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The frequency of vitamin D deficiency in adults with Crohn's disease.
Can J Gastroenterol 2003; 17(8):473-8CJ

Abstract

BACKGROUND

Vitamin D deficiency is a putative, pathogenic cofactor in the increase in osteopenia and osteoporosis seen in patients with Crohn's disease.

OBJECTIVE

To determine the frequency of low serum 25-hydroxy-vitamin D3 (25-OHD) levels and the associated alterations in bone mineral density in a cohort of adults with Crohn's disease.

METHODS

25-OHD levels were determined in 242 consecutive patients with Crohn's disease seen in two tertiary inflammatory bowel disease referral centres. Bone mineral density was assessed by dual energy x-ray absorptiometry.

RESULTS

Nineteen (8%) patients exhibited vitamin D deficiency (25-OHD less than 25 nmol/L) and 52 (22%) patients exhibited vitamin D insufficiency (25-OHD less than 40 nmol/L). Mean T-scores at the lumbar spine, femoral neck, total hip and ultradistal radius in the group with low 25-OHD did not differ from those of the normal 25-OHD group. Serum alkaline phosphatase and parathyroid hormone levels were higher in the low 25-OHD group than in the normal group. Decreased red blood cell (RBC) folate predicted low 25-OHD in male patients, while smoking, RBC folate and serum iron predicted low 25-OHD in female patients. The rate of low 25-OHD deficiency in the winter was significantly higher than that in the summer (11.9% versus 2.8%, respectively).

CONCLUSION

Vitamin D-deficient Crohn's disease patients exhibit biochemical evidence of metabolic bone disease, without detectable differences in bone mineral density. Sunlight exposure, nutrition and smoking status were predictors of vitamin D deficiency in this patient cohort.

Authors+Show Affiliations

Department of Medicine, University of Alberta, Edmonton.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12945007

Citation

Siffledeen, Jesse S., et al. "The Frequency of Vitamin D Deficiency in Adults With Crohn's Disease." Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie, vol. 17, no. 8, 2003, pp. 473-8.
Siffledeen JS, Siminoski K, Steinhart H, et al. The frequency of vitamin D deficiency in adults with Crohn's disease. Can J Gastroenterol. 2003;17(8):473-8.
Siffledeen, J. S., Siminoski, K., Steinhart, H., Greenberg, G., & Fedorak, R. N. (2003). The frequency of vitamin D deficiency in adults with Crohn's disease. Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie, 17(8), pp. 473-8.
Siffledeen JS, et al. The Frequency of Vitamin D Deficiency in Adults With Crohn's Disease. Can J Gastroenterol. 2003;17(8):473-8. PubMed PMID: 12945007.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The frequency of vitamin D deficiency in adults with Crohn's disease. AU - Siffledeen,Jesse S, AU - Siminoski,Kerry, AU - Steinhart,Hillary, AU - Greenberg,Gordon, AU - Fedorak,Richard N, PY - 2003/8/29/pubmed PY - 2003/12/17/medline PY - 2003/8/29/entrez SP - 473 EP - 8 JF - Canadian journal of gastroenterology = Journal canadien de gastroenterologie JO - Can. J. Gastroenterol. VL - 17 IS - 8 N2 - BACKGROUND: Vitamin D deficiency is a putative, pathogenic cofactor in the increase in osteopenia and osteoporosis seen in patients with Crohn's disease. OBJECTIVE: To determine the frequency of low serum 25-hydroxy-vitamin D3 (25-OHD) levels and the associated alterations in bone mineral density in a cohort of adults with Crohn's disease. METHODS: 25-OHD levels were determined in 242 consecutive patients with Crohn's disease seen in two tertiary inflammatory bowel disease referral centres. Bone mineral density was assessed by dual energy x-ray absorptiometry. RESULTS: Nineteen (8%) patients exhibited vitamin D deficiency (25-OHD less than 25 nmol/L) and 52 (22%) patients exhibited vitamin D insufficiency (25-OHD less than 40 nmol/L). Mean T-scores at the lumbar spine, femoral neck, total hip and ultradistal radius in the group with low 25-OHD did not differ from those of the normal 25-OHD group. Serum alkaline phosphatase and parathyroid hormone levels were higher in the low 25-OHD group than in the normal group. Decreased red blood cell (RBC) folate predicted low 25-OHD in male patients, while smoking, RBC folate and serum iron predicted low 25-OHD in female patients. The rate of low 25-OHD deficiency in the winter was significantly higher than that in the summer (11.9% versus 2.8%, respectively). CONCLUSION: Vitamin D-deficient Crohn's disease patients exhibit biochemical evidence of metabolic bone disease, without detectable differences in bone mineral density. Sunlight exposure, nutrition and smoking status were predictors of vitamin D deficiency in this patient cohort. SN - 0835-7900 UR - https://www.unboundmedicine.com/medline/citation/12945007/The_frequency_of_vitamin_D_deficiency_in_adults_with_Crohn's_disease_ L2 - http://www.diseaseinfosearch.org/result/2013 DB - PRIME DP - Unbound Medicine ER -