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Physiological validation of the concept of glycemic load in lean young adults.
J Nutr. 2003 Sep; 133(9):2728-32.JN

Abstract

Dietary glycemic load, the mathematical product of the glycemic index (GI) of a food and its carbohydrate content, has been proposed as an indicator of the glucose response and insulin demand induced by a serving of food. To validate this concept in vivo, we tested the hypotheses that 1). portions of different foods with the same glycemic load produce similar glycemic responses; and 2). stepwise increases in glycemic load for a range of foods produce proportional increases in glycemia and insulinemia. In the first study, 10 healthy subjects consumed 10 different foods in random order in amounts calculated to have the same glycemic load as one slice of white bread. Capillary blood samples were taken at regular intervals over the next 2 h. The glycemic response as determined by area under the curve was not different from that of white bread for nine foods. However, lentils produced lower than predicted responses (P < 0.05). In the second study, another group of subjects was tested to determine the effects of increasing glycemic load using a balanced 5 x 5 Greco-Latin square design balanced for four variables: subject, dose, food and order. Two sets of five foods were consumed at five different glycemic loads (doses) equivalent to one, two, three, four and six slices of bread. Stepwise increases in glycemic load produced significant and predictable increases in both glycemia (P < 0.001) and insulinemia (P < 0.001). These findings support the concept of dietary glycemic load as a measure of overall glycemic response and insulin demand.

Authors+Show Affiliations

Brand-Miller JC
Human Nutrition Unit, School of Molecular and Microbial Biosciences, University of Sydney, Sydney, NSW, Australia. j.brandmiller@staff.usyd.edu.au
Thomas M
No affiliation info available
Swan V
No affiliation info available
Ahmad ZI
No affiliation info available
Petocz P
No affiliation info available
Colagiuri S
No affiliation info available

MeSH

AdultArea Under CurveBlood GlucoseBreadDietary CarbohydratesDose-Response Relationship, DrugFabaceaeFemaleGlycemic IndexHumansInsulinMalePostprandial PeriodReference ValuesThinness

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Validation Study

Language

eng

PubMed ID

12949357

Citation

Brand-Miller, J C., et al. "Physiological Validation of the Concept of Glycemic Load in Lean Young Adults." The Journal of Nutrition, vol. 133, no. 9, 2003, pp. 2728-32.
Brand-Miller JC, Thomas M, Swan V, et al. Physiological validation of the concept of glycemic load in lean young adults. J Nutr. 2003;133(9):2728-32.
Brand-Miller, J. C., Thomas, M., Swan, V., Ahmad, Z. I., Petocz, P., & Colagiuri, S. (2003). Physiological validation of the concept of glycemic load in lean young adults. The Journal of Nutrition, 133(9), 2728-32.
Brand-Miller JC, et al. Physiological Validation of the Concept of Glycemic Load in Lean Young Adults. J Nutr. 2003;133(9):2728-32. PubMed PMID: 12949357.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Physiological validation of the concept of glycemic load in lean young adults. AU - Brand-Miller,J C, AU - Thomas,M, AU - Swan,V, AU - Ahmad,Z I, AU - Petocz,P, AU - Colagiuri,S, PY - 2003/9/2/pubmed PY - 2003/10/29/medline PY - 2003/9/2/entrez SP - 2728 EP - 32 JF - The Journal of nutrition JO - J Nutr VL - 133 IS - 9 N2 - Dietary glycemic load, the mathematical product of the glycemic index (GI) of a food and its carbohydrate content, has been proposed as an indicator of the glucose response and insulin demand induced by a serving of food. To validate this concept in vivo, we tested the hypotheses that 1). portions of different foods with the same glycemic load produce similar glycemic responses; and 2). stepwise increases in glycemic load for a range of foods produce proportional increases in glycemia and insulinemia. In the first study, 10 healthy subjects consumed 10 different foods in random order in amounts calculated to have the same glycemic load as one slice of white bread. Capillary blood samples were taken at regular intervals over the next 2 h. The glycemic response as determined by area under the curve was not different from that of white bread for nine foods. However, lentils produced lower than predicted responses (P < 0.05). In the second study, another group of subjects was tested to determine the effects of increasing glycemic load using a balanced 5 x 5 Greco-Latin square design balanced for four variables: subject, dose, food and order. Two sets of five foods were consumed at five different glycemic loads (doses) equivalent to one, two, three, four and six slices of bread. Stepwise increases in glycemic load produced significant and predictable increases in both glycemia (P < 0.001) and insulinemia (P < 0.001). These findings support the concept of dietary glycemic load as a measure of overall glycemic response and insulin demand. SN - 0022-3166 UR - https://www.unboundmedicine.com/medline/citation/12949357/Physiological_validation_of_the_concept_of_glycemic_load_in_lean_young_adults_ DB - PRIME DP - Unbound Medicine ER -