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From skin disorders to venous leg ulcers: pathophysiology and efficacy of Daflon 500 mg in ulcer healing.
Angiology. 2003 Jul-Aug; 54 Suppl 1:S45-50.A

Abstract

The standard treatments for venous diseases of the lower limb include compression bandaging and stockings as well as surgical removal of varicose veins. There are a number of conditions in which these conventional treatments are ineffective, particularly in the management of leg ulceration. Drug treatments for healing venous leg ulcers have yet to be developed to the stage of good clinical efficacy, but these may assist in the management of patients. Flavonoid drugs have been widely used in the management of the symptoms of venous disease for many years and have recently been studied in some detail to assess their effects on the microcirculation. Work in animal models of ischemia-reperfusion show that MPFF (micronized purified flavonoid fraction) modulates leukocyte adhesion and prevents endothelial damage. Similar biochemical effects have been observed in patients with venous disease and may explain the efficacy of this drug in the management of edema and other symptoms of venous disease. There is clinical evidence that MPFF modifies venous leg ulcer healing.

Authors+Show Affiliations

Department of Surgery, The Middlesex Hospital, London, UK. p.coleridgesmith@ucl.ac.uk

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

12934756

Citation

Coleridge Smith, Philip D.. "From Skin Disorders to Venous Leg Ulcers: Pathophysiology and Efficacy of Daflon 500 Mg in Ulcer Healing." Angiology, vol. 54 Suppl 1, 2003, pp. S45-50.
Coleridge Smith PD. From skin disorders to venous leg ulcers: pathophysiology and efficacy of Daflon 500 mg in ulcer healing. Angiology. 2003;54 Suppl 1:S45-50.
Coleridge Smith, P. D. (2003). From skin disorders to venous leg ulcers: pathophysiology and efficacy of Daflon 500 mg in ulcer healing. Angiology, 54 Suppl 1, S45-50.
Coleridge Smith PD. From Skin Disorders to Venous Leg Ulcers: Pathophysiology and Efficacy of Daflon 500 Mg in Ulcer Healing. Angiology. 2003 Jul-Aug;54 Suppl 1:S45-50. PubMed PMID: 12934756.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - From skin disorders to venous leg ulcers: pathophysiology and efficacy of Daflon 500 mg in ulcer healing. A1 - Coleridge Smith,Philip D, PY - 2003/8/26/pubmed PY - 2003/9/11/medline PY - 2003/8/26/entrez SP - S45 EP - 50 JF - Angiology JO - Angiology VL - 54 Suppl 1 N2 - The standard treatments for venous diseases of the lower limb include compression bandaging and stockings as well as surgical removal of varicose veins. There are a number of conditions in which these conventional treatments are ineffective, particularly in the management of leg ulceration. Drug treatments for healing venous leg ulcers have yet to be developed to the stage of good clinical efficacy, but these may assist in the management of patients. Flavonoid drugs have been widely used in the management of the symptoms of venous disease for many years and have recently been studied in some detail to assess their effects on the microcirculation. Work in animal models of ischemia-reperfusion show that MPFF (micronized purified flavonoid fraction) modulates leukocyte adhesion and prevents endothelial damage. Similar biochemical effects have been observed in patients with venous disease and may explain the efficacy of this drug in the management of edema and other symptoms of venous disease. There is clinical evidence that MPFF modifies venous leg ulcer healing. SN - 0003-3197 UR - https://www.unboundmedicine.com/medline/citation/12934756/From_skin_disorders_to_venous_leg_ulcers:_pathophysiology_and_efficacy_of_Daflon_500_mg_in_ulcer_healing_ L2 - http://journals.sagepub.com/doi/full/10.1177/0003319703054001s06?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -