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The effect of naloxone on restraint-induced antinociception in mice.
Methods Find Exp Clin Pharmacol. 1992 Nov; 14(9):695-700.MF

Abstract

Restraint for a period from 15-60 min induced significant antinociceptive effect in both male and female mice. The restraint animals all showed an increase in response time to the hot plate test at 55 degrees C. The antinociceptive activity was still apparent one hour after restraint. In the male animals, prior administration of naloxone s.c. 15 min before restraint for 60 min did not affect the degree of antinociceptive activity induced by restraint. In addition, naloxone administered s.c. immediately after restraint for 60 min also did not affect the degree of antinociceptive activity in male mice. These findings indicate that in male animals the endogenous opioid mechanism is most likely not involved in the restraint-induced antinociception. However, for the female mice naloxone administered s.c. either before or immediately after restraint for 60 min dose-dependently suppressed the antinociceptive activity induced by restraint. It is concluded that restraint can induce antinociceptive activity in mice; however, different mechanisms may be involved in the antinociception observed. In male mice the endogenous opioid systems do not seem to play a significant role in restraint-induced antinociception, while for female animals blockade of opioid receptors would greatly diminish the antinociception observed after restraint.

Authors+Show Affiliations

School of Pharmacy, University of Portsmouth, England.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1294857

Citation

Wong, C L.. "The Effect of Naloxone On Restraint-induced Antinociception in Mice." Methods and Findings in Experimental and Clinical Pharmacology, vol. 14, no. 9, 1992, pp. 695-700.
Wong CL. The effect of naloxone on restraint-induced antinociception in mice. Methods Find Exp Clin Pharmacol. 1992;14(9):695-700.
Wong, C. L. (1992). The effect of naloxone on restraint-induced antinociception in mice. Methods and Findings in Experimental and Clinical Pharmacology, 14(9), 695-700.
Wong CL. The Effect of Naloxone On Restraint-induced Antinociception in Mice. Methods Find Exp Clin Pharmacol. 1992;14(9):695-700. PubMed PMID: 1294857.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of naloxone on restraint-induced antinociception in mice. A1 - Wong,C L, PY - 1992/11/1/pubmed PY - 1992/11/1/medline PY - 1992/11/1/entrez SP - 695 EP - 700 JF - Methods and findings in experimental and clinical pharmacology JO - Methods Find Exp Clin Pharmacol VL - 14 IS - 9 N2 - Restraint for a period from 15-60 min induced significant antinociceptive effect in both male and female mice. The restraint animals all showed an increase in response time to the hot plate test at 55 degrees C. The antinociceptive activity was still apparent one hour after restraint. In the male animals, prior administration of naloxone s.c. 15 min before restraint for 60 min did not affect the degree of antinociceptive activity induced by restraint. In addition, naloxone administered s.c. immediately after restraint for 60 min also did not affect the degree of antinociceptive activity in male mice. These findings indicate that in male animals the endogenous opioid mechanism is most likely not involved in the restraint-induced antinociception. However, for the female mice naloxone administered s.c. either before or immediately after restraint for 60 min dose-dependently suppressed the antinociceptive activity induced by restraint. It is concluded that restraint can induce antinociceptive activity in mice; however, different mechanisms may be involved in the antinociception observed. In male mice the endogenous opioid systems do not seem to play a significant role in restraint-induced antinociception, while for female animals blockade of opioid receptors would greatly diminish the antinociception observed after restraint. SN - 0379-0355 UR - https://www.unboundmedicine.com/medline/citation/1294857/The_effect_of_naloxone_on_restraint_induced_antinociception_in_mice_ L2 - https://medlineplus.gov/stress.html DB - PRIME DP - Unbound Medicine ER -