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[Sporadic and hereditary colorectal cancer. Pathogenetically different with different therapeutic indications].
Chirurg. 2003 Aug; 74(8):717-25.C

Abstract

In recent years, there have been major advances regarding the understanding of the pathogenesis of sporadic and hereditary colorectal cancer on the basis of molecular research. The clinical implications of this knowledge differ for the sporadic and hereditary forms. In sporadic colorectal cancer, gene mutations occur in colorectal cells but not as germline mutations. Even though molecular data currently do not influence the clinical management of this form of colorectal cancer, promising molecular approaches exist for the assessment of prognosis, early detection, prevention, and therapy. Germline mutations are the cause of hereditary colorectal cancers, in which molecular methods have a major impact on diagnosis and therapy. Prophylactic surgery is accepted for patients with familial adenomatous polyposis (FAP), but not for patients with hereditary non-polyposis colorectal cancer (HNPCC), the second main form of hereditary colorectal cancer. Further studies will have to clarity this issue.

Authors+Show Affiliations

Abteilung für Allgemein-,Visceral- und Unfallchirurgie, Chirurgische Universitätsklinik, Heidelberg. juergen_weitz@med.uniheidelberg.deNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
English Abstract
Journal Article
Review

Language

ger

PubMed ID

12928792

Citation

Weitz, J, et al. "[Sporadic and Hereditary Colorectal Cancer. Pathogenetically Different With Different Therapeutic Indications]." Der Chirurg; Zeitschrift Fur Alle Gebiete Der Operativen Medizen, vol. 74, no. 8, 2003, pp. 717-25.
Weitz J, Knaebel HP, Büchler MW. [Sporadic and hereditary colorectal cancer. Pathogenetically different with different therapeutic indications]. Chirurg. 2003;74(8):717-25.
Weitz, J., Knaebel, H. P., & Büchler, M. W. (2003). [Sporadic and hereditary colorectal cancer. Pathogenetically different with different therapeutic indications]. Der Chirurg; Zeitschrift Fur Alle Gebiete Der Operativen Medizen, 74(8), 717-25.
Weitz J, Knaebel HP, Büchler MW. [Sporadic and Hereditary Colorectal Cancer. Pathogenetically Different With Different Therapeutic Indications]. Chirurg. 2003;74(8):717-25. PubMed PMID: 12928792.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Sporadic and hereditary colorectal cancer. Pathogenetically different with different therapeutic indications]. AU - Weitz,J, AU - Knaebel,H-P, AU - Büchler,M W, PY - 2003/8/21/pubmed PY - 2004/1/13/medline PY - 2003/8/21/entrez SP - 717 EP - 25 JF - Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen JO - Chirurg VL - 74 IS - 8 N2 - In recent years, there have been major advances regarding the understanding of the pathogenesis of sporadic and hereditary colorectal cancer on the basis of molecular research. The clinical implications of this knowledge differ for the sporadic and hereditary forms. In sporadic colorectal cancer, gene mutations occur in colorectal cells but not as germline mutations. Even though molecular data currently do not influence the clinical management of this form of colorectal cancer, promising molecular approaches exist for the assessment of prognosis, early detection, prevention, and therapy. Germline mutations are the cause of hereditary colorectal cancers, in which molecular methods have a major impact on diagnosis and therapy. Prophylactic surgery is accepted for patients with familial adenomatous polyposis (FAP), but not for patients with hereditary non-polyposis colorectal cancer (HNPCC), the second main form of hereditary colorectal cancer. Further studies will have to clarity this issue. SN - 0009-4722 UR - https://www.unboundmedicine.com/medline/citation/12928792/[Sporadic_and_hereditary_colorectal_cancer__Pathogenetically_different_with_different_therapeutic_indications]_ L2 - https://dx.doi.org/10.1007/s00104-003-0702-y DB - PRIME DP - Unbound Medicine ER -