Tags

Type your tag names separated by a space and hit enter

Alcohol-mediated enhancement of postprandial lipemia: a contributing factor to an increase in plasma HDL and a decrease in risk of cardiovascular disease.
Am J Clin Nutr. 2003 Sep; 78(3):391-9.AJ

Abstract

BACKGROUND

Moderate alcohol consumption increases plasma HDL and lowers cardiovascular disease risk while transiently enhancing postprandial lipemia.

OBJECTIVE

We hypothesized that the alcohol-mediated increase in postprandial triacylglycerol-rich lipoproteins (TRLs) and their clearance elevate HDL cholesterol and reverse cholesterol transport.

DESIGN

We determined the effect in normolipidemic humans (n = 14) of postprandial lipemia produced 4 h after a test meal (M) or a test meal + 0.5 g alcohol/kg body wt (M+A) on postprandial changes in plasma lipids and on the balance of cholesterol between TRL and the cholesterol-rich LDL and HDL fractions (CRL) or red blood cells (RBCs) in fresh and incubated plasma or blood.

RESULTS

Postprandial lipemia after the M and M+A test meals caused a 56% and 89% increase in plasma triacylglycerol, a 30% and 74% increase in TRL cholesterol, and a 3.8% and 6.6% decrease in CRL cholesterol, respectively. In vitro reaction of endogenous lecithin:cholesterol acyltransferase (EC 2.3.1.43) and cholesteryl ester transfer proteins via incubation of fasting plasma samples and postprandial M and M+A plasma samples for 16 h increased TRL cholesterol by 22.8% (0.08 mmol/L), 32.6% (0.16 mmol/L), and 45.8% (0.28 mmol/L) in plasma and by 71.1% (0.27 mmol/L), 89.4% (0.45 mmol/L), and 112.5% (0.70 mmol/L) in RBC-enriched blood, respectively. After the in vitro lipolysis of TRL, the elevation of HDL cholesterol in postprandial M+A plasma, but not in postprandial M plasma, was significantly greater than in fasting plasma.

CONCLUSION

The alcohol-mediated increase in postprandial TRL flux and the hepatic removal of postprandial TRL after the acceptance of cholesterol from CRL and cell membranes contribute to increased HDL cholesterol and enhancement of reverse cholesterol transport in humans.

Authors+Show Affiliations

Department of Medicine, School of Medicine, University of Alabama, Birmingham, 35294, USA. bhchung@uab.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12936920

Citation

Chung, Byung-Hong, et al. "Alcohol-mediated Enhancement of Postprandial Lipemia: a Contributing Factor to an Increase in Plasma HDL and a Decrease in Risk of Cardiovascular Disease." The American Journal of Clinical Nutrition, vol. 78, no. 3, 2003, pp. 391-9.
Chung BH, Doran S, Liang P, et al. Alcohol-mediated enhancement of postprandial lipemia: a contributing factor to an increase in plasma HDL and a decrease in risk of cardiovascular disease. Am J Clin Nutr. 2003;78(3):391-9.
Chung, B. H., Doran, S., Liang, P., Osterlund, L., Cho, B. H., Oster, R. A., Darnell, B., & Franklin, F. (2003). Alcohol-mediated enhancement of postprandial lipemia: a contributing factor to an increase in plasma HDL and a decrease in risk of cardiovascular disease. The American Journal of Clinical Nutrition, 78(3), 391-9.
Chung BH, et al. Alcohol-mediated Enhancement of Postprandial Lipemia: a Contributing Factor to an Increase in Plasma HDL and a Decrease in Risk of Cardiovascular Disease. Am J Clin Nutr. 2003;78(3):391-9. PubMed PMID: 12936920.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol-mediated enhancement of postprandial lipemia: a contributing factor to an increase in plasma HDL and a decrease in risk of cardiovascular disease. AU - Chung,Byung-Hong, AU - Doran,Steve, AU - Liang,Ping, AU - Osterlund,Laura, AU - Cho,B H Simon, AU - Oster,Robert A, AU - Darnell,Betty, AU - Franklin,Frank, PY - 2003/8/26/pubmed PY - 2003/9/27/medline PY - 2003/8/26/entrez SP - 391 EP - 9 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 78 IS - 3 N2 - BACKGROUND: Moderate alcohol consumption increases plasma HDL and lowers cardiovascular disease risk while transiently enhancing postprandial lipemia. OBJECTIVE: We hypothesized that the alcohol-mediated increase in postprandial triacylglycerol-rich lipoproteins (TRLs) and their clearance elevate HDL cholesterol and reverse cholesterol transport. DESIGN: We determined the effect in normolipidemic humans (n = 14) of postprandial lipemia produced 4 h after a test meal (M) or a test meal + 0.5 g alcohol/kg body wt (M+A) on postprandial changes in plasma lipids and on the balance of cholesterol between TRL and the cholesterol-rich LDL and HDL fractions (CRL) or red blood cells (RBCs) in fresh and incubated plasma or blood. RESULTS: Postprandial lipemia after the M and M+A test meals caused a 56% and 89% increase in plasma triacylglycerol, a 30% and 74% increase in TRL cholesterol, and a 3.8% and 6.6% decrease in CRL cholesterol, respectively. In vitro reaction of endogenous lecithin:cholesterol acyltransferase (EC 2.3.1.43) and cholesteryl ester transfer proteins via incubation of fasting plasma samples and postprandial M and M+A plasma samples for 16 h increased TRL cholesterol by 22.8% (0.08 mmol/L), 32.6% (0.16 mmol/L), and 45.8% (0.28 mmol/L) in plasma and by 71.1% (0.27 mmol/L), 89.4% (0.45 mmol/L), and 112.5% (0.70 mmol/L) in RBC-enriched blood, respectively. After the in vitro lipolysis of TRL, the elevation of HDL cholesterol in postprandial M+A plasma, but not in postprandial M plasma, was significantly greater than in fasting plasma. CONCLUSION: The alcohol-mediated increase in postprandial TRL flux and the hepatic removal of postprandial TRL after the acceptance of cholesterol from CRL and cell membranes contribute to increased HDL cholesterol and enhancement of reverse cholesterol transport in humans. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/12936920/Alcohol_mediated_enhancement_of_postprandial_lipemia:_a_contributing_factor_to_an_increase_in_plasma_HDL_and_a_decrease_in_risk_of_cardiovascular_disease_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/78.3.391 DB - PRIME DP - Unbound Medicine ER -