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Comparison of Streptococcus pneumoniae and Haemophilus influenzae susceptibilities from community-acquired respiratory tract infections and hospitalized patients with pneumonia: five-year results for the SENTRY Antimicrobial Surveillance Program.
Diagn Microbiol Infect Dis. 2003 Aug; 46(4):285-9.DM

Abstract

The SENTRY Antimicrobial Surveillance Program has been monitoring the activity of commonly prescribed and novel antimicrobial agents on a global scale from 1997 to the present. Specific objectives have documented the key resistance rates among pathogens from both patients hospitalized with pneumonia and those diagnosed with community-acquired pneumonia. Hemophilus influenzae and Streptococcus pneumoniae are common pathogens in both of these patient populations and the susceptibility profiles for these two species were compared to distinguish potential differences that may be evident in North American surveillance (1997-2001). A total of 6,515 isolates of S. pneumoniae and 6,726 H. influenzae strains were tested using reference broth microdilution methods at a monitoring center. Ampicillin resistance was approximately 25% among H. influenzae isolates and did not significantly differ between strains from community-acquired infections or hospitalized patients. beta-lactamase-negative ampicillin resistant strains and fluoroquinolone refractory strains were rare (0.3 and </= 0.2%, respectively) and the former only detected among hospitalized patients. Macrolide-resistant H. influenzae was most prevalent in hospitalized patients with pneumonia (24.4% for clarithromycin). In contrast, H. influenzae isolates from community-acquired infections were less susceptible (78.6-81.7%) to trimethoprim/sulfamethoxazole, but very susceptible to fluoroquinolones (99.9-100.0%). The community-acquired S. pneumoniae isolates were generally more resistant to penicillin (16.7%) and other beta-lactams compared to those from hospitalized patients (12.1%), and were also much more resistant to trimethoprim/sulfamethoxazole (25.0%) compared to inpatient isolates (6.7%). In contrast, isolates with reduced fluoroquinolone susceptibility or resistance were more common among hospitalized patients (ciprofloxacin resistance at 4.0%) and increased over the five monitored years. It is evident from this longitudinal study that some antimicrobial agents are becoming less efficacious against common respiratory tract pathogens depending on the clinical setting and surveillance of resistance appears to be a prudent practice.

Authors+Show Affiliations

The JONES Group/JMI Laboratories, North Liberty, IA, USA. kelley-gordon@jmilabs.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12944021

Citation

Gordon, Kelley A., et al. "Comparison of Streptococcus Pneumoniae and Haemophilus Influenzae Susceptibilities From Community-acquired Respiratory Tract Infections and Hospitalized Patients With Pneumonia: Five-year Results for the SENTRY Antimicrobial Surveillance Program." Diagnostic Microbiology and Infectious Disease, vol. 46, no. 4, 2003, pp. 285-9.
Gordon KA, Biedenbach DJ, Jones RN. Comparison of Streptococcus pneumoniae and Haemophilus influenzae susceptibilities from community-acquired respiratory tract infections and hospitalized patients with pneumonia: five-year results for the SENTRY Antimicrobial Surveillance Program. Diagn Microbiol Infect Dis. 2003;46(4):285-9.
Gordon, K. A., Biedenbach, D. J., & Jones, R. N. (2003). Comparison of Streptococcus pneumoniae and Haemophilus influenzae susceptibilities from community-acquired respiratory tract infections and hospitalized patients with pneumonia: five-year results for the SENTRY Antimicrobial Surveillance Program. Diagnostic Microbiology and Infectious Disease, 46(4), 285-9.
Gordon KA, Biedenbach DJ, Jones RN. Comparison of Streptococcus Pneumoniae and Haemophilus Influenzae Susceptibilities From Community-acquired Respiratory Tract Infections and Hospitalized Patients With Pneumonia: Five-year Results for the SENTRY Antimicrobial Surveillance Program. Diagn Microbiol Infect Dis. 2003;46(4):285-9. PubMed PMID: 12944021.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of Streptococcus pneumoniae and Haemophilus influenzae susceptibilities from community-acquired respiratory tract infections and hospitalized patients with pneumonia: five-year results for the SENTRY Antimicrobial Surveillance Program. AU - Gordon,Kelley A, AU - Biedenbach,Douglas J, AU - Jones,Ronald N, PY - 2003/8/29/pubmed PY - 2003/10/24/medline PY - 2003/8/29/entrez SP - 285 EP - 9 JF - Diagnostic microbiology and infectious disease JO - Diagn Microbiol Infect Dis VL - 46 IS - 4 N2 - The SENTRY Antimicrobial Surveillance Program has been monitoring the activity of commonly prescribed and novel antimicrobial agents on a global scale from 1997 to the present. Specific objectives have documented the key resistance rates among pathogens from both patients hospitalized with pneumonia and those diagnosed with community-acquired pneumonia. Hemophilus influenzae and Streptococcus pneumoniae are common pathogens in both of these patient populations and the susceptibility profiles for these two species were compared to distinguish potential differences that may be evident in North American surveillance (1997-2001). A total of 6,515 isolates of S. pneumoniae and 6,726 H. influenzae strains were tested using reference broth microdilution methods at a monitoring center. Ampicillin resistance was approximately 25% among H. influenzae isolates and did not significantly differ between strains from community-acquired infections or hospitalized patients. beta-lactamase-negative ampicillin resistant strains and fluoroquinolone refractory strains were rare (0.3 and </= 0.2%, respectively) and the former only detected among hospitalized patients. Macrolide-resistant H. influenzae was most prevalent in hospitalized patients with pneumonia (24.4% for clarithromycin). In contrast, H. influenzae isolates from community-acquired infections were less susceptible (78.6-81.7%) to trimethoprim/sulfamethoxazole, but very susceptible to fluoroquinolones (99.9-100.0%). The community-acquired S. pneumoniae isolates were generally more resistant to penicillin (16.7%) and other beta-lactams compared to those from hospitalized patients (12.1%), and were also much more resistant to trimethoprim/sulfamethoxazole (25.0%) compared to inpatient isolates (6.7%). In contrast, isolates with reduced fluoroquinolone susceptibility or resistance were more common among hospitalized patients (ciprofloxacin resistance at 4.0%) and increased over the five monitored years. It is evident from this longitudinal study that some antimicrobial agents are becoming less efficacious against common respiratory tract pathogens depending on the clinical setting and surveillance of resistance appears to be a prudent practice. SN - 0732-8893 UR - https://www.unboundmedicine.com/medline/citation/12944021/Comparison_of_Streptococcus_pneumoniae_and_Haemophilus_influenzae_susceptibilities_from_community_acquired_respiratory_tract_infections_and_hospitalized_patients_with_pneumonia:_five_year_results_for_the_SENTRY_Antimicrobial_Surveillance_Program_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0732889303000877 DB - PRIME DP - Unbound Medicine ER -