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Antioxidant and free radical scavenging activities of Terminalia chebula.

Abstract

Free radicals react with biological molecules and destroy the structure of cells, which eventually causes free-radical induced disease such as cancer, renal failure, aging, etc. In this study, 6 extracts and 4 pure compounds of Terminalia chebula RETZ. were investigated for anti-lipid peroxidation, anti-superoxide radical formation and free radical scavenging activities. The superoxide radical scavenging of the 4 pure compounds was further evaluated using electron spin resonance (ESR) spectrometry. The results showed that all tested extracts and pure compounds of T. chebula exhibited antioxidant activity at different magnitudes of potency. The antioxidant activity of each pure compound was derived from different pathways and was suggested to be specific.

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  • Authors+Show Affiliations

    ,

    Graduate Institute of Pharmaceutical Science, Kaohsiung Medical University, Taiwan.

    , , ,

    Source

    Biological & pharmaceutical bulletin 26:9 2003 Sep pg 1331-5

    MeSH

    Animals
    Antioxidants
    Electron Spin Resonance Spectroscopy
    Free Radical Scavengers
    In Vitro Techniques
    Lipid Peroxidation
    Male
    Microsomes, Liver
    Oxidation-Reduction
    Plant Extracts
    Rats
    Rats, Wistar
    Superoxide Dismutase
    Superoxides
    Terminalia

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    12951481

    Citation

    Cheng, Hua-Yew, et al. "Antioxidant and Free Radical Scavenging Activities of Terminalia Chebula." Biological & Pharmaceutical Bulletin, vol. 26, no. 9, 2003, pp. 1331-5.
    Cheng HY, Lin TC, Yu KH, et al. Antioxidant and free radical scavenging activities of Terminalia chebula. Biol Pharm Bull. 2003;26(9):1331-5.
    Cheng, H. Y., Lin, T. C., Yu, K. H., Yang, C. M., & Lin, C. C. (2003). Antioxidant and free radical scavenging activities of Terminalia chebula. Biological & Pharmaceutical Bulletin, 26(9), pp. 1331-5.
    Cheng HY, et al. Antioxidant and Free Radical Scavenging Activities of Terminalia Chebula. Biol Pharm Bull. 2003;26(9):1331-5. PubMed PMID: 12951481.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Antioxidant and free radical scavenging activities of Terminalia chebula. AU - Cheng,Hua-Yew, AU - Lin,Ta-Chen, AU - Yu,Kuo-Hua, AU - Yang,Chien-Min, AU - Lin,Chun-Ching, PY - 2003/9/3/pubmed PY - 2004/4/10/medline PY - 2003/9/3/entrez SP - 1331 EP - 5 JF - Biological & pharmaceutical bulletin JO - Biol. Pharm. Bull. VL - 26 IS - 9 N2 - Free radicals react with biological molecules and destroy the structure of cells, which eventually causes free-radical induced disease such as cancer, renal failure, aging, etc. In this study, 6 extracts and 4 pure compounds of Terminalia chebula RETZ. were investigated for anti-lipid peroxidation, anti-superoxide radical formation and free radical scavenging activities. The superoxide radical scavenging of the 4 pure compounds was further evaluated using electron spin resonance (ESR) spectrometry. The results showed that all tested extracts and pure compounds of T. chebula exhibited antioxidant activity at different magnitudes of potency. The antioxidant activity of each pure compound was derived from different pathways and was suggested to be specific. SN - 0918-6158 UR - https://www.unboundmedicine.com/medline/citation/12951481/Antioxidant_and_free_radical_scavenging_activities_of_Terminalia_chebula_ L2 - http://joi.jlc.jst.go.jp/JST.JSTAGE/bpb/26.1331?from=PubMed DB - PRIME DP - Unbound Medicine ER -