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Sensitive determination of mianserin and setiptiline in body fluids by gas chromatography with surface ionization detection (GC-SID).
Leg Med (Tokyo). 2000 Aug; 2(2):115-8.LM

Abstract

Tetracyclic antidepressants, mianserin and setiptiline, in human body fluids have been found measurable with high sensitivity by gas chromatography (GC) with surface ionization detection (SID). The compounds in human whole blood or urine samples were extracted by solid-phase extraction using Bond Elut C(18) cartridges. The recoveries of both compounds from the body fluids were above 85%. For quantitation of mianserin, 25 ng of setiptiline was used as internal standard; and for quantitation of setiptiline, vice versa. The calibration curves for spiked whole blood or urine samples were linear in the range of 1.25-50 ng/ml. The detection limit of mianserin and setiptiline was about 1 ng/ml, which is comparable to those obtained by the previous GC-mass spectrometry methods. Our method seems very useful for determination of mianserin and setiptiline in forensic and clinical toxicology, because of high sensitivity, low background impurities and easy handling of the GC instrument.

Authors+Show Affiliations

Department of Legal Medicine and Bioethics, Nagoya University Graduate School of Medicine, Nagoya 464-8550, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12935454

Citation

Ishii, A, et al. "Sensitive Determination of Mianserin and Setiptiline in Body Fluids By Gas Chromatography With Surface Ionization Detection (GC-SID)." Legal Medicine (Tokyo, Japan), vol. 2, no. 2, 2000, pp. 115-8.
Ishii A, Kurihara R, Kojima T, et al. Sensitive determination of mianserin and setiptiline in body fluids by gas chromatography with surface ionization detection (GC-SID). Leg Med (Tokyo). 2000;2(2):115-8.
Ishii, A., Kurihara, R., Kojima, T., Sano, T., Mizuno, Y., Yamakawa, Y., & Katsumata, Y. (2000). Sensitive determination of mianserin and setiptiline in body fluids by gas chromatography with surface ionization detection (GC-SID). Legal Medicine (Tokyo, Japan), 2(2), 115-8.
Ishii A, et al. Sensitive Determination of Mianserin and Setiptiline in Body Fluids By Gas Chromatography With Surface Ionization Detection (GC-SID). Leg Med (Tokyo). 2000;2(2):115-8. PubMed PMID: 12935454.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sensitive determination of mianserin and setiptiline in body fluids by gas chromatography with surface ionization detection (GC-SID). AU - Ishii,A, AU - Kurihara,R, AU - Kojima,T, AU - Sano,T, AU - Mizuno,Y, AU - Yamakawa,Y, AU - Katsumata,Y, PY - 2003/8/26/pubmed PY - 2003/8/26/medline PY - 2003/8/26/entrez SP - 115 EP - 8 JF - Legal medicine (Tokyo, Japan) JO - Leg Med (Tokyo) VL - 2 IS - 2 N2 - Tetracyclic antidepressants, mianserin and setiptiline, in human body fluids have been found measurable with high sensitivity by gas chromatography (GC) with surface ionization detection (SID). The compounds in human whole blood or urine samples were extracted by solid-phase extraction using Bond Elut C(18) cartridges. The recoveries of both compounds from the body fluids were above 85%. For quantitation of mianserin, 25 ng of setiptiline was used as internal standard; and for quantitation of setiptiline, vice versa. The calibration curves for spiked whole blood or urine samples were linear in the range of 1.25-50 ng/ml. The detection limit of mianserin and setiptiline was about 1 ng/ml, which is comparable to those obtained by the previous GC-mass spectrometry methods. Our method seems very useful for determination of mianserin and setiptiline in forensic and clinical toxicology, because of high sensitivity, low background impurities and easy handling of the GC instrument. SN - 1344-6223 UR - https://www.unboundmedicine.com/medline/citation/12935454/Sensitive_determination_of_mianserin_and_setiptiline_in_body_fluids_by_gas_chromatography_with_surface_ionization_detection__GC_SID__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1344-6223(00)80035-8 DB - PRIME DP - Unbound Medicine ER -
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