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Shiga toxin-producing Escherichia coli in Montana: bacterial genotypes and clinical profiles.
J Infect Dis. 2003 Sep 01; 188(5):719-29.JI

Abstract

The diseases and virulence genes associated with Shiga toxin-producing Escherichia coli (STEC) are characterized incompletely. We analyzed, by polymerase chain reaction, 82 STEC isolates collected prospectively in Montana and profiled associated illnesses by patient chart review. All E. coli O157:H7 contained stx2-group genes, as well as eae, iha, espA, and ehxA; 84% contained stx1. Non-O157:H7 STEC less frequently contained stx1 (P=.046), stx2 (P<.001), iha (P<.001), eae, and espA (P=.039 for both), were isolated less often from patients treated in emergency departments (P=.022), and tended to be associated less frequently with bloody diarrhea (P=.061). There were no significant associations between stx genotype and bloody diarrhea, but isolates containing stx2c or stx(2d-activatable) were recovered more often from patients who underwent diagnostic or therapeutic procedures (P=.033). Non-O157:H7 STEC are more heterogeneous and cause bloody diarrhea less frequently than do E. coli O157:H7. Bloody diarrhea cannot be attributed simply to the stx genotype of the infecting organism.

Authors+Show Affiliations

University of Washington School of Medicine, Seattle, Washington, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12934188

Citation

Jelacic, Jill K., et al. "Shiga Toxin-producing Escherichia Coli in Montana: Bacterial Genotypes and Clinical Profiles." The Journal of Infectious Diseases, vol. 188, no. 5, 2003, pp. 719-29.
Jelacic JK, Damrow T, Chen GS, et al. Shiga toxin-producing Escherichia coli in Montana: bacterial genotypes and clinical profiles. J Infect Dis. 2003;188(5):719-29.
Jelacic, J. K., Damrow, T., Chen, G. S., Jelacic, S., Bielaszewska, M., Ciol, M., Carvalho, H. M., Melton-Celsa, A. R., O'Brien, A. D., & Tarr, P. I. (2003). Shiga toxin-producing Escherichia coli in Montana: bacterial genotypes and clinical profiles. The Journal of Infectious Diseases, 188(5), 719-29.
Jelacic JK, et al. Shiga Toxin-producing Escherichia Coli in Montana: Bacterial Genotypes and Clinical Profiles. J Infect Dis. 2003 Sep 1;188(5):719-29. PubMed PMID: 12934188.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Shiga toxin-producing Escherichia coli in Montana: bacterial genotypes and clinical profiles. AU - Jelacic,Jill K, AU - Damrow,Todd, AU - Chen,Gilbert S, AU - Jelacic,Srdjan, AU - Bielaszewska,Martina, AU - Ciol,Marcia, AU - Carvalho,Humberto M, AU - Melton-Celsa,Angela R, AU - O'Brien,Alison D, AU - Tarr,Phillip I, Y1 - 2003/08/15/ PY - 2002/11/01/received PY - 2003/03/06/accepted PY - 2003/8/23/pubmed PY - 2003/10/10/medline PY - 2003/8/23/entrez SP - 719 EP - 29 JF - The Journal of infectious diseases JO - J. Infect. Dis. VL - 188 IS - 5 N2 - The diseases and virulence genes associated with Shiga toxin-producing Escherichia coli (STEC) are characterized incompletely. We analyzed, by polymerase chain reaction, 82 STEC isolates collected prospectively in Montana and profiled associated illnesses by patient chart review. All E. coli O157:H7 contained stx2-group genes, as well as eae, iha, espA, and ehxA; 84% contained stx1. Non-O157:H7 STEC less frequently contained stx1 (P=.046), stx2 (P<.001), iha (P<.001), eae, and espA (P=.039 for both), were isolated less often from patients treated in emergency departments (P=.022), and tended to be associated less frequently with bloody diarrhea (P=.061). There were no significant associations between stx genotype and bloody diarrhea, but isolates containing stx2c or stx(2d-activatable) were recovered more often from patients who underwent diagnostic or therapeutic procedures (P=.033). Non-O157:H7 STEC are more heterogeneous and cause bloody diarrhea less frequently than do E. coli O157:H7. Bloody diarrhea cannot be attributed simply to the stx genotype of the infecting organism. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/12934188/Shiga_toxin_producing_Escherichia_coli_in_Montana:_bacterial_genotypes_and_clinical_profiles_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1086/376999 DB - PRIME DP - Unbound Medicine ER -