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[Expression of Bcl-2 and Bax protein in endometriosis].
Hunan Yi Ke Da Xue Xue Bao. 2003 Apr; 28(2):102-6.HY

Abstract

OBJECTIVE

To study the pathophysiological effect of the expression of the apoptosis-regulating protein Bcl-2 and Bax in endometrosis.

METHOD

Samples were obtained from 16 patients with adenomyosis, 12 ovarian endometriosis, and 17 normal endometrum. Bcl-2 and Bax expression were examined by immunohistochemical ABC staining with specific monoclonal antibodies.

RESULTS

1. The expression of Bcl-2 or Bax in the eutopic endometrium was the same as the normal endometrium and their immunoreactivity was found predominately in the glandular epithelial cells, showing obvious cyclic changes. 2. The Bcl-2 and Bax expression in adenomyosis was not the cyclic change in ectopic glandular cells. 3. Less expression of Bcl-2 and Bax was found in the ovarian endometriosis.

CONCLUSIONS

1. The Bcl-2 and Bax cyclic change may play an important role in the proliferation and physiologic death of normal and eutopic endometrial glandular epithelial cells. 2. Bcl-2 may play an important role in forming adenomyosis. 3. Bcl-2 may be the cause of forming chocolate cyst by prompting apoptosis.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Second Xingya Hospital, Central South University, Changsha 410011, China.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

12934347

Citation

Huang, Feng-ying, et al. "[Expression of Bcl-2 and Bax Protein in Endometriosis]." Hunan Yi Ke Da Xue Xue Bao = Hunan Yike Daxue Xuebao = Bulletin of Hunan Medical University, vol. 28, no. 2, 2003, pp. 102-6.
Huang FY, Lin QH, Fang XL. [Expression of Bcl-2 and Bax protein in endometriosis]. Hunan Yi Ke Da Xue Xue Bao. 2003;28(2):102-6.
Huang, F. Y., Lin, Q. H., & Fang, X. L. (2003). [Expression of Bcl-2 and Bax protein in endometriosis]. Hunan Yi Ke Da Xue Xue Bao = Hunan Yike Daxue Xuebao = Bulletin of Hunan Medical University, 28(2), 102-6.
Huang FY, Lin QH, Fang XL. [Expression of Bcl-2 and Bax Protein in Endometriosis]. Hunan Yi Ke Da Xue Xue Bao. 2003;28(2):102-6. PubMed PMID: 12934347.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Expression of Bcl-2 and Bax protein in endometriosis]. AU - Huang,Feng-ying, AU - Lin,Qiu-hua, AU - Fang,Xiao-ling, PY - 2003/8/26/pubmed PY - 2004/8/11/medline PY - 2003/8/26/entrez SP - 102 EP - 6 JF - Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University JO - Hunan Yi Ke Da Xue Xue Bao VL - 28 IS - 2 N2 - OBJECTIVE: To study the pathophysiological effect of the expression of the apoptosis-regulating protein Bcl-2 and Bax in endometrosis. METHOD: Samples were obtained from 16 patients with adenomyosis, 12 ovarian endometriosis, and 17 normal endometrum. Bcl-2 and Bax expression were examined by immunohistochemical ABC staining with specific monoclonal antibodies. RESULTS: 1. The expression of Bcl-2 or Bax in the eutopic endometrium was the same as the normal endometrium and their immunoreactivity was found predominately in the glandular epithelial cells, showing obvious cyclic changes. 2. The Bcl-2 and Bax expression in adenomyosis was not the cyclic change in ectopic glandular cells. 3. Less expression of Bcl-2 and Bax was found in the ovarian endometriosis. CONCLUSIONS: 1. The Bcl-2 and Bax cyclic change may play an important role in the proliferation and physiologic death of normal and eutopic endometrial glandular epithelial cells. 2. Bcl-2 may play an important role in forming adenomyosis. 3. Bcl-2 may be the cause of forming chocolate cyst by prompting apoptosis. SN - 1000-5625 UR - https://www.unboundmedicine.com/medline/citation/12934347/[Expression_of_Bcl_2_and_Bax_protein_in_endometriosis]_ L2 - http://www.diseaseinfosearch.org/result/2537 DB - PRIME DP - Unbound Medicine ER -