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The genetics of pancreatic cancer.

Abstract

The genetic basis for invasive and preoneoplastic neoplasms of the exocrine and endocrine pancreas has been the subject of a number of investigations in recent years. The purpose of this paper was to briefly review and summarize the pertinent findings. High frequency changes associated with pancreatic adenocarcinomas include mutations of the k-ras oncogene, and inactivating alterations of the p53, p16, and DPC4 tumor suppressor genes. Hereditary syndromes that have a known predisposition for pancreatic adenocarcinoma development include hereditary pancreatitis, familial atypical multiple mole melanoma (FAMM) syndrome, Peutz-Jeghers syndrome, familial breast cancer (BRCA-2), hereditary nonpolyposis colorectal cancer syndrome (HNPCC), and Li-Fraumeni syndrome. The underlying genetic defects have been identified and are currently being studied. Germline mutations of the men-1 gene are responsible for the MEN-1 syndrome, known to be associated with pancreatic endocrine tumors. It appears that somatic mutations of the gene are present in at least a subset of sporadic tumors. In addition, alterations in the Rb/p16 pathway appear to be commonly associated with pancreatic endocrine tumors. Further characterization of pancreatic tumors will result in a better understanding of the cellular pathways involved in pancreatic tumorigenesis and holds promise to identify targets for novel diagnostic and therapeutic strategies.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Surgery, Ohio State University Medical Center and Ohio State University Comprehensive Cancer Center, N711 Doan Hall, 410 West 10th Ave., Columbus, OH 43210, USA.

    Source

    American journal of surgery 186:3 2003 Sep pg 279-86

    MeSH

    Adenocarcinoma
    Female
    Genes, Tumor Suppressor
    Genes, ras
    Humans
    Male
    Multiple Endocrine Neoplasia Type 1
    Mutation
    Neoplastic Syndromes, Hereditary
    Pancreatic Neoplasms

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    12946833

    Citation

    Cowgill, Sarah M., and Peter Muscarella. "The Genetics of Pancreatic Cancer." American Journal of Surgery, vol. 186, no. 3, 2003, pp. 279-86.
    Cowgill SM, Muscarella P. The genetics of pancreatic cancer. Am J Surg. 2003;186(3):279-86.
    Cowgill, S. M., & Muscarella, P. (2003). The genetics of pancreatic cancer. American Journal of Surgery, 186(3), pp. 279-86.
    Cowgill SM, Muscarella P. The Genetics of Pancreatic Cancer. Am J Surg. 2003;186(3):279-86. PubMed PMID: 12946833.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The genetics of pancreatic cancer. AU - Cowgill,Sarah M, AU - Muscarella,Peter, PY - 2003/8/30/pubmed PY - 2003/9/26/medline PY - 2003/8/30/entrez SP - 279 EP - 86 JF - American journal of surgery JO - Am. J. Surg. VL - 186 IS - 3 N2 - The genetic basis for invasive and preoneoplastic neoplasms of the exocrine and endocrine pancreas has been the subject of a number of investigations in recent years. The purpose of this paper was to briefly review and summarize the pertinent findings. High frequency changes associated with pancreatic adenocarcinomas include mutations of the k-ras oncogene, and inactivating alterations of the p53, p16, and DPC4 tumor suppressor genes. Hereditary syndromes that have a known predisposition for pancreatic adenocarcinoma development include hereditary pancreatitis, familial atypical multiple mole melanoma (FAMM) syndrome, Peutz-Jeghers syndrome, familial breast cancer (BRCA-2), hereditary nonpolyposis colorectal cancer syndrome (HNPCC), and Li-Fraumeni syndrome. The underlying genetic defects have been identified and are currently being studied. Germline mutations of the men-1 gene are responsible for the MEN-1 syndrome, known to be associated with pancreatic endocrine tumors. It appears that somatic mutations of the gene are present in at least a subset of sporadic tumors. In addition, alterations in the Rb/p16 pathway appear to be commonly associated with pancreatic endocrine tumors. Further characterization of pancreatic tumors will result in a better understanding of the cellular pathways involved in pancreatic tumorigenesis and holds promise to identify targets for novel diagnostic and therapeutic strategies. SN - 0002-9610 UR - https://www.unboundmedicine.com/medline/citation/12946833/The_genetics_of_pancreatic_cancer_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002961003002265 DB - PRIME DP - Unbound Medicine ER -