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New metal complexes as potential therapeutics.
Curr Opin Chem Biol. 2003 Aug; 7(4):481-9.CO

Abstract

The many activities of metal ions in biology have stimulated the development of metal-based therapeutics. Cisplatin, as one of the leading metal-based drugs, is widely used in treatment of cancer, being especially effective against genitourinary tumors such as testicular. Significant side effects and drug resistance, however, have limited its clinical applications. Biological carriers conjugated to cisplatin analogs have improved specificity for tumor tissue, thereby reducing side effects and drug resistance. Platinum complexes with distinctively different DNA binding modes from that of cisplatin also exhibit promising pharmacological properties. Ruthenium and gold complexes with antitumor activity have also evolved. Other metal-based chemotherapeutic compounds have been investigated for potential medicinal applications, including superoxide dismutase mimics and metal-based NO donors/scavengers. These compounds have the potential to modulate the biological properties of superoxide anion and nitric oxide.

Authors+Show Affiliations

Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 01239, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

12941423

Citation

Zhang, Christiana Xin, and Stephen J. Lippard. "New Metal Complexes as Potential Therapeutics." Current Opinion in Chemical Biology, vol. 7, no. 4, 2003, pp. 481-9.
Zhang CX, Lippard SJ. New metal complexes as potential therapeutics. Curr Opin Chem Biol. 2003;7(4):481-9.
Zhang, C. X., & Lippard, S. J. (2003). New metal complexes as potential therapeutics. Current Opinion in Chemical Biology, 7(4), 481-9.
Zhang CX, Lippard SJ. New Metal Complexes as Potential Therapeutics. Curr Opin Chem Biol. 2003;7(4):481-9. PubMed PMID: 12941423.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - New metal complexes as potential therapeutics. AU - Zhang,Christiana Xin, AU - Lippard,Stephen J, PY - 2003/8/28/pubmed PY - 2004/4/8/medline PY - 2003/8/28/entrez SP - 481 EP - 9 JF - Current opinion in chemical biology JO - Curr Opin Chem Biol VL - 7 IS - 4 N2 - The many activities of metal ions in biology have stimulated the development of metal-based therapeutics. Cisplatin, as one of the leading metal-based drugs, is widely used in treatment of cancer, being especially effective against genitourinary tumors such as testicular. Significant side effects and drug resistance, however, have limited its clinical applications. Biological carriers conjugated to cisplatin analogs have improved specificity for tumor tissue, thereby reducing side effects and drug resistance. Platinum complexes with distinctively different DNA binding modes from that of cisplatin also exhibit promising pharmacological properties. Ruthenium and gold complexes with antitumor activity have also evolved. Other metal-based chemotherapeutic compounds have been investigated for potential medicinal applications, including superoxide dismutase mimics and metal-based NO donors/scavengers. These compounds have the potential to modulate the biological properties of superoxide anion and nitric oxide. SN - 1367-5931 UR - https://www.unboundmedicine.com/medline/citation/12941423/New_metal_complexes_as_potential_therapeutics_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1367593103000814 DB - PRIME DP - Unbound Medicine ER -