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Improved solubility and in vitro dissolution of Ibuprofen from poloxamer gel using eutectic mixture with menthol.
Drug Deliv. 2003 Jul-Sep; 10(3):179-83.DD

Abstract

To improve the solubility and in vitro dissolution of poorly water-soluble ibuprofen with poloxamer and menthol, the effects of menthol and poloxamer 188 on the aqueous solubility of ibuprofen were investigated. The dissolution study of ibuprofen delivered by poloxamer gels composed of poloxamer 188 and menthol were performed. In the absence of poloxamer, the solubility of ibuprofen increased until the ratio of menthol to ibuprofen increased from 0:10 to 4:6, followed by an abrupt decrease in solubility above the ratio of 4:6, indicating that 4 parts of ibuprofen formed eutectic mixture with 6 parts of menthol. In the presence of poloxamer 188, the solutions with the same ratio of menthol to ibuprofen showed abrupt increase in the solubility of ibuprofen. Furthermore, the solution with ratio of 4:6 showed more than 2.5- and 6-fold increase in the solubility of ibuprofen compared with that without poloxamer and that without menthol, respectively. The poloxamer gel with menthol/ibuprofen ratio of 1:9 and higher than 15% poloxamer 188 showed the maximum solubility of ibuprofen, 1.2 mg/ml. Menthol improved the dissolution rates of ibuprofen from poloxamer gels. Dissolution mechanism showed that the dissolution rate of ibuprofen from the poloxamer gels without menthol was independent of the time, but the drug might be dissolved from the poloxamer gels with menthol by Fickian diffusion. Thus, the poloxamer gels developed using eutectic mixture with menthol, which gave the improved solubility and dissolution of drug, are potential candidates for ibuprofen-loaded transdermal and rectal delivery system.

Authors+Show Affiliations

College of Pharmacy, Yeungnam University, Gyongsan, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12944138

Citation

Yong, Chul Soon, et al. "Improved Solubility and in Vitro Dissolution of Ibuprofen From Poloxamer Gel Using Eutectic Mixture With Menthol." Drug Delivery, vol. 10, no. 3, 2003, pp. 179-83.
Yong CS, Jung SH, Rhee JD, et al. Improved solubility and in vitro dissolution of Ibuprofen from poloxamer gel using eutectic mixture with menthol. Drug Deliv. 2003;10(3):179-83.
Yong, C. S., Jung, S. H., Rhee, J. D., Choi, H. G., Lee, B. J., Kim, D. C., Choi, Y. W., & Kim, C. K. (2003). Improved solubility and in vitro dissolution of Ibuprofen from poloxamer gel using eutectic mixture with menthol. Drug Delivery, 10(3), 179-83.
Yong CS, et al. Improved Solubility and in Vitro Dissolution of Ibuprofen From Poloxamer Gel Using Eutectic Mixture With Menthol. Drug Deliv. 2003 Jul-Sep;10(3):179-83. PubMed PMID: 12944138.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Improved solubility and in vitro dissolution of Ibuprofen from poloxamer gel using eutectic mixture with menthol. AU - Yong,Chul Soon, AU - Jung,Se Hyun, AU - Rhee,Jong-Dal, AU - Choi,Han-Gon, AU - Lee,Beom-Jin, AU - Kim,Dong-Chool, AU - Choi,Young Wook, AU - Kim,Chong-Kook, PY - 2003/8/29/pubmed PY - 2004/5/22/medline PY - 2003/8/29/entrez SP - 179 EP - 83 JF - Drug delivery JO - Drug Deliv VL - 10 IS - 3 N2 - To improve the solubility and in vitro dissolution of poorly water-soluble ibuprofen with poloxamer and menthol, the effects of menthol and poloxamer 188 on the aqueous solubility of ibuprofen were investigated. The dissolution study of ibuprofen delivered by poloxamer gels composed of poloxamer 188 and menthol were performed. In the absence of poloxamer, the solubility of ibuprofen increased until the ratio of menthol to ibuprofen increased from 0:10 to 4:6, followed by an abrupt decrease in solubility above the ratio of 4:6, indicating that 4 parts of ibuprofen formed eutectic mixture with 6 parts of menthol. In the presence of poloxamer 188, the solutions with the same ratio of menthol to ibuprofen showed abrupt increase in the solubility of ibuprofen. Furthermore, the solution with ratio of 4:6 showed more than 2.5- and 6-fold increase in the solubility of ibuprofen compared with that without poloxamer and that without menthol, respectively. The poloxamer gel with menthol/ibuprofen ratio of 1:9 and higher than 15% poloxamer 188 showed the maximum solubility of ibuprofen, 1.2 mg/ml. Menthol improved the dissolution rates of ibuprofen from poloxamer gels. Dissolution mechanism showed that the dissolution rate of ibuprofen from the poloxamer gels without menthol was independent of the time, but the drug might be dissolved from the poloxamer gels with menthol by Fickian diffusion. Thus, the poloxamer gels developed using eutectic mixture with menthol, which gave the improved solubility and dissolution of drug, are potential candidates for ibuprofen-loaded transdermal and rectal delivery system. SN - 1071-7544 UR - https://www.unboundmedicine.com/medline/citation/12944138/Improved_solubility_and_in_vitro_dissolution_of_Ibuprofen_from_poloxamer_gel_using_eutectic_mixture_with_menthol_ DB - PRIME DP - Unbound Medicine ER -