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[Sublingual administration of apomorphine in the treatment of motor fluctuations in Parkinson disease].
Rev Neurol (Paris). 1992; 148(10):610-4.RN

Abstract

Apomorphine, a mixed dopaminergic agonist was given sublingually to 12 patients with Parkinson's disease disabled by severe on-off fluctuations. The patient's mean age was 57 years and the duration of Parkinson's disease was 12 years. All patients were also given domperidone (60 mg/day). Apomorphine was administered as soon as the off periods appeared. On periods were observed in 11 patients, with a mean apomorphine dose of 40 mg for each administration (extremes values: 20-60 mg). One patient had no motor benefit after an apomorphine dose of 120 mg. The mean duration of daily off periods was reduced by 64 per cent in 11 patients, for a mean duration of 8 months (extremes values: 2-12 months). Four patients developed stomatitis or gingival edema and stopped treatment. This pilot study shows that sublingual apomorphine, during a mean period of 8 months, significantly decreases off periods in parkinsonian patients. Others studies are necessary to confirm these results.

Authors+Show Affiliations

Service de Neurologie, Hôpital Fontmaure, Clermont-Ferrand.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

fre

PubMed ID

1295055

Citation

Durif, F, et al. "[Sublingual Administration of Apomorphine in the Treatment of Motor Fluctuations in Parkinson Disease]." Revue Neurologique, vol. 148, no. 10, 1992, pp. 610-4.
Durif F, Deffond D, Eschalier A, et al. [Sublingual administration of apomorphine in the treatment of motor fluctuations in Parkinson disease]. Rev Neurol (Paris). 1992;148(10):610-4.
Durif, F., Deffond, D., Eschalier, A., & Tournilhac, M. (1992). [Sublingual administration of apomorphine in the treatment of motor fluctuations in Parkinson disease]. Revue Neurologique, 148(10), 610-4.
Durif F, et al. [Sublingual Administration of Apomorphine in the Treatment of Motor Fluctuations in Parkinson Disease]. Rev Neurol (Paris). 1992;148(10):610-4. PubMed PMID: 1295055.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Sublingual administration of apomorphine in the treatment of motor fluctuations in Parkinson disease]. AU - Durif,F, AU - Deffond,D, AU - Eschalier,A, AU - Tournilhac,M, PY - 1992/1/1/pubmed PY - 1992/1/1/medline PY - 1992/1/1/entrez SP - 610 EP - 4 JF - Revue neurologique JO - Rev Neurol (Paris) VL - 148 IS - 10 N2 - Apomorphine, a mixed dopaminergic agonist was given sublingually to 12 patients with Parkinson's disease disabled by severe on-off fluctuations. The patient's mean age was 57 years and the duration of Parkinson's disease was 12 years. All patients were also given domperidone (60 mg/day). Apomorphine was administered as soon as the off periods appeared. On periods were observed in 11 patients, with a mean apomorphine dose of 40 mg for each administration (extremes values: 20-60 mg). One patient had no motor benefit after an apomorphine dose of 120 mg. The mean duration of daily off periods was reduced by 64 per cent in 11 patients, for a mean duration of 8 months (extremes values: 2-12 months). Four patients developed stomatitis or gingival edema and stopped treatment. This pilot study shows that sublingual apomorphine, during a mean period of 8 months, significantly decreases off periods in parkinsonian patients. Others studies are necessary to confirm these results. SN - 0035-3787 UR - https://www.unboundmedicine.com/medline/citation/1295055/[Sublingual_administration_of_apomorphine_in_the_treatment_of_motor_fluctuations_in_Parkinson_disease]_ L2 - http://www.diseaseinfosearch.org/result/5603 DB - PRIME DP - Unbound Medicine ER -