and MMSE score at observation. Thus, in our study, MTHFR C677-->T and ACE I/D polymorphisms do not appear to confer an added risk for AD.

Authors+Show Affiliations

Laboratory of Molecular Pathology and Gene Therapy, IRCCS H Casa Sollievo della Sofferenza, Opera di Padre Pio da Pietrelcina, San Giovanni Rotondo (FG), Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12928053

Citation

Seripa, Davide, et al. "Methylenetetrahydrofolate Reductase and Angiotensin Converting Enzyme Gene Polymorphisms in Two Genetically and Diagnostically Distinct Cohort of Alzheimer Patients." Neurobiology of Aging, vol. 24, no. 7, 2003, pp. 933-9.
Seripa D, Forno GD, Matera MG, et al. Methylenetetrahydrofolate reductase and angiotensin converting enzyme gene polymorphisms in two genetically and diagnostically distinct cohort of Alzheimer patients. Neurobiol Aging. 2003;24(7):933-9.
Seripa, D., Forno, G. D., Matera, M. G., Gravina, C., Margaglione, M., Palermo, M. T., ... Fazio, V. M. (2003). Methylenetetrahydrofolate reductase and angiotensin converting enzyme gene polymorphisms in two genetically and diagnostically distinct cohort of Alzheimer patients. Neurobiology of Aging, 24(7), pp. 933-9.
Seripa D, et al. Methylenetetrahydrofolate Reductase and Angiotensin Converting Enzyme Gene Polymorphisms in Two Genetically and Diagnostically Distinct Cohort of Alzheimer Patients. Neurobiol Aging. 2003;24(7):933-9. PubMed PMID: 12928053.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Methylenetetrahydrofolate reductase and angiotensin converting enzyme gene polymorphisms in two genetically and diagnostically distinct cohort of Alzheimer patients. AU - Seripa,Davide, AU - Forno,Gloria Dal, AU - Matera,Maria G, AU - Gravina,Carolina, AU - Margaglione,Maurizio, AU - Palermo,Mark T, AU - Wekstein,David R, AU - Antuono,Piero, AU - Davis,Daron G, AU - Daniele,Antonio, AU - Masullo,Carlo, AU - Bizzarro,Alessandra, AU - Gennarelli,Massimo, AU - Fazio,Vito M, PY - 2003/8/21/pubmed PY - 2003/12/11/medline PY - 2003/8/21/entrez SP - 933 EP - 9 JF - Neurobiology of aging JO - Neurobiol. Aging VL - 24 IS - 7 N2 - The role of methylenetetrahydrofolate reductase (MTHFR) and angiotensin converting enzyme (ACE) gene polymorphisms as risk factors for the occurrence of Alzheimer's disease (AD) is still controversial. In this study, we investigated the common MTHFR C677-->T and ACE insertion/deletion (I/D) gene polymorphisms as risk factors for AD in two genetically and diagnostically distinct cohort of Alzheimer's patients. We analyzed a neuropathologically confirmed American cohort of 124 AD patients and 97 elderly controls, and a clinically diagnosed Italian cohort of 126 probable AD cases, 106 elderly controls, and a community-based sample of 1232 subjects aged under 65 years. No difference was found in polymorphism distribution between cases and controls in both study cohorts. We also tested a possible association between the polymorphisms investigated. No interaction was found between the MTHFR and ACE alleles. Moreover, no association was found for the ACE and MTHFR polymorphisms with age at onset, disease duration and MMSE score at observation. Thus, in our study, MTHFR C677-->T and ACE I/D polymorphisms do not appear to confer an added risk for AD. SN - 0197-4580 UR - https://www.unboundmedicine.com/medline/citation/12928053/Methylenetetrahydrofolate_reductase_and_angiotensin_converting_enzyme_gene_polymorphisms_in_two_genetically_and_diagnostically_distinct_cohort_of_Alzheimer_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S019745800300040X DB - PRIME DP - Unbound Medicine ER -