Tags

Type your tag names separated by a space and hit enter

The endocannabinoid system, anandamide and the regulation of mammalian cell apoptosis.
Cell Death Differ 2003; 10(9):946-55CD

Abstract

Endocannabinoids are a new class of lipid mediators, which include amides, esters and ethers of long-chain polyunsaturated fatty acids. Anandamide (N-arachidonoylethanolamine; AEA) and 2-arachidonoylglycerol (2-AG) are the main endogenous agonists of cannabinoid receptors able to mimic several pharmacological effects of Delta-9-tetrahydrocannabinol, the active principle of Cannabis sativa preparations like hashish and marijuana. The pathways leading to the synthesis and release of AEA and 2-AG from neuronal and non-neuronal cells are still rather uncertain. Instead, it is known that the activity of AEA is limited by cellular uptake through a specific membrane transporter, followed by intracellular degradation by a fatty acid amide hydrolase. Together with AEA and congeners these proteins form the 'endocannabinoid system'. Here, the involvement of AEA in apoptosis and the underlying signal transduction pathways will be reviewed, along with the metabolic routes and the molecular targets of this endocannabinoid. Also, recent findings on the apoptotic potential of AEA for neuronal cell differentiation and brain development will be discussed.

Authors+Show Affiliations

Department of Biomedical Sciences, University of Teramo, Teramo, Italy. Maccarrone@vet.unite.itNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

12934069

Citation

Maccarrone, M, and A Finazzi-Agró. "The Endocannabinoid System, Anandamide and the Regulation of Mammalian Cell Apoptosis." Cell Death and Differentiation, vol. 10, no. 9, 2003, pp. 946-55.
Maccarrone M, Finazzi-Agró A. The endocannabinoid system, anandamide and the regulation of mammalian cell apoptosis. Cell Death Differ. 2003;10(9):946-55.
Maccarrone, M., & Finazzi-Agró, A. (2003). The endocannabinoid system, anandamide and the regulation of mammalian cell apoptosis. Cell Death and Differentiation, 10(9), pp. 946-55.
Maccarrone M, Finazzi-Agró A. The Endocannabinoid System, Anandamide and the Regulation of Mammalian Cell Apoptosis. Cell Death Differ. 2003;10(9):946-55. PubMed PMID: 12934069.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The endocannabinoid system, anandamide and the regulation of mammalian cell apoptosis. AU - Maccarrone,M, AU - Finazzi-Agró,A, PY - 2003/8/23/pubmed PY - 2004/4/17/medline PY - 2003/8/23/entrez SP - 946 EP - 55 JF - Cell death and differentiation JO - Cell Death Differ. VL - 10 IS - 9 N2 - Endocannabinoids are a new class of lipid mediators, which include amides, esters and ethers of long-chain polyunsaturated fatty acids. Anandamide (N-arachidonoylethanolamine; AEA) and 2-arachidonoylglycerol (2-AG) are the main endogenous agonists of cannabinoid receptors able to mimic several pharmacological effects of Delta-9-tetrahydrocannabinol, the active principle of Cannabis sativa preparations like hashish and marijuana. The pathways leading to the synthesis and release of AEA and 2-AG from neuronal and non-neuronal cells are still rather uncertain. Instead, it is known that the activity of AEA is limited by cellular uptake through a specific membrane transporter, followed by intracellular degradation by a fatty acid amide hydrolase. Together with AEA and congeners these proteins form the 'endocannabinoid system'. Here, the involvement of AEA in apoptosis and the underlying signal transduction pathways will be reviewed, along with the metabolic routes and the molecular targets of this endocannabinoid. Also, recent findings on the apoptotic potential of AEA for neuronal cell differentiation and brain development will be discussed. SN - 1350-9047 UR - https://www.unboundmedicine.com/medline/citation/12934069/The_endocannabinoid_system_anandamide_and_the_regulation_of_mammalian_cell_apoptosis_ L2 - http://dx.doi.org/10.1038/sj.cdd.4401284 DB - PRIME DP - Unbound Medicine ER -