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Cardiovascular protective effects of n-3 polyunsaturated fatty acids with special emphasis on docosahexaenoic acid.
J Pharmacol Sci 2003; 92(4):308-16JP

Abstract

It is widely accepted that n-3 polyunsaturated fatty acids (PUFAs) rich in fish oils protect against several types of cardiovascular diseases such as myocardial infarction, arrhythmia, atherosclerosis, or hypertension. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) may be the active biological components of these effects. Although the precise cellular and molecular mechanisms underlying the beneficial effects are still uncertain, the protective effects of n-3 PUFAs are attributable to their direct effects on vascular smooth muscle cell (VSMC) functions. These n-3 PUFAs activate K(+)(ATP) channels and inhibit certain types of Ca(2+) channels, probably via at least 2 distinct mechanisms. N-3 PUFAs favorably alter the eicosanoid profile and regulate cytokine-induced expression of inducible nitric oxide synthase and cyclooxygenase-2 via mechanisms involving modulation of signaling transduction events. N-3 PUFAs also modulate VSMC proliferation, migration, and apoptosis. These recent data suggest that modulation of these VSMC functions contribute to the beneficial effects of n-3 PUFAs on various cardiovascular disorders. Furthermore, recent studies strongly suggest that DHA has more potent and beneficial effects than EPA. However, many questions about the cellular and molecular mechanisms still remain to be answered.

Authors+Show Affiliations

Department of Pharmacology, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Japan. hirafuji@hoku-iryo-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

12939515

Citation

Hirafuji, Masahiko, et al. "Cardiovascular Protective Effects of N-3 Polyunsaturated Fatty Acids With Special Emphasis On Docosahexaenoic Acid." Journal of Pharmacological Sciences, vol. 92, no. 4, 2003, pp. 308-16.
Hirafuji M, Machida T, Hamaue N, et al. Cardiovascular protective effects of n-3 polyunsaturated fatty acids with special emphasis on docosahexaenoic acid. J Pharmacol Sci. 2003;92(4):308-16.
Hirafuji, M., Machida, T., Hamaue, N., & Minami, M. (2003). Cardiovascular protective effects of n-3 polyunsaturated fatty acids with special emphasis on docosahexaenoic acid. Journal of Pharmacological Sciences, 92(4), pp. 308-16.
Hirafuji M, et al. Cardiovascular Protective Effects of N-3 Polyunsaturated Fatty Acids With Special Emphasis On Docosahexaenoic Acid. J Pharmacol Sci. 2003;92(4):308-16. PubMed PMID: 12939515.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardiovascular protective effects of n-3 polyunsaturated fatty acids with special emphasis on docosahexaenoic acid. AU - Hirafuji,Masahiko, AU - Machida,Takuji, AU - Hamaue,Naoya, AU - Minami,Masaru, PY - 2003/8/27/pubmed PY - 2004/5/12/medline PY - 2003/8/27/entrez SP - 308 EP - 16 JF - Journal of pharmacological sciences JO - J. Pharmacol. Sci. VL - 92 IS - 4 N2 - It is widely accepted that n-3 polyunsaturated fatty acids (PUFAs) rich in fish oils protect against several types of cardiovascular diseases such as myocardial infarction, arrhythmia, atherosclerosis, or hypertension. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) may be the active biological components of these effects. Although the precise cellular and molecular mechanisms underlying the beneficial effects are still uncertain, the protective effects of n-3 PUFAs are attributable to their direct effects on vascular smooth muscle cell (VSMC) functions. These n-3 PUFAs activate K(+)(ATP) channels and inhibit certain types of Ca(2+) channels, probably via at least 2 distinct mechanisms. N-3 PUFAs favorably alter the eicosanoid profile and regulate cytokine-induced expression of inducible nitric oxide synthase and cyclooxygenase-2 via mechanisms involving modulation of signaling transduction events. N-3 PUFAs also modulate VSMC proliferation, migration, and apoptosis. These recent data suggest that modulation of these VSMC functions contribute to the beneficial effects of n-3 PUFAs on various cardiovascular disorders. Furthermore, recent studies strongly suggest that DHA has more potent and beneficial effects than EPA. However, many questions about the cellular and molecular mechanisms still remain to be answered. SN - 1347-8613 UR - https://www.unboundmedicine.com/medline/citation/12939515/Cardiovascular_protective_effects_of_n_3_polyunsaturated_fatty_acids_with_special_emphasis_on_docosahexaenoic_acid_ L2 - https://joi.jlc.jst.go.jp/JST.JSTAGE/jphs/92.308?from=PubMed DB - PRIME DP - Unbound Medicine ER -