Tags

Type your tag names separated by a space and hit enter

Osteogenesis imperfecta in two litters of dachshunds.
Vet Pathol. 2003 Sep; 40(5):530-9.VP

Abstract

A clinical, morphologic, ultrastructural, and genetic study was performed on five rough-coated dachshund semisiblings with osteogenesis imperfecta (OI). Clinical signs consisted of pain, spontaneous bone and teeth fractures, joint hyperlaxity, and reduced bone density on radiography. Primary teeth were extremely thin-walled and brittle. The hallmark of the disease was a severe osteopenia characterized by impairment of lamellar bone formation in the long bones, skull, and vertebral column. No deformity or dwarfism was present. The columns of chondrocytes and primary trabeculae in the epiphyses and metaphyses were histologically normal. An abrupt failure of secondary spongiosa and lamellar bone formation was evident in the medullary and cortical zones in all animals. The few existing trabeculae consisted of woven bone. There was no increase in the number and size of osteoclasts or lacunae. In the teeth, the dentine layers were thin and lacked a tubular pattern. Ultrastructurally, osteoid apposition on bone surfaces was reduced, and small numbers of large cytoplasmic vacuoles were present in a few osteoblasts. Molecular analyses of the collagen type I-encoding genes COL1A1 and COL1A2 revealed several nucleotide differences compared with the published canine sequences but were not significant for OI. Therefore, OI in these Dachshund litters was characterized by a severe, generalized osteopenia and dentinopenia. This pattern of reduced bone formation is suggestive of defective production of collagen type I.

Authors+Show Affiliations

Institut für Pathologie der Tierärztlichen Hochschule Hannover, Bünteweg 17, 30559 Hannover, Germany. frank.seeliger@tiho-hannover.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12949410

Citation

Seeliger, F, et al. "Osteogenesis Imperfecta in Two Litters of Dachshunds." Veterinary Pathology, vol. 40, no. 5, 2003, pp. 530-9.
Seeliger F, Leeb T, Peters M, et al. Osteogenesis imperfecta in two litters of dachshunds. Vet Pathol. 2003;40(5):530-9.
Seeliger, F., Leeb, T., Peters, M., Brugmann, M., Fehr, M., & Hewicker-Trautwein, M. (2003). Osteogenesis imperfecta in two litters of dachshunds. Veterinary Pathology, 40(5), 530-9.
Seeliger F, et al. Osteogenesis Imperfecta in Two Litters of Dachshunds. Vet Pathol. 2003;40(5):530-9. PubMed PMID: 12949410.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Osteogenesis imperfecta in two litters of dachshunds. AU - Seeliger,F, AU - Leeb,T, AU - Peters,M, AU - Brugmann,M, AU - Fehr,M, AU - Hewicker-Trautwein,M, PY - 2003/9/2/pubmed PY - 2003/12/13/medline PY - 2003/9/2/entrez SP - 530 EP - 9 JF - Veterinary pathology JO - Vet Pathol VL - 40 IS - 5 N2 - A clinical, morphologic, ultrastructural, and genetic study was performed on five rough-coated dachshund semisiblings with osteogenesis imperfecta (OI). Clinical signs consisted of pain, spontaneous bone and teeth fractures, joint hyperlaxity, and reduced bone density on radiography. Primary teeth were extremely thin-walled and brittle. The hallmark of the disease was a severe osteopenia characterized by impairment of lamellar bone formation in the long bones, skull, and vertebral column. No deformity or dwarfism was present. The columns of chondrocytes and primary trabeculae in the epiphyses and metaphyses were histologically normal. An abrupt failure of secondary spongiosa and lamellar bone formation was evident in the medullary and cortical zones in all animals. The few existing trabeculae consisted of woven bone. There was no increase in the number and size of osteoclasts or lacunae. In the teeth, the dentine layers were thin and lacked a tubular pattern. Ultrastructurally, osteoid apposition on bone surfaces was reduced, and small numbers of large cytoplasmic vacuoles were present in a few osteoblasts. Molecular analyses of the collagen type I-encoding genes COL1A1 and COL1A2 revealed several nucleotide differences compared with the published canine sequences but were not significant for OI. Therefore, OI in these Dachshund litters was characterized by a severe, generalized osteopenia and dentinopenia. This pattern of reduced bone formation is suggestive of defective production of collagen type I. SN - 0300-9858 UR - https://www.unboundmedicine.com/medline/citation/12949410/Osteogenesis_imperfecta_in_two_litters_of_dachshunds_ L2 - https://journals.sagepub.com/doi/10.1354/vp.40-5-530?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -