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Polymorphisms in the coagulation factor VII gene and the risk of myocardial infarction in patients undergoing coronary angiography.
Chin Med J (Engl). 2003 Aug; 116(8):1194-7.CM

Abstract

OBJECTIVE

To investigate whether coagulation factor VII (FVII) polymorphisms play a role in the pathogenesis of coronary artery disease (CAD) and/or myocardial infarction (MI) in a series of Hans.

METHODS

The Arg(353)Gln and HVR4 polymorphisms of FVII gene were determined in 374 patients undergoing selective coronary angiography by PCR and restriction fragment length polymorphism assay.

RESULTS

The FVII genotype distribution was in accordance with Hardy-Weinberg equilibrium. The frequencies of FVII genotypes or alleles did not show significant differences between the CAD group and the controls or between the males and the females. The frequencies of carriers of the Gln(353) allele and (Arg/Gln + Gln/Gln) genotypes were significantly higher in the CAD patients without MI than in those with MI (P = 0.031, odds ratio 0.37, 95% CI: 0.15 - 0.94). However, HVR4 polymorphisms were not significantly different between the two groups (P > 0.05).

CONCLUSION

Carrying the F VII Gln(353) gene may be a protective factor against MI in the Chinese Hans.

Authors+Show Affiliations

Department of Cardiology, Second Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou 310009, China. xugengzju@21cn.com.cnNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12935410

Citation

Xu, Geng, et al. "Polymorphisms in the Coagulation Factor VII Gene and the Risk of Myocardial Infarction in Patients Undergoing Coronary Angiography." Chinese Medical Journal, vol. 116, no. 8, 2003, pp. 1194-7.
Xu G, Jin G, Fu G, et al. Polymorphisms in the coagulation factor VII gene and the risk of myocardial infarction in patients undergoing coronary angiography. Chin Med J (Engl). 2003;116(8):1194-7.
Xu, G., Jin, G., Fu, G., Ma, J., Shi, Y., Tang, O., & Shan, J. (2003). Polymorphisms in the coagulation factor VII gene and the risk of myocardial infarction in patients undergoing coronary angiography. Chinese Medical Journal, 116(8), 1194-7.
Xu G, et al. Polymorphisms in the Coagulation Factor VII Gene and the Risk of Myocardial Infarction in Patients Undergoing Coronary Angiography. Chin Med J (Engl). 2003;116(8):1194-7. PubMed PMID: 12935410.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Polymorphisms in the coagulation factor VII gene and the risk of myocardial infarction in patients undergoing coronary angiography. AU - Xu,Geng, AU - Jin,Guodong, AU - Fu,Guosheng, AU - Ma,Ji, AU - Shi,Yuping, AU - Tang,Oushan, AU - Shan,Jiang, PY - 2003/8/26/pubmed PY - 2003/11/8/medline PY - 2003/8/26/entrez SP - 1194 EP - 7 JF - Chinese medical journal JO - Chin Med J (Engl) VL - 116 IS - 8 N2 - OBJECTIVE: To investigate whether coagulation factor VII (FVII) polymorphisms play a role in the pathogenesis of coronary artery disease (CAD) and/or myocardial infarction (MI) in a series of Hans. METHODS: The Arg(353)Gln and HVR4 polymorphisms of FVII gene were determined in 374 patients undergoing selective coronary angiography by PCR and restriction fragment length polymorphism assay. RESULTS: The FVII genotype distribution was in accordance with Hardy-Weinberg equilibrium. The frequencies of FVII genotypes or alleles did not show significant differences between the CAD group and the controls or between the males and the females. The frequencies of carriers of the Gln(353) allele and (Arg/Gln + Gln/Gln) genotypes were significantly higher in the CAD patients without MI than in those with MI (P = 0.031, odds ratio 0.37, 95% CI: 0.15 - 0.94). However, HVR4 polymorphisms were not significantly different between the two groups (P > 0.05). CONCLUSION: Carrying the F VII Gln(353) gene may be a protective factor against MI in the Chinese Hans. SN - 0366-6999 UR - https://www.unboundmedicine.com/medline/citation/12935410/Polymorphisms_in_the_coagulation_factor_VII_gene_and_the_risk_of_myocardial_infarction_in_patients_undergoing_coronary_angiography_ L2 - https://medlineplus.gov/heartattack.html DB - PRIME DP - Unbound Medicine ER -