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Effects of megadoses of dietary vitamin E on the antioxidant status of rats fed lard or salmon oil.
Int J Vitam Nutr Res. 2003 Jul; 73(4):275-83.IJ

Abstract

This study was undertaken to investigate whether megadoses of vitamin E in the diet of rats can have pro-oxidative activity. Two experiments with rats were conducted in which both the dietary vitamin E concentration (Experiment 1: 100; 500; 3000; 10,000 mg all-rac-alpha-tocopheryl acetate/kg, and Experiment 2: 100; 1000; 10,000 mg all-rac-alpha-tocopheryl acetate/kg) and the type of dietary fat (lard vs. salmon oil) were varied. Experimental parameters were the concentrations of thiobarbituric acid-reactive substances, 7 beta-hydroxycholesterol, the activities of several antioxidative enzymes, the concentration of glutathione in the liver, and the lag time during copper-induced low-density lipoprotein (LDL) oxidation. Increasing the dietary vitamin E concentration to 10,000 mg all-rac-alpha-tocopheryl acetate/kg led to a significant reduction of thiobarbituric acid-reactive substances in the liver after feeding salmon oil, and also to a significant reduction in 7 beta-hydroxycholesterol after feeding both dietary fats. Megadoses of vitamin E (3000 and 10,000 mg all-rac-alpha-tocopheryl acetate/kg) also led to a reduction in the activity of superoxide dismutase and the concentration of glutathione in the liver of rats fed salmon oil. The lag time during LDL oxidation was independent of the dietary vitamin E concentration. The study shows that megadoses of vitamin E, far from having pro-oxidative activity, actually increase the anti-oxidative capacity of the liver, especially after ingestion of salmon oil.

Authors+Show Affiliations

Institute of Nutritional Sciences, Martin-Luther-University Halle-Wittenberg, Emil-Abderhalden-Strasse 26, 06108 Halle/Saale, Germany.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12951900

Citation

Flader, Diana, et al. "Effects of Megadoses of Dietary Vitamin E On the Antioxidant Status of Rats Fed Lard or Salmon Oil." International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift Fur Vitamin- Und Ernahrungsforschung. Journal International De Vitaminologie Et De Nutrition, vol. 73, no. 4, 2003, pp. 275-83.
Flader D, Brandsch C, Hirche F, et al. Effects of megadoses of dietary vitamin E on the antioxidant status of rats fed lard or salmon oil. Int J Vitam Nutr Res. 2003;73(4):275-83.
Flader, D., Brandsch, C., Hirche, F., & Eder, K. (2003). Effects of megadoses of dietary vitamin E on the antioxidant status of rats fed lard or salmon oil. International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift Fur Vitamin- Und Ernahrungsforschung. Journal International De Vitaminologie Et De Nutrition, 73(4), 275-83.
Flader D, et al. Effects of Megadoses of Dietary Vitamin E On the Antioxidant Status of Rats Fed Lard or Salmon Oil. Int J Vitam Nutr Res. 2003;73(4):275-83. PubMed PMID: 12951900.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of megadoses of dietary vitamin E on the antioxidant status of rats fed lard or salmon oil. AU - Flader,Diana, AU - Brandsch,Corinna, AU - Hirche,Frank, AU - Eder,Klaus, PY - 2003/9/4/pubmed PY - 2004/2/5/medline PY - 2003/9/4/entrez SP - 275 EP - 83 JF - International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition JO - Int J Vitam Nutr Res VL - 73 IS - 4 N2 - This study was undertaken to investigate whether megadoses of vitamin E in the diet of rats can have pro-oxidative activity. Two experiments with rats were conducted in which both the dietary vitamin E concentration (Experiment 1: 100; 500; 3000; 10,000 mg all-rac-alpha-tocopheryl acetate/kg, and Experiment 2: 100; 1000; 10,000 mg all-rac-alpha-tocopheryl acetate/kg) and the type of dietary fat (lard vs. salmon oil) were varied. Experimental parameters were the concentrations of thiobarbituric acid-reactive substances, 7 beta-hydroxycholesterol, the activities of several antioxidative enzymes, the concentration of glutathione in the liver, and the lag time during copper-induced low-density lipoprotein (LDL) oxidation. Increasing the dietary vitamin E concentration to 10,000 mg all-rac-alpha-tocopheryl acetate/kg led to a significant reduction of thiobarbituric acid-reactive substances in the liver after feeding salmon oil, and also to a significant reduction in 7 beta-hydroxycholesterol after feeding both dietary fats. Megadoses of vitamin E (3000 and 10,000 mg all-rac-alpha-tocopheryl acetate/kg) also led to a reduction in the activity of superoxide dismutase and the concentration of glutathione in the liver of rats fed salmon oil. The lag time during LDL oxidation was independent of the dietary vitamin E concentration. The study shows that megadoses of vitamin E, far from having pro-oxidative activity, actually increase the anti-oxidative capacity of the liver, especially after ingestion of salmon oil. SN - 0300-9831 UR - https://www.unboundmedicine.com/medline/citation/12951900/Effects_of_megadoses_of_dietary_vitamin_E_on_the_antioxidant_status_of_rats_fed_lard_or_salmon_oil_ L2 - https://econtent.hogrefe.com/doi/10.1024/0300-9831.73.4.275?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -