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Fracture prediction from bone mineral density in Japanese men and women.
J Bone Miner Res 2003; 18(8):1547-53JB

Abstract

In a cohort of 2356 Japanese elderly, after adjusting for age and prevalent vertebral fracture, baseline BMD predicted the risk of spine and hip fracture with similar RR to that obtained from previous reports in whites. The RR per SD decrease in BMD for fracture declined with age.

INTRODUCTION

Low bone mineral density (BMD) is one of the most important predictors of a future fracture. However, we are not aware of any reports among Japanese in Japan.

MATERIALS AND METHODS

We examined the association of BMD with risk of fracture of the spine or hip among a cohort of 2356 men and women aged 47-95 years, who were followed up by biennial health examinations. Follow-up averaged 4 years after baseline measurements of BMD that were taken with the use of DXA. Vertebral fracture was assessed using semiquantitative methods, and the diagnosis of hip fracture was based on medical records. Poisson and Cox regression analysis were used.

RESULTS

The incidence was twice as high in women as in men, after adjusting for age. After adjusting for baseline BMD and prevalent vertebral fracture, however, the gender difference was no longer significant. Age, baseline BMD of spine and femoral neck, and prior vertebral fracture predicted vertebral fracture and hip fracture. Loss of absolute BMD of the femoral neck predicted spine fracture, after adjusting for baseline BMD; rates of change in percent BMD, weight, height, body mass index, and age at menopause did not. The predictive value of baseline BMD for vertebral fracture risk was similar in men and women. The relative risk (RR) for vertebral fracture and hip fracture per SD decrease in BMD declined with age, after adjustment for prevalent vertebral fractures.

CONCLUSIONS

Baseline BMD, loss of femoral neck BMD, and prior vertebral fracture predict the risk of spine and hip fracture in Japanese with similar RR to that obtained from previous reports in whites. The RR per SD decrease in BMD for fracture declined with age, suggesting that factors other than BMD might play a greater role in the elderly.

Authors+Show Affiliations

Department of Clinical Studies, Radiation Effects Research Foundation, Hiroshima, Japan. fujiwara@rerf.or.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

12929946

Citation

Fujiwara, Saeko, et al. "Fracture Prediction From Bone Mineral Density in Japanese Men and Women." Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, vol. 18, no. 8, 2003, pp. 1547-53.
Fujiwara S, Kasagi F, Masunari N, et al. Fracture prediction from bone mineral density in Japanese men and women. J Bone Miner Res. 2003;18(8):1547-53.
Fujiwara, S., Kasagi, F., Masunari, N., Naito, K., Suzuki, G., & Fukunaga, M. (2003). Fracture prediction from bone mineral density in Japanese men and women. Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, 18(8), pp. 1547-53.
Fujiwara S, et al. Fracture Prediction From Bone Mineral Density in Japanese Men and Women. J Bone Miner Res. 2003;18(8):1547-53. PubMed PMID: 12929946.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fracture prediction from bone mineral density in Japanese men and women. AU - Fujiwara,Saeko, AU - Kasagi,Fumiyoshi, AU - Masunari,Naomi, AU - Naito,Kumiko, AU - Suzuki,Gen, AU - Fukunaga,Masao, PY - 2003/8/22/pubmed PY - 2004/4/2/medline PY - 2003/8/22/entrez SP - 1547 EP - 53 JF - Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research JO - J. Bone Miner. Res. VL - 18 IS - 8 N2 - UNLABELLED: In a cohort of 2356 Japanese elderly, after adjusting for age and prevalent vertebral fracture, baseline BMD predicted the risk of spine and hip fracture with similar RR to that obtained from previous reports in whites. The RR per SD decrease in BMD for fracture declined with age. INTRODUCTION: Low bone mineral density (BMD) is one of the most important predictors of a future fracture. However, we are not aware of any reports among Japanese in Japan. MATERIALS AND METHODS: We examined the association of BMD with risk of fracture of the spine or hip among a cohort of 2356 men and women aged 47-95 years, who were followed up by biennial health examinations. Follow-up averaged 4 years after baseline measurements of BMD that were taken with the use of DXA. Vertebral fracture was assessed using semiquantitative methods, and the diagnosis of hip fracture was based on medical records. Poisson and Cox regression analysis were used. RESULTS: The incidence was twice as high in women as in men, after adjusting for age. After adjusting for baseline BMD and prevalent vertebral fracture, however, the gender difference was no longer significant. Age, baseline BMD of spine and femoral neck, and prior vertebral fracture predicted vertebral fracture and hip fracture. Loss of absolute BMD of the femoral neck predicted spine fracture, after adjusting for baseline BMD; rates of change in percent BMD, weight, height, body mass index, and age at menopause did not. The predictive value of baseline BMD for vertebral fracture risk was similar in men and women. The relative risk (RR) for vertebral fracture and hip fracture per SD decrease in BMD declined with age, after adjustment for prevalent vertebral fractures. CONCLUSIONS: Baseline BMD, loss of femoral neck BMD, and prior vertebral fracture predict the risk of spine and hip fracture in Japanese with similar RR to that obtained from previous reports in whites. The RR per SD decrease in BMD for fracture declined with age, suggesting that factors other than BMD might play a greater role in the elderly. SN - 0884-0431 UR - https://www.unboundmedicine.com/medline/citation/12929946/Fracture_prediction_from_bone_mineral_density_in_Japanese_men_and_women_ L2 - https://doi.org/10.1359/jbmr.2003.18.8.1547 DB - PRIME DP - Unbound Medicine ER -