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Current treatments for Alzheimer's disease: cholinesterase inhibitors.
J Clin Psychiatry. 2003; 64 Suppl 9:11-7.JC

Abstract

The current recommended standard of care for the symptomatic treatment of mild to moderate Alzheimer's disease is cholinesterase inhibitors. In short- and long-term studies, the 3 cholinesterase inhibitors most commonly used, donepezil, rivastigmine, and galantamine, have demonstrated efficacy in improving not only cognition but also function and behavior in patients suffering from mild to severe cases of Alzheimer's disease and other forms of dementia. However, the benefits of cholinesterase inhibitors in treating the broad spectrum of symptoms associated with Alzheimer's disease are not sustained indefinitely, and the illness continues to progress even while patients are receiving treatment. Additionally, while temporary stabilization may occur, there is typically only a modest improvement from baseline, and side effects from treatment with cholinesterase inhibitors can be too severe for some patients to tolerate. Therefore, additional therapies for Alzheimer's disease still need to be developed that include more tolerable agents with alternative mechanisms of action and broader efficacy.

Authors+Show Affiliations

Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA. rdoody@bcm.tmc.edu

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

12934969

Citation

Doody, Rachelle S.. "Current Treatments for Alzheimer's Disease: Cholinesterase Inhibitors." The Journal of Clinical Psychiatry, vol. 64 Suppl 9, 2003, pp. 11-7.
Doody RS. Current treatments for Alzheimer's disease: cholinesterase inhibitors. J Clin Psychiatry. 2003;64 Suppl 9:11-7.
Doody, R. S. (2003). Current treatments for Alzheimer's disease: cholinesterase inhibitors. The Journal of Clinical Psychiatry, 64 Suppl 9, 11-7.
Doody RS. Current Treatments for Alzheimer's Disease: Cholinesterase Inhibitors. J Clin Psychiatry. 2003;64 Suppl 9:11-7. PubMed PMID: 12934969.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Current treatments for Alzheimer's disease: cholinesterase inhibitors. A1 - Doody,Rachelle S, PY - 2003/8/26/pubmed PY - 2003/9/18/medline PY - 2003/8/26/entrez SP - 11 EP - 7 JF - The Journal of clinical psychiatry JO - J Clin Psychiatry VL - 64 Suppl 9 N2 - The current recommended standard of care for the symptomatic treatment of mild to moderate Alzheimer's disease is cholinesterase inhibitors. In short- and long-term studies, the 3 cholinesterase inhibitors most commonly used, donepezil, rivastigmine, and galantamine, have demonstrated efficacy in improving not only cognition but also function and behavior in patients suffering from mild to severe cases of Alzheimer's disease and other forms of dementia. However, the benefits of cholinesterase inhibitors in treating the broad spectrum of symptoms associated with Alzheimer's disease are not sustained indefinitely, and the illness continues to progress even while patients are receiving treatment. Additionally, while temporary stabilization may occur, there is typically only a modest improvement from baseline, and side effects from treatment with cholinesterase inhibitors can be too severe for some patients to tolerate. Therefore, additional therapies for Alzheimer's disease still need to be developed that include more tolerable agents with alternative mechanisms of action and broader efficacy. SN - 0160-6689 UR - https://www.unboundmedicine.com/medline/citation/12934969/Current_treatments_for_Alzheimer's_disease:_cholinesterase_inhibitors_ L2 - http://www.psychiatrist.com/jcp/article/pages/2003/v64s09/v64s0903.aspx DB - PRIME DP - Unbound Medicine ER -