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Case report: isolation of a European bat lyssavirus type 2a from a fatal human case of rabies encephalitis.
J Med Virol. 2003 Oct; 71(2):281-9.JM

Abstract

A 55-year-old bat conservationist was admitted to Ninewells Hospital, Dundee, Scotland, on November 11, 2002, with an acute haematemesis. He gave a 5-day history of pain and paraesthesia in the left arm, followed by increasing weakness of his limbs with evidence of an evolving encephalitis with cerebellar involvement. The patient had never been vaccinated against rabies and did not receive postexposure treatment. Using a hemi-nested reverse transcriptase-polymerase chain reaction (RT-PCR), saliva samples taken intravitam from different dates proved positive for rabies. A 400-bp region of the nucleoprotein gene was sequenced for confirmation and identified a strain of European bat lyssavirus (EBLV) type 2a. The diagnosis was confirmed using the fluorescent antibody test (FAT) and by RT-PCR on three brain samples (cerebellum, medulla, and hippocampus) taken at autopsy. In addition, a mouse inoculation test (MIT) was performed. Between 13 and 17 days postinfection, clinical signs of a rabies-like illness had developed in all five inoculated mice. Brain smears from each infected animal were positive by the FAT and viable virus was isolated. This fatal incident is only the second confirmed case of an EBLV type-2 infection in a human after exposure to bats.

Authors+Show Affiliations

Rabies Research and Diagnostic Group, Veterinary Laboratories Agency (Weybridge) [WHO Collaborating Centre for the Characterisation of Rabies and Rabies-Related Viruses], Surrey, United Kingdom. t.fooks@vla.defra.gsi.gov.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

12938204

Citation

Fooks, Anthony R., et al. "Case Report: Isolation of a European Bat Lyssavirus Type 2a From a Fatal Human Case of Rabies Encephalitis." Journal of Medical Virology, vol. 71, no. 2, 2003, pp. 281-9.
Fooks AR, McElhinney LM, Pounder DJ, et al. Case report: isolation of a European bat lyssavirus type 2a from a fatal human case of rabies encephalitis. J Med Virol. 2003;71(2):281-9.
Fooks, A. R., McElhinney, L. M., Pounder, D. J., Finnegan, C. J., Mansfield, K., Johnson, N., Brookes, S. M., Parsons, G., White, K., McIntyre, P. G., & Nathwani, D. (2003). Case report: isolation of a European bat lyssavirus type 2a from a fatal human case of rabies encephalitis. Journal of Medical Virology, 71(2), 281-9.
Fooks AR, et al. Case Report: Isolation of a European Bat Lyssavirus Type 2a From a Fatal Human Case of Rabies Encephalitis. J Med Virol. 2003;71(2):281-9. PubMed PMID: 12938204.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Case report: isolation of a European bat lyssavirus type 2a from a fatal human case of rabies encephalitis. AU - Fooks,Anthony R, AU - McElhinney,Lorraine M, AU - Pounder,Derrick J, AU - Finnegan,Christopher J, AU - Mansfield,Karen, AU - Johnson,Nicholas, AU - Brookes,Sharon M, AU - Parsons,Graham, AU - White,Kathleen, AU - McIntyre,Paul G, AU - Nathwani,Dilip, PY - 2003/8/26/pubmed PY - 2003/12/3/medline PY - 2003/8/26/entrez SP - 281 EP - 9 JF - Journal of medical virology JO - J Med Virol VL - 71 IS - 2 N2 - A 55-year-old bat conservationist was admitted to Ninewells Hospital, Dundee, Scotland, on November 11, 2002, with an acute haematemesis. He gave a 5-day history of pain and paraesthesia in the left arm, followed by increasing weakness of his limbs with evidence of an evolving encephalitis with cerebellar involvement. The patient had never been vaccinated against rabies and did not receive postexposure treatment. Using a hemi-nested reverse transcriptase-polymerase chain reaction (RT-PCR), saliva samples taken intravitam from different dates proved positive for rabies. A 400-bp region of the nucleoprotein gene was sequenced for confirmation and identified a strain of European bat lyssavirus (EBLV) type 2a. The diagnosis was confirmed using the fluorescent antibody test (FAT) and by RT-PCR on three brain samples (cerebellum, medulla, and hippocampus) taken at autopsy. In addition, a mouse inoculation test (MIT) was performed. Between 13 and 17 days postinfection, clinical signs of a rabies-like illness had developed in all five inoculated mice. Brain smears from each infected animal were positive by the FAT and viable virus was isolated. This fatal incident is only the second confirmed case of an EBLV type-2 infection in a human after exposure to bats. SN - 0146-6615 UR - https://www.unboundmedicine.com/medline/citation/12938204/Case_report:_isolation_of_a_European_bat_lyssavirus_type_2a_from_a_fatal_human_case_of_rabies_encephalitis_ L2 - https://doi.org/10.1002/jmv.10481 DB - PRIME DP - Unbound Medicine ER -