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Association of low 25-hydroxyvitamin D concentrations with elevated parathyroid hormone concentrations and low cortical bone density in early pubertal and prepubertal Finnish girls.
Am J Clin Nutr 2003; 78(3):485-92AJ

Abstract

BACKGROUND

Very few studies have evaluated both parathyroid hormone (PTH) and 25-hydroxyvitamin D [25(OH)D] and their effects on bone mass in children.

OBJECTIVE

We studied the associations of serum 25(OH)D and intact PTH (iPTH) with bone mineral content (BMC) and bone mineral density (BMD) at different bone sites and the relation between serum 25(OH)D and iPTH in early pubertal and prepubertal Finnish girls.

DESIGN

The subjects were 10-12-y-old girls (n = 193) at Tanner stage 1 or 2, who reported a mean (+/- SD) dietary calcium intake of 733 +/- 288 mg/d. 25(OH)D, iPTH, tartrate-resistant acid phosphatase 5b (TRAP 5b), urinary calcium excretion, BMC, areal BMD, and volumetric BMD were assessed by using different methods.

RESULTS

Thirty-two percent of the girls were vitamin D deficient [serum 25(OH)D < or = 25 nmol/L], and 46% of the girls had an insufficient concentration (26-40 nmol/L). iPTH and TRAP 5b concentrations were significantly higher in the deficient group than in the insufficient and sufficient groups [iPTH: 43.9 +/- 15.7 compared with 38.6 +/- 11.2 pg/L (P = 0.049) and 32.7 +/- 12.1 pg/L (P < 0.001), respectively; TRAP 5b: 12.2 +/- 2.9 compared with 11.0 +/- 2.8 U/L (P = 0.009) and 10.9 +/- 1.9 U/L (P = 0.006), respectively]. The girls in the deficient group also had significantly lower cortical volumetric BMD of the distal radius (P < 0.001) and tibia shaft (P = 0.002). High iPTH concentrations were also associated with low total-body apparent mineral density and urinary calcium excretion (P < 0.007).

CONCLUSIONS

Vitamin D-deficient girls have low cortical BMD and high iPTH concentrations, which are consistent with secondary hyperparathyroidism. A low vitamin D concentration accompanied by high bone resorption (TRAP 5b) may limit the accretion of bone mass in young girls.

Authors+Show Affiliations

Department of Health Sciences, University of Jyväskylä, Jyväskylä, Finland. cheng@sport.jyu.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12936933

Citation

Cheng, Sulin, et al. "Association of Low 25-hydroxyvitamin D Concentrations With Elevated Parathyroid Hormone Concentrations and Low Cortical Bone Density in Early Pubertal and Prepubertal Finnish Girls." The American Journal of Clinical Nutrition, vol. 78, no. 3, 2003, pp. 485-92.
Cheng S, Tylavsky F, Kröger H, et al. Association of low 25-hydroxyvitamin D concentrations with elevated parathyroid hormone concentrations and low cortical bone density in early pubertal and prepubertal Finnish girls. Am J Clin Nutr. 2003;78(3):485-92.
Cheng, S., Tylavsky, F., Kröger, H., Kärkkäinen, M., Lyytikäinen, A., Koistinen, A., ... Lamberg-Allardt, C. (2003). Association of low 25-hydroxyvitamin D concentrations with elevated parathyroid hormone concentrations and low cortical bone density in early pubertal and prepubertal Finnish girls. The American Journal of Clinical Nutrition, 78(3), pp. 485-92.
Cheng S, et al. Association of Low 25-hydroxyvitamin D Concentrations With Elevated Parathyroid Hormone Concentrations and Low Cortical Bone Density in Early Pubertal and Prepubertal Finnish Girls. Am J Clin Nutr. 2003;78(3):485-92. PubMed PMID: 12936933.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of low 25-hydroxyvitamin D concentrations with elevated parathyroid hormone concentrations and low cortical bone density in early pubertal and prepubertal Finnish girls. AU - Cheng,Sulin, AU - Tylavsky,Frances, AU - Kröger,Heikki, AU - Kärkkäinen,Merja, AU - Lyytikäinen,Arja, AU - Koistinen,Arvo, AU - Mahonen,Anitta, AU - Alen,Markku, AU - Halleen,Jussi, AU - Väänänen,Kalervo, AU - Lamberg-Allardt,Christel, PY - 2003/8/26/pubmed PY - 2003/9/27/medline PY - 2003/8/26/entrez SP - 485 EP - 92 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 78 IS - 3 N2 - BACKGROUND: Very few studies have evaluated both parathyroid hormone (PTH) and 25-hydroxyvitamin D [25(OH)D] and their effects on bone mass in children. OBJECTIVE: We studied the associations of serum 25(OH)D and intact PTH (iPTH) with bone mineral content (BMC) and bone mineral density (BMD) at different bone sites and the relation between serum 25(OH)D and iPTH in early pubertal and prepubertal Finnish girls. DESIGN: The subjects were 10-12-y-old girls (n = 193) at Tanner stage 1 or 2, who reported a mean (+/- SD) dietary calcium intake of 733 +/- 288 mg/d. 25(OH)D, iPTH, tartrate-resistant acid phosphatase 5b (TRAP 5b), urinary calcium excretion, BMC, areal BMD, and volumetric BMD were assessed by using different methods. RESULTS: Thirty-two percent of the girls were vitamin D deficient [serum 25(OH)D < or = 25 nmol/L], and 46% of the girls had an insufficient concentration (26-40 nmol/L). iPTH and TRAP 5b concentrations were significantly higher in the deficient group than in the insufficient and sufficient groups [iPTH: 43.9 +/- 15.7 compared with 38.6 +/- 11.2 pg/L (P = 0.049) and 32.7 +/- 12.1 pg/L (P < 0.001), respectively; TRAP 5b: 12.2 +/- 2.9 compared with 11.0 +/- 2.8 U/L (P = 0.009) and 10.9 +/- 1.9 U/L (P = 0.006), respectively]. The girls in the deficient group also had significantly lower cortical volumetric BMD of the distal radius (P < 0.001) and tibia shaft (P = 0.002). High iPTH concentrations were also associated with low total-body apparent mineral density and urinary calcium excretion (P < 0.007). CONCLUSIONS: Vitamin D-deficient girls have low cortical BMD and high iPTH concentrations, which are consistent with secondary hyperparathyroidism. A low vitamin D concentration accompanied by high bone resorption (TRAP 5b) may limit the accretion of bone mass in young girls. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/12936933/Association_of_low_25_hydroxyvitamin_D_concentrations_with_elevated_parathyroid_hormone_concentrations_and_low_cortical_bone_density_in_early_pubertal_and_prepubertal_Finnish_girls_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/78.3.485 DB - PRIME DP - Unbound Medicine ER -