Tags

Type your tag names separated by a space and hit enter

[Human immunodeficiency virus infection in pregnant women. The importance of recognizing the infection during pregnancy and risk factors for perinatal transmission].
Rev Med Chil. 2003 Jun; 131(6):633-40.RM

Abstract

BACKGROUND

Using adequate infection control measures, the rate of vertical transmission of human immunodeficiency virus (HIV) during pregnancy, has been reduced to 3% in Chile.

AIM

To determine vertical transmission rate and risk factors associated to perinatal infection in pregnant women with known (KI) and unknown HIV infection (UI).

PATIENTS AND METHODS

HIV infected pregnant women whose deliveries were attended at the San Borja Arriaran Hospital were included. Antiretroviral therapy (ART) has been used since 1995 (Zidovudine 13 patients, biOtherapy 4 and triple therapy 14 patients). Newborns have received ART since 1995. Premature labor without evident cause, premature rupture of membranes, and rupture of membranes over 4 h before delivery were evaluated. Delivery was by elective cesarean section since 1993. Breast feeding was avoided. Pregnant women with UI (suspected disease after delivery due to child or mother pathology) did not received ART. Delivery and breast feeding were managed with common obstetrical-neonatal criteria.

RESULTS

Fifty three HIV infected pregnant women were studied (43 with KI and 10 with UI). Four children (36.4%) from the KI group and seven (63.6%) from the UI group became infected. The global rate of vertical transmission among KI group was significantly lower than UI group: 9.5% (4/42) vs 70.0% (7/10) p < 0.001. Using ART, this rate was further reduced to 6.5% (2/31) and with bitherapy or triple therapy to 0% (0/18). Breast feeding, vaginal delivery, premature delivery with no clinical cause, premature rupture of membranes, rupture of membranes longer than 4 h and lack of ART, were significantly more common in the UI group, compared with KI group.

CONCLUSIONS

Vertical transmission in pregnant women with KI is significantly lower compared with UI. Risk factors increasing HIV perinatal infection are: breast feeding, lack of ART, vaginal delivery, premature rupture of membranes, rupture of membranes > 4 h and premature labor without a clinical cause.

Authors+Show Affiliations

Servicio y Departamento de Obstetricia, Ginecología y Neonatología, Hospital Clínico San Borja Arriarán, Facultad de Medicina, Universidad de Chile.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

spa

PubMed ID

12942591

Citation

Ovalle, Alfredo, et al. "[Human Immunodeficiency Virus Infection in Pregnant Women. the Importance of Recognizing the Infection During Pregnancy and Risk Factors for Perinatal Transmission]." Revista Medica De Chile, vol. 131, no. 6, 2003, pp. 633-40.
Ovalle A, Vizueta E, Casals A, et al. [Human immunodeficiency virus infection in pregnant women. The importance of recognizing the infection during pregnancy and risk factors for perinatal transmission]. Rev Med Chil. 2003;131(6):633-40.
Ovalle, A., Vizueta, E., Casals, A., Northland, R., González, R., & Labbe, E. (2003). [Human immunodeficiency virus infection in pregnant women. The importance of recognizing the infection during pregnancy and risk factors for perinatal transmission]. Revista Medica De Chile, 131(6), 633-40.
Ovalle A, et al. [Human Immunodeficiency Virus Infection in Pregnant Women. the Importance of Recognizing the Infection During Pregnancy and Risk Factors for Perinatal Transmission]. Rev Med Chil. 2003;131(6):633-40. PubMed PMID: 12942591.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Human immunodeficiency virus infection in pregnant women. The importance of recognizing the infection during pregnancy and risk factors for perinatal transmission]. AU - Ovalle,Alfredo, AU - Vizueta,Eloísa, AU - Casals,Alejandro, AU - Northland,Rebeca, AU - González,Reinaldo, AU - Labbe,Eduardo, PY - 2003/8/29/pubmed PY - 2003/11/13/medline PY - 2003/8/29/entrez SP - 633 EP - 40 JF - Revista medica de Chile JO - Rev Med Chil VL - 131 IS - 6 N2 - BACKGROUND: Using adequate infection control measures, the rate of vertical transmission of human immunodeficiency virus (HIV) during pregnancy, has been reduced to 3% in Chile. AIM: To determine vertical transmission rate and risk factors associated to perinatal infection in pregnant women with known (KI) and unknown HIV infection (UI). PATIENTS AND METHODS: HIV infected pregnant women whose deliveries were attended at the San Borja Arriaran Hospital were included. Antiretroviral therapy (ART) has been used since 1995 (Zidovudine 13 patients, biOtherapy 4 and triple therapy 14 patients). Newborns have received ART since 1995. Premature labor without evident cause, premature rupture of membranes, and rupture of membranes over 4 h before delivery were evaluated. Delivery was by elective cesarean section since 1993. Breast feeding was avoided. Pregnant women with UI (suspected disease after delivery due to child or mother pathology) did not received ART. Delivery and breast feeding were managed with common obstetrical-neonatal criteria. RESULTS: Fifty three HIV infected pregnant women were studied (43 with KI and 10 with UI). Four children (36.4%) from the KI group and seven (63.6%) from the UI group became infected. The global rate of vertical transmission among KI group was significantly lower than UI group: 9.5% (4/42) vs 70.0% (7/10) p < 0.001. Using ART, this rate was further reduced to 6.5% (2/31) and with bitherapy or triple therapy to 0% (0/18). Breast feeding, vaginal delivery, premature delivery with no clinical cause, premature rupture of membranes, rupture of membranes longer than 4 h and lack of ART, were significantly more common in the UI group, compared with KI group. CONCLUSIONS: Vertical transmission in pregnant women with KI is significantly lower compared with UI. Risk factors increasing HIV perinatal infection are: breast feeding, lack of ART, vaginal delivery, premature rupture of membranes, rupture of membranes > 4 h and premature labor without a clinical cause. SN - 0034-9887 UR - https://www.unboundmedicine.com/medline/citation/12942591/[Human_immunodeficiency_virus_infection_in_pregnant_women__The_importance_of_recognizing_the_infection_during_pregnancy_and_risk_factors_for_perinatal_transmission]_ L2 - https://www.diseaseinfosearch.org/result/5922 DB - PRIME DP - Unbound Medicine ER -