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Effects of dietary supplementation with isoflavones from red clover on ambulatory blood pressure and endothelial function in postmenopausal type 2 diabetes.
Diabetes Obes Metab. 2003 Sep; 5(5):325-32.DO

Abstract

OBJECTIVE

The aim of this study was to determine whether dietary supplementation with isoflavones from red clover affected ambulatory blood pressure and forearm vascular endothelial function in postmenopausal type 2 diabetic women.

DESIGN

Sixteen postmenopausal type 2 diabetics treated with diet or oral hypoglycaemic therapy completed a randomized double-blind crossover trial of dietary supplementation with isoflavones from red clover (approximately 50 mg/day) for 4 weeks compared to placebo. Twenty-four-hour ambulatory blood pressure recordings and forearm vascular responses to acetylcholine, nitroprusside and L-nitromonomethylarginine (L-NMMA) were measured at the end of each treatment period.

RESULTS

Mean daytime systolic and diastolic blood pressures were significantly lower during isoflavone therapy compared to placebo (-8.0 +/- 3.4 and -4.3 +/- 1.9 mmHg respectively, p < 0.05). The increase in forearm vascular resistance following L-NMMA was significantly greater during isoflavone supplementation (20.9 +/- 6.5) than placebo (3.7 +/- 2.9 arbitrary units, p < 0.05), suggesting an improvement in basal endothelial function. Plasma lipoproteins, glycated haemoglobin and forearm vascular responses to acetylcholine and nitroprusside did not differ significantly between isoflavone and placebo therapy.

CONCLUSION

Isoflavone supplementation from red clover may favourably influence blood pressure and endothelial function in postmenopausal type 2 diabetic women.

Authors+Show Affiliations

Department of Clinical Pharmacology, St. George Hospital UNSW, Kogarah, NSW, Australia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12940870

Citation

Howes, J B., et al. "Effects of Dietary Supplementation With Isoflavones From Red Clover On Ambulatory Blood Pressure and Endothelial Function in Postmenopausal Type 2 Diabetes." Diabetes, Obesity & Metabolism, vol. 5, no. 5, 2003, pp. 325-32.
Howes JB, Tran D, Brillante D, et al. Effects of dietary supplementation with isoflavones from red clover on ambulatory blood pressure and endothelial function in postmenopausal type 2 diabetes. Diabetes Obes Metab. 2003;5(5):325-32.
Howes, J. B., Tran, D., Brillante, D., & Howes, L. G. (2003). Effects of dietary supplementation with isoflavones from red clover on ambulatory blood pressure and endothelial function in postmenopausal type 2 diabetes. Diabetes, Obesity & Metabolism, 5(5), 325-32.
Howes JB, et al. Effects of Dietary Supplementation With Isoflavones From Red Clover On Ambulatory Blood Pressure and Endothelial Function in Postmenopausal Type 2 Diabetes. Diabetes Obes Metab. 2003;5(5):325-32. PubMed PMID: 12940870.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of dietary supplementation with isoflavones from red clover on ambulatory blood pressure and endothelial function in postmenopausal type 2 diabetes. AU - Howes,J B, AU - Tran,D, AU - Brillante,D, AU - Howes,L G, PY - 2003/8/28/pubmed PY - 2003/12/16/medline PY - 2003/8/28/entrez SP - 325 EP - 32 JF - Diabetes, obesity & metabolism JO - Diabetes Obes Metab VL - 5 IS - 5 N2 - OBJECTIVE: The aim of this study was to determine whether dietary supplementation with isoflavones from red clover affected ambulatory blood pressure and forearm vascular endothelial function in postmenopausal type 2 diabetic women. DESIGN: Sixteen postmenopausal type 2 diabetics treated with diet or oral hypoglycaemic therapy completed a randomized double-blind crossover trial of dietary supplementation with isoflavones from red clover (approximately 50 mg/day) for 4 weeks compared to placebo. Twenty-four-hour ambulatory blood pressure recordings and forearm vascular responses to acetylcholine, nitroprusside and L-nitromonomethylarginine (L-NMMA) were measured at the end of each treatment period. RESULTS: Mean daytime systolic and diastolic blood pressures were significantly lower during isoflavone therapy compared to placebo (-8.0 +/- 3.4 and -4.3 +/- 1.9 mmHg respectively, p < 0.05). The increase in forearm vascular resistance following L-NMMA was significantly greater during isoflavone supplementation (20.9 +/- 6.5) than placebo (3.7 +/- 2.9 arbitrary units, p < 0.05), suggesting an improvement in basal endothelial function. Plasma lipoproteins, glycated haemoglobin and forearm vascular responses to acetylcholine and nitroprusside did not differ significantly between isoflavone and placebo therapy. CONCLUSION: Isoflavone supplementation from red clover may favourably influence blood pressure and endothelial function in postmenopausal type 2 diabetic women. SN - 1462-8902 UR - https://www.unboundmedicine.com/medline/citation/12940870/Effects_of_dietary_supplementation_with_isoflavones_from_red_clover_on_ambulatory_blood_pressure_and_endothelial_function_in_postmenopausal_type_2_diabetes_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=1462-8902&amp;date=2003&amp;volume=5&amp;issue=5&amp;spage=325 DB - PRIME DP - Unbound Medicine ER -