Tags

Type your tag names separated by a space and hit enter

Expression of cytokines, neurotrophins, neurotrophin receptors and NOS mRNA in dorsal root ganglion of a rat tourniquet model.
Leg Med (Tokyo). 2003 Mar; 5 Suppl 1:S271-4.LM

Abstract

We studied temporal changes in mRNA expression patterns for nitric oxide synthase (NOS), cytokines, neurotrophins and neurotrophin receptors in the dorsal root ganglion (DRG) of the rat, after application of a tourniquet to the hind limb. Collapsed myelin and degenerated axons were observed in the tourniquet segment of the sciatic nerve. Gene expression level of inducible nitric oxide synthase (iNOS) and neuronal nitric oxide synthase (nNOS) was significantly increased in ipsilateral DRG samples at 4h after application of the tourniquet but not in the contralateral or control DRG samples. Upregulation of tumor necrosis factor (TNF)-alpha, activating transcription factor (ATF)-3 and neurotrophin-3 (NT3) expressions began at 1h after application of the tourniquet in ipsilateral DRGs. It is likely that transient expression of these molecules triggers secondary events that may be beneficial to wound repair and regeneration.

Authors+Show Affiliations

Department of Legal Medicine, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960-1295, Japan. mizusawa@fmu.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12935608

Citation

Mizusawa, Ikubumi, et al. "Expression of Cytokines, Neurotrophins, Neurotrophin Receptors and NOS mRNA in Dorsal Root Ganglion of a Rat Tourniquet Model." Legal Medicine (Tokyo, Japan), vol. 5 Suppl 1, 2003, pp. S271-4.
Mizusawa I, Abe S, Kanno K, et al. Expression of cytokines, neurotrophins, neurotrophin receptors and NOS mRNA in dorsal root ganglion of a rat tourniquet model. Leg Med (Tokyo). 2003;5 Suppl 1:S271-4.
Mizusawa, I., Abe, S., Kanno, K., Yabashi, A., Honda, T., Suto, M., & Hiraiwa, K. (2003). Expression of cytokines, neurotrophins, neurotrophin receptors and NOS mRNA in dorsal root ganglion of a rat tourniquet model. Legal Medicine (Tokyo, Japan), 5 Suppl 1, S271-4.
Mizusawa I, et al. Expression of Cytokines, Neurotrophins, Neurotrophin Receptors and NOS mRNA in Dorsal Root Ganglion of a Rat Tourniquet Model. Leg Med (Tokyo). 2003;5 Suppl 1:S271-4. PubMed PMID: 12935608.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Expression of cytokines, neurotrophins, neurotrophin receptors and NOS mRNA in dorsal root ganglion of a rat tourniquet model. AU - Mizusawa,Ikubumi, AU - Abe,Sumiko, AU - Kanno,Katsuyuki, AU - Yabashi,Atsuko, AU - Honda,Takashi, AU - Suto,Miwako, AU - Hiraiwa,Kouichi, PY - 2003/8/26/pubmed PY - 2003/12/4/medline PY - 2003/8/26/entrez SP - S271 EP - 4 JF - Legal medicine (Tokyo, Japan) JO - Leg Med (Tokyo) VL - 5 Suppl 1 N2 - We studied temporal changes in mRNA expression patterns for nitric oxide synthase (NOS), cytokines, neurotrophins and neurotrophin receptors in the dorsal root ganglion (DRG) of the rat, after application of a tourniquet to the hind limb. Collapsed myelin and degenerated axons were observed in the tourniquet segment of the sciatic nerve. Gene expression level of inducible nitric oxide synthase (iNOS) and neuronal nitric oxide synthase (nNOS) was significantly increased in ipsilateral DRG samples at 4h after application of the tourniquet but not in the contralateral or control DRG samples. Upregulation of tumor necrosis factor (TNF)-alpha, activating transcription factor (ATF)-3 and neurotrophin-3 (NT3) expressions began at 1h after application of the tourniquet in ipsilateral DRGs. It is likely that transient expression of these molecules triggers secondary events that may be beneficial to wound repair and regeneration. SN - 1344-6223 UR - https://www.unboundmedicine.com/medline/citation/12935608/Expression_of_cytokines_neurotrophins_neurotrophin_receptors_and_NOS_mRNA_in_dorsal_root_ganglion_of_a_rat_tourniquet_model_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1344622302001475 DB - PRIME DP - Unbound Medicine ER -