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Epileptic seizures and syndromes in twins: the importance of genetic factors.
Epilepsy Res. 2003 Jun-Jul; 55(1-2):137-46.ER

Abstract

The role of genetic factors in the occurrence of epilepsy syndromes was studied in twins recruited from the population-based Danish Twin Registry. A total of 34,076 twins were screened for epilepsy. Cases were confirmed and classified by two neurologists according to the classification systems of the International League Against Epilepsy (ILAE). A total of 214 twin pairs with epileptic seizures and 190 pairs with epilepsy were ascertained. Significantly higher concordance rates were found for monozygotic (MZ) compared to dizygotic (DZ) twins for both epileptic seizures (0.56 for MZ and 0.21 for DZ pairs, P<0.001) and for epilepsy (0.49 for MZ and 0.16 for DZ pairs, P<0.001). Concordance rates were also higher for MZ twins compared to DZ twins for both generalized epilepsy (0.65 for MZ and 0.12 for DZ) and for localization-related epilepsy (0.30 for MZ and 0.10 for DZ). In twin pairs where both members had seizures, 83% of MZ and 65% of DZ pairs had the same major epilepsy syndrome. Genetic factors were found to account for 80% of the liability to both epileptic seizures and epilepsy. In conclusion, analysis of this neurologist-verified epilepsy twin data set has confirmed that genetic factors have a substantial impact on the etiology of epileptic seizures as well as on the occurrence of both generalized and partial epilepsies.

Authors+Show Affiliations

Department of Neurology, Odense University Hospital, Sdr. Boulevard 29, DK-5000 Odense C, Denmark. mjk@dadlnet.dkNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Twin Study

Language

eng

PubMed ID

12948623

Citation

Kjeldsen, Marianne Juel, et al. "Epileptic Seizures and Syndromes in Twins: the Importance of Genetic Factors." Epilepsy Research, vol. 55, no. 1-2, 2003, pp. 137-46.
Kjeldsen MJ, Corey LA, Christensen K, et al. Epileptic seizures and syndromes in twins: the importance of genetic factors. Epilepsy Res. 2003;55(1-2):137-46.
Kjeldsen, M. J., Corey, L. A., Christensen, K., & Friis, M. L. (2003). Epileptic seizures and syndromes in twins: the importance of genetic factors. Epilepsy Research, 55(1-2), 137-46.
Kjeldsen MJ, et al. Epileptic Seizures and Syndromes in Twins: the Importance of Genetic Factors. Epilepsy Res. 2003 Jun-Jul;55(1-2):137-46. PubMed PMID: 12948623.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epileptic seizures and syndromes in twins: the importance of genetic factors. AU - Kjeldsen,Marianne Juel, AU - Corey,Linda A, AU - Christensen,Kaare, AU - Friis,Mogens Laue, PY - 2003/9/2/pubmed PY - 2003/10/24/medline PY - 2003/9/2/entrez SP - 137 EP - 46 JF - Epilepsy research JO - Epilepsy Res. VL - 55 IS - 1-2 N2 - The role of genetic factors in the occurrence of epilepsy syndromes was studied in twins recruited from the population-based Danish Twin Registry. A total of 34,076 twins were screened for epilepsy. Cases were confirmed and classified by two neurologists according to the classification systems of the International League Against Epilepsy (ILAE). A total of 214 twin pairs with epileptic seizures and 190 pairs with epilepsy were ascertained. Significantly higher concordance rates were found for monozygotic (MZ) compared to dizygotic (DZ) twins for both epileptic seizures (0.56 for MZ and 0.21 for DZ pairs, P<0.001) and for epilepsy (0.49 for MZ and 0.16 for DZ pairs, P<0.001). Concordance rates were also higher for MZ twins compared to DZ twins for both generalized epilepsy (0.65 for MZ and 0.12 for DZ) and for localization-related epilepsy (0.30 for MZ and 0.10 for DZ). In twin pairs where both members had seizures, 83% of MZ and 65% of DZ pairs had the same major epilepsy syndrome. Genetic factors were found to account for 80% of the liability to both epileptic seizures and epilepsy. In conclusion, analysis of this neurologist-verified epilepsy twin data set has confirmed that genetic factors have a substantial impact on the etiology of epileptic seizures as well as on the occurrence of both generalized and partial epilepsies. SN - 0920-1211 UR - https://www.unboundmedicine.com/medline/citation/12948623/Epileptic_seizures_and_syndromes_in_twins:_the_importance_of_genetic_factors_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0920121103001177 DB - PRIME DP - Unbound Medicine ER -